Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen

Derivation of neural precursor cells from human ES cells at 3% O2 is efficient, enhances survival and presents no barrier to regional specification and functional differentiation

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Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

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Neural stem cell systems: physiological players or in vitro entities?

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Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair

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PO2 Matters in Stem Cell Culture

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Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

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Neuronal cell replacement in Parkinson’s disease

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Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

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Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

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Voltage-clamp and current-clamp recordings from mammalian DRG neurons

(2009) Theodore R Cummins et al.   Nature Protocols

Differentiation of spinal motor neurons from pluripotent human stem cells

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Hypoxia Alters Cell Cycle Regulatory Protein Expression and Induces Premature Maturation of Oligodendrocyte Precursor Cells

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Activin/Nodal Inhibition Alone Accelerates Highly Efficient Neural Conversion from Human Embryonic Stem Cells and Imposes a Caudal Positional Identity

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Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

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Low Oxygen Enhances Primitive and Definitive Neural Stem Cell Colony Formation by Inhibiting Distinct Cell Death Pathways

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Nicotinamide Rescues Human Embryonic Stem Cell-Derived Neuroectoderm from Parthanatic Cell Death

(2009) Flavio Cimadamore et al.   STEM CELLS

Combined use of BDNF, ascorbic acid, low oxygen, and prolonged differentiation time generates tyrosine hydroxylase-expressing neurons after long-term in vitro expansion of human fetal midbrain precursor cells

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Hypoxia-driven proliferation of embryonic neural stem/progenitor cells - role of hypoxia-inducible transcription factor-1α

(2008) Tong Zhao et al.   FEBS Journal

Efficient derivation of functional dopaminergic neurons from human embryonic stem cells on a large scale

(2008) Myung-Soo Cho et al.   Nature Protocols

The role of oxygen availability in embryonic development and stem cell function

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Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells

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Directed Differentiation of Ventral Spinal Progenitors and Motor Neurons from Human Embryonic Stem Cells by Small Molecules

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Human Embryonic Stem Cell Differentiation Toward Regional Specific Neural Precursors

(2008) Slaven Erceg et al.   STEM CELLS