Article
Biochemistry & Molecular Biology
Miroslava Kacaniova, Nenad L. Vukovic, Natalia Cmikova, Lucia Galovicova, Marianna Schwarzova, Veronika Simora, Przemyslaw Lukasz Kowalczewski, Maciej Ireneusz Kluz, Czeslaw Puchalski, Ladislav Bakay, Milena D. Vukic
Summary: This study analyzed the chemical composition and various properties of Salvia sclarea essential oil (SSEO). The results showed that SSEO has moderate antimicrobial and antibiofilm activities, as well as insecticidal potential. The study also identified the main constituents of SSEO and their antioxidant activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Fatouma Mohamed Abdoul-Latif, Abdirahman Elmi, Ali Merito, Moustapha Nour, Arnaud Risler, Ayoub Ainane, Jerome Bignon, Tarik Ainane
Summary: In this study, the anticancer activities of the tropical medicinal plant Ruta chalepensis L. from Djibouti were investigated, revealing its effectiveness against various cancer cell lines. The main volatile compound identified was 2-undecanone (51.3%), and correlation modeling confirmed the potential of the essential oil as a natural source of anticancer agents. These findings offer promising prospects for targeted investigations and good biomass management in the future.
Article
Biochemistry & Molecular Biology
Agnieszka Szewczyk, Andreana Marino, Jessica Molinari, Halina Ekiert, Natalizia Miceli
Summary: In this study, in vitro cultures of three species of the genus Ruta were examined. The growth dynamics and secondary metabolite accumulation were analyzed, and the antioxidant capacity and antimicrobial potential were evaluated. The results showed variations in antioxidant capacity and antimicrobial activity among the tested species.
Article
Plant Sciences
Natalia Cmikova, Lucia Galovicova, Marianna Schwarzova, Milena D. Vukic, Nenad L. Vukovic, Przemyslaw Lukasz Kowalczewski, Ladislav Bakay, Maciej Ireneusz Kluz, Czeslaw Puchalski, Miroslava Kacaniova
Summary: This study analyzed the chemical composition and various biological activities of Eucalyptus globulus essential oil (EGEO). The main components of EGEO were identified as 1,8-cineole, p-cimene, α-pinene, and α-limonene. The results showed that EGEO exhibited significant antimicrobial, antibiofilm, antioxidant, and insecticidal activities.
Article
Plant Sciences
Khaoula Diass, Mohammed Merzouki, Kaoutar Elfazazi, Hanane Azzouzi, Allal Challioui, Khalil Azzaoui, Belkheir Hammouti, Rachid Touzani, Flore Depeint, Alicia Ayerdi Gotor, Larbi Rhazi
Summary: The purpose of this study was to determine the chemical composition of Lavandula officinalis essential oil and evaluate its antibacterial effects against seven pathogenic bacteria strains. The results showed that E. coli and S.newport were sensitive to the essential oil, and four strains were remarkably sensitive with MIC values of 88.7 μg/mL and 177.5 μg/mL. Molecular docking analysis indicated that eucalyptol and linalyl acetate efficiently bind with the active site of the target protein, showing higher activity than the positive control gentamicin.
Article
Multidisciplinary Sciences
Sarunpron Khruengsai, Teerapong Sripahco, Narawadee Rujanapun, Rawiwan Charoensup, Patcharee Pripdeevech
Summary: Essential oil extracted from Peucedanum dhana A. Ham in Thailand contained compounds such as trans-piperitol and beta-pinene. The oil exhibited significant antimicrobial activity against pathogens, and demonstrated antibacterial action against Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes. Additionally, the oil showed antioxidant activity and cytotoxicity against cancer cells, suggesting its potential application in food and pharmaceutical industries.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Iliya Zhelev, Zhana Petkova, Iliana Kostova, Stanka Damyanova, Albena Stoyanova, Ivanka Dimitrova-Dyulgerova, Ginka Antova, Sezai Ercisli, Amine Assouguem, Mohammed Kara, Rafa Almeer, Amany A. Sayed
Summary: The chemical composition of Vitex agnus castus L. fruits from two regions in Bulgaria was investigated, revealing significant differences in proteins, carbohydrates, and essential oil content between the regions.
Article
Chemistry, Applied
Natale Badalamenti, Antonella Porrello, Robina Maihan, Maurizio Bruno
Summary: Plectranthus L 'Her is a large genus of Lamiaceae family that includes about 300 species distributed in the tropical and warm regions of the Old-World. Some species are edible and used for traditional medicinal purposes in several countries. Phytochemical investigations have revealed that species in this genus contain diterpenoids with abietane, phyllocladanes, and kaurene skeleton. This study analyzed the essential oil composition of Plectranthus ornatus, an invasive and ornamental plant with traditional medicinal uses, for the first time in Israel, using gas chromatography-mass spectrometry (GC-MS). Comparisons were made with other essential oils from P. ornatus accessions.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lutfun Nahar, Hesham R. El-Seedi, Shaden A. M. Khalifa, Majid Mohammadhosseini, Satyajit D. Sarker
Summary: Ruta L. is a typical genus of the citrus family, mainly distributed in the Mediterranean region, and has long been used in traditional medicines for various purposes. Ruta species are rich in essential oils, predominantly aliphatic ketones, and have been studied for their bioactivities and potential applications in medicine and agriculture. This review critically evaluates the composition and bioactivities of essential oils from Ruta species and discusses potential applications of nanotechnology and chitosan-based products.
Article
Agronomy
Renata Nurzynska-Wierdak, Andrzej Salata, Magdalena Kniaziewicz
Summary: This research evaluated the morphological and chemical properties of tansy plants growing in various natural habitats, including the content and composition of essential oil, flavonoids, phenolic acids, and antioxidant activity levels. The variability in the chemical composition of tansy was found to be influenced by environmental and genetic factors.
Article
Food Science & Technology
Meiping Li, Xiying Zhao, Manjun Xu
Summary: This study investigates the chemical composition, antimicrobial, and antioxidant activities of essential oil from Allium tenuissimum L. flowers. The essential oil contains 72 volatile components, with terpenoid compounds and sulfurous compounds, especially dimethyl trisulfide, being the most abundant. The oil demonstrates significant antimicrobial efficiency against various pathogens and exhibits high stability to UV. Additionally, the essential oil shows strong radical-scavenging effects, making it a potential natural antibacterial and antioxidant agent in the food industry.
Article
Biochemistry & Molecular Biology
Tao Chen, Qingbo Kong, Xuekun Kuang, Jiasi Zhou, Haizhou Wang, Lijun Zhou, Hongyu Yang, Shiling Feng, Chunbang Ding
Summary: This study extracted essential oils from Litsea pungens and evaluated their chemical components and pharmacological activities. The essential oils showed antioxidant and antibacterial properties, with the fresh fruit essential oil exhibiting the strongest antibacterial effect. These findings suggest that Litsea pungens could be a promising medicinal and edible plant candidate.
Article
Chemistry, Multidisciplinary
Onur Demirkol, Mehmet Ersatir, Elife Sultan Giray, Saliha Kirici
Summary: This study investigated the extraction of compounds from Ruta chalepensis roots using different extraction methods. The results showed that subcritical water extraction at 125℃ and 60 atm was the most efficient, and furanocoumarins were the most abundant components in the extracts.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Biochemistry & Molecular Biology
Le Thi Huong, Nguyen Huy Hung, Nguyen Ngoc Linh, Ty Viet Pham, Do Ngoc Dai, Nguyen Quang Hop, William N. Setzer, Ninh The Son, Wilfried Andlauer, Wolfram Manuel Bruck
Summary: The essential oils of five Vietnamese Syzygium species showed good antimicrobial activities and potential for use as green alternatives for the control of mosquitoes.
Article
Plant Sciences
Jamila El Karkouri, Mohamed Bouhrim, Omkulthom Mohamed Al Kamaly, Hamza Mechchate, Amal Kchibale, Imad Adadi, Sanae Amine, Souad Alaoui Ismaili, Touriya Zair
Summary: Cistus ladanifer L. is a plant widely used in folk medicine that demonstrates powerful antibacterial and moderate antifungal properties in its essential oil. The major components of the essential oil are viridiflorol, pinocarveol, bornylacetate, and ledol.
Article
Chemistry, Applied
Xilong Liu, Haibo Wu, Xiaojun Tao, Xixiang Ying, Didier Stien
Summary: Two novel amide glycosides, oleraciamide E and oleraciamide F, were isolated from Portulaca oleracea L. Oleraciamide E exhibited anticholinesterase and scavenging activities.
NATURAL PRODUCT RESEARCH
(2021)
Editorial Material
Chemistry, Medicinal
Didier Stien
Article
Plant Sciences
Laure-Anne Peyrat, Veronique Eparvier, Cecilia Eydoux, Jean-Claude Guillemot, Marc Litaudon, Didier Stien
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Biochemistry & Molecular Biology
Jonathan Sorres, Amandine Andre, Elsa Van Elslande, Didier Stien, Veronique Eparvier
Article
Chemistry, Medicinal
C. A. Downs, Joseph C. DiNardo, Didier Stien, Alice M. S. Rodrigues, Philippe Lebaron
Summary: The study investigated the presence of benzophenone in commercial sunscreen products, the increase in benzophenone concentration over time, and the source of benzophenone contamination from octocrylene degradation. The results showed that octocrylene can generate benzophenone through a reaction, and up to 70% of benzophenone in sunscreen products may be absorbed through the skin. Regulatory agencies should promptly review the safety of octocrylene as a benzophenone generator in SPF or any consumer products.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Letter
Chemistry, Medicinal
C. A. Downs, Joseph DiNardo, Didier Stien, Alice M. S. Rodrigues, Philippe Lebaron
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Morgane Barthelemy, Nicolas Elie, Gregory Genta-Jouve, Didier Stien, David Touboul, Veronique Eparvier
Summary: This study isolated endophytes from palm trees in French Guiana and discovered new compounds with antifungal properties against Fusarium oxysporum. The investigation also identified a previously unknown compound named focicin produced by the phytopathogen during competition. Chemical interactions between the endophytic strain and the phytopathogen were highlighted using MALDI-TOF MS imaging.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Microbiology
Leonie Pellissier, Sara Leoni, Laurence Marcourt, Emerson Ferreira Queiroz, Nicole Lecoultre, Luis-Manuel Quiros-Guerrero, Morgane Barthelemy, Veronique Eparvier, Jerome Chave, Didier Stien, Katia Gindro, Karl Perron, Jean-Luc Wolfender
Summary: Pseudomonas aeruginosa, a critical priority pathogen with multidrug resistance, uses quorum sensing to collectively produce virulence factors. Fungal endophytes represent an under-explored source of novel quorum sensing inhibitors (QSI), with potential for discovering new antimicrobial agents. Lasiodiplodia venezuelensis, an endophytic strain, was found to have selective activity as a QSI against P. aeruginosa, leading to the isolation of compounds with anti-QS effects.
Article
Biochemical Research Methods
Alice M. S. Rodrigues, Raphael Lami, Karine Escoubeyrou, Laurent Intertaglia, Clement Mazurek, Margot Doberva, Pedro Perez-Ferrer, Didier Stien
Summary: This study presents a simple and accessible method to detect, annotate, and quantify AHLs in bacterial culture media. The method utilizes an ultra-high-performance liquid chromatography system coupled with a mass spectrometer using a nontargeted FullMS data-dependent MS2 method. Results were processed using MZmine2 and analyzed by the Feature-Based Molecular Networking (FBMN) workflow in the Global Natural Products Social Networking (GNPS) platform. The study demonstrates the automatic annotation of known AHLs and the ability to search for unknown AHLs, even without analytical standards. The method also provides relative quantification information.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Layal Fahed, Marc El Beyrouthy, Naim Ouaini, Veronique Eparvier, Didier Stien, Sara Vitalini, Marcello Iriti
Summary: Lebanese Hypericum scabrum essential oil showed strong antifungal activity against filamentous fungi, potentially due to minor constituents. A synergistic effect was observed when combined with the antifungal drug amphotericin B.
Article
Biochemistry & Molecular Biology
Jonathan Sorres, Teo Hebra, Nicolas Elie, Charlotte Leman-Loubiere, Tatyana Grayfer, Philippe Grellier, David Touboul, Didier Stien, Veronique Eparvier
Summary: This study discovered antiprotozoal activities of ovalicin derivatives produced by a fungus isolated from termites and revealed the related compounds and genes through metabolomic and genomic analyses.
Article
Chemistry, Medicinal
Evane Thorel, Fanny Clergeaud, Alice M. S. Rodrigues, Philippe Lebaron, Didier Stien
Summary: This study investigates the effects of octocrylene on two coral species and reveals that it can cause mitochondrial dysfunction and cellular senescence. The impact on a second coral species suggests that environmental octocrylene pollution may affect various reef-building species. Additionally, the research demonstrates that octocrylene can be modified by organisms and its contamination levels in the food chain may have been underestimated.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Chemistry, Analytical
Aude Gandar, Thierry Noguer, Vitalys Mba Ekomo, Alice M. S. Rodrigues, Didier Stien, Carole Calas-Blanchard
Summary: This study quantified four UV filters used in cosmetics by spectroelectochemistry. Electrochemical activity of the filters resulted in modification of their absorption spectrum. Combining spectral deconvolution of spectra pairs was more accurate in identifying and quantifying UV filters than deconvolution of initial absorbance spectrum alone.
Article
Biochemistry & Molecular Biology
Fanny Clergeaud, Maeva Giraudo, Alice M. S. Rodrigues, Evane Thorel, Philippe Lebaron, Didier Stien
Summary: The extensive use of sunscreen products has caused concerns about their environmental toxicity and the negative effects they have on ecologically important coral communities. Metabolomic analyses on Pocillopora damicornis exposed to the UV filter avobenzone (BM) revealed unidentified ions in the coral's metabolome. Further analysis found that BM-exposed corals had 57 ions with significantly different relative concentrations, including 17 BM derivatives and one major derivative, C16:0-dihydroBM. These findings suggest that BM exposure may impair the photosynthetic capacity of coral holobionts and that the impact of BM derivatives should be considered in future environmental assessments.
Article
Marine & Freshwater Biology
Julie Lucas, Valentin Logeux, Alice M. S. Rodrigues, Didier Stien, Philippe Lebaron
Summary: Chemical UV filters released into the aquatic environment can affect the development of fish eggs. This study evaluated the toxicity of six commonly used UV filters on the embryo-larval stages of zebrafish and found that octocrylene delayed hatching success while 2-ethylhexyl salicylate increased heartbeat rate.
OCEANS-SWITZERLAND
(2022)
