Redesigning the DNA-Targeted Chromophore in Platinum-Acridine Anticancer Agents: A Structure-Activity Relationship Study

Monofunctional Platinum(II) Complexes with Potent Tumor Cell Growth Inhibitory Activity: The Effect of a Hydrogen-Bond Donor/Acceptor N-Heterocyclic Ligand

(2014) Nicola Margiotta et al.   ChemMedChem

Using Fluorescent Post-Labeling To Probe the Subcellular Localization of DNA-Targeted Platinum Anticancer Agents

(2013) Song Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ellipticine Binds to a Human Telomere Sequence: An Additional Mode of Action as a Putative Anticancer Agent?

(2013) Saptaparni Ghosh et al.   BIOCHEMISTRY

The Cell’s Nucleolus: an Emerging Target for Chemotherapeutic Intervention

(2013) Amanda J. Pickard et al.   ChemMedChem

Deprotonation Mechanism and Acidity Constants in Aqueous Solution of Flavonols: a Combined Experimental and Theoretical Study

(2013) Ruslán Álvarez-Diduk et al.   JOURNAL OF PHYSICAL CHEMISTRY B

PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outs

(2013) Ken A. Olaussen et al.   LUNG CANCER

Comparative Chemogenomics To Examine the Mechanism of Action of DNA-Targeted Platinum-Acridine Anticancer Agents

(2012) Kahlin Cheung-Ong et al.   ACS Chemical Biology

DNA Metalating-Intercalating Hybrid Agents for the Treatment of Chemoresistant Cancers

(2012) Jimmy Suryadi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, Aqueous Reactivity, and Biological Evaluation of Carboxylic Acid Ester-Functionalized Platinum–Acridine Hybrid Anticancer Agents

(2012) Leigh A. Graham et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using a Build-and-Click Approach for Producing Structural and Functional Diversity in DNA-Targeted Hybrid Anticancer Agents

(2012) Song Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the DNA damage produced by a platinum–acridine antitumor agent and its effects in NCI-H460 lung cancer cells

(2012) Xin Qiao et al.   Metallomics

Subcellular targets of cisplatin cytotoxicity: An integrated view

(2012) Sandra M. Sancho-Martínez et al.   PHARMACOLOGY & THERAPEUTICS

Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile

(2012) Ga Young Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Pt Adducts Following Cisplatin Treatment of Saccharomyces cerevisiae

(2011) Alethia A. Hostetter et al.   ACS Chemical Biology

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Replacement of a Thiourea with an Amidine Group in a Monofunctional Platinum–Acridine Antitumor Agent. Effect on DNA Interactions, DNA Adduct Recognition and Repair

(2011) Hana Kostrhunova et al.   MOLECULAR PHARMACEUTICS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Prodrugs--from Serendipity to Rational Design

(2011) K. M. Huttunen et al.   PHARMACOLOGICAL REVIEWS

Inhibition of DNA Synthesis by a Platinum–Acridine Hybrid Agent Leads to Potent Cell Kill in Nonsmall Cell Lung Cancer

(2011) Christopher L. Smyre et al.   ACS Medicinal Chemistry Letters

Resistance to platinum-based chemotherapy in lung cancer cell lines

(2010) Jianli Chen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer

(2010) David J. Stewart   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Energetics and Kinetics of a Conformational Switch in G-Quadruplex DNA†

(2009) Robert D. Gray et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Targeted therapies for non-small cell lung cancer

(2009) Wolfram C.M. Dempke et al.   LUNG CANCER

Shortcomings of current therapies for non-small-cell lung cancer: unmet medical needs

(2009) H A Burris   ONCOGENE

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Non-Cross-Linking Platinum−Acridine Agent with Potent Activity in Non-Small-Cell Lung Cancer

(2008) Zhidong Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhancement of Cisplatin [cis-Diammine Dichloroplatinum (II)] Cytotoxicity by O6-Benzylguanine Involves Endoplasmic Reticulum Stress

(2008) C. A. Rabik et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer

(2007) Tetsuya Fujii et al.   LUNG CANCER