Ruthenium-Arene-β-Carboline Complexes as Potent Inhibitors of Cyclin-Dependent Kinase 1: Synthesis, Characterization and Anticancer Mechanism Studies

Am(m)ines Make the Difference: Organoruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development

(2013) Maria V. Babak et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes

(2012) Sebastian Blanck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Designing organometallic compounds for catalysis and therapy

(2012) Anna Louisa Noffke et al.   CHEMICAL COMMUNICATIONS

Anticancer Activity of Hydrogen-Bond-Stabilized Half-Sandwich RuIIComplexes with Heterocycles

(2012) Raja Mitra et al.   CHEMISTRY-A EUROPEAN JOURNAL

Preparation of Organometallic Ruthenium-Arene-Diaminotriazine Complexes as Binding Agents to DNA

(2012) Natalia Busto et al.   Chemistry-An Asian Journal

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

(2012) Anaïs Pitto-Barry et al.   INORGANIC CHEMISTRY

Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity

(2012) Soledad Betanzos-Lara et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Preparation of new half sandwich ruthenium arene complexes with aminophosphines as potential chemotherapeutics

(2012) Cristina Aliende et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines

(2012) Werner Ginzinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Quest for Target Specificity

(2011) Eric Meggers   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents

(2011) Vaishali Vajpayee et al.   CHEMICAL COMMUNICATIONS

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

(2011) Muhammad Hanif et al.   CHEMICAL COMMUNICATIONS

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

(2011) Bin Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Anticancer Metallotherapeutics in Preclinical Development

(2011) G. N. Kaluderovic et al.   CURRENT MEDICINAL CHEMISTRY

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Studies on characterization, telomerase inhibitory properties and G-quadruplex binding of η6-arene ruthenium complexes with 1,10-phenanthroline-derived ligands

(2011) Dongdong Sun et al.   DALTON TRANSACTIONS

Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells

(2011) Iryna N. Stepanenko et al.   INORGANIC CHEMISTRY

A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis

(2011) Soumya Chatterjee et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Approaching tumour therapy beyond platinum drugs

(2011) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ruthenium–Arene Complexes of Curcumin: X-Ray and Density Functional Theory Structure, Synthesis, and Spectroscopic Characterization, in Vitro Antitumor Activity, and DNA Docking Studies of (p-Cymene)Ru(curcuminato)chloro

(2011) Francesco Caruso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

(2011) Li Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differences in the Cellular Response and Signaling Pathways between Cisplatin and Monodentate Organometallic Ru(II) Antitumor Complexes Containing a Terphenyl Ligand

(2011) Anna Kisova et al.   MOLECULAR PHARMACEUTICS

Ruthenium-based chemotherapeutics: are they ready for prime time?

(2010) Emmanuel S. Antonarakis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

(2010) Caiping Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of an Organometallic Glutathione Transferase Inhibitor

(2009) Wee Han Ang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs

(2009) Sabine H. van Rijt et al.   DRUG DISCOVERY TODAY

Ruthenium(II) Arene Anticancer Complexes with Redox-Active Diamine Ligands

(2009) Tijana Bugarcic et al.   INORGANIC CHEMISTRY

Exploring metallodrug–protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound

(2009) Angela Casini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity

(2009) Maria G. Mendoza-Ferri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in ruthenium anticancer drugs

(2009) Aviva Levina et al.   Metallomics

Platinum neurotoxicity pharmacogenetics

(2009) S. R. McWhinney et al.   MOLECULAR CANCER THERAPEUTICS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Design, synthesis and biological evaluation of new tryptamine and tetrahydro-β-carboline-based selective inhibitors of CDK4

(2008) Paul R. Jenkins et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Contrasting Chemistry and Cancer Cell Cytotoxicity of Bipyridine and Bipyridinediol Ruthenium(II) Arene Complexes

(2008) Tijana Bugarcic et al.   INORGANIC CHEMISTRY

The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways

(2008) Soumya Chatterjee et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

(2008) Angela Casini et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA Structural Distortions Induced by Ruthenium−Arene Anticancer Compounds

(2008) Christian Gossens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY