Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

Amyloid Aggregation Inhibitory Mechanism of Arginine-rich D-peptides

(2014) O.O. Olubiyi et al.   CURRENT MEDICINAL CHEMISTRY

Comparative Molecular Dynamics Study of Human Islet Amyloid Polypeptide (IAPP) and Rat IAPP Oligomers

(2013) Guizhao Liang et al.   BIOCHEMISTRY

Aggregation of Alzheimer’s Amyloid β-Peptide in Biological Membranes: A Molecular Dynamics Study

(2013) Justin A. Lemkul et al.   BIOCHEMISTRY

Stabilities and structures of islet amyloid polypeptide (IAPP22–28) oligomers: From dimer to 16-mer

(2013) Jingjing Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Conformational Distribution and α-Helix to β-Sheet Transition of Human Amylin Fragment Dimer

(2013) Ruxi Qi et al.   BIOMACROMOLECULES

A micro-environmental study of the Zn+2–Aβ1–16 structural properties

(2013) A. Maiorana et al.   BIOPHYSICAL CHEMISTRY

Mechanism of Membrane Permeation Induced by Synthetic β-Hairpin Peptides

(2013) Kshitij Gupta et al.   BIOPHYSICAL JOURNAL

Differences in β-strand Populations of Monomeric Aβ40 and Aβ42

(2013) K. Aurelia Ball et al.   BIOPHYSICAL JOURNAL

Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP

(2013) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Effect of Proline Mutations on the Monomer Conformations of Amylin

(2013) Chi-cheng Chiu et al.   BIOPHYSICAL JOURNAL

Membrane Permeation Induced by Aggregates of Human Islet Amyloid Polypeptides

(2013) Chetan Poojari et al.   BIOPHYSICAL JOURNAL

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Molecular insights into the reversible formation of tau protein fibrils

(2013) Yin Luo et al.   CHEMICAL COMMUNICATIONS

Insights into Aβ Aggregation: A Molecular Dynamics Perspective

(2013) Joan-Emma Shea et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Characterization of the polymorphic states of copper(II)-bound Aβ(1-16) peptides by computational simulations

(2013) Liang Xu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Discrete Molecular Dynamics Study of Oligomer Formation by N-Terminally Truncated Amyloid β-Protein

(2013) Derya Meral et al.   JOURNAL OF MOLECULAR BIOLOGY

Aβ Monomers Transiently Sample Oligomer and Fibril-Like Configurations: Ensemble Characterization Using a Combined MD/NMR Approach

(2013) David J. Rosenman et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of cholesterol-assisted oligomeric channel formation by a short Alzheimer β-amyloid peptide

(2013) Coralie Di Scala et al.   JOURNAL OF NEUROCHEMISTRY

Familial Alzheimer’s Disease Osaka Mutant (ΔE22) β-Barrels Suggest an Explanation for the Different Aβ1–40/42 Preferred Conformational States Observed by Experiment

(2013) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Simulations Indicate Marked Differences in the Structure of Amylin Mutants, Correlated with Known Aggregation Propensity

(2013) Cayla Miller et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Mechanism of the Inhibition of EGCG on the Alzheimer Aβ1–42 Dimer

(2013) Tong Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Identification of a Common Binding Mode for Imaging Agents to Amyloid Fibrils from Molecular Dynamics Simulations

(2013) Katrine Kirkeby Skeby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers

(2013) Xiang Yu et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Alzheimer's disease: which type of amyloid-preventing drug agents to employ?

(2013) Hyunbum Jang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20–29) fragments

(2013) Jeffrey R. Brender et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient  -sheet

(2013) L. E. Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wild type and mutants of the HET-s(218-289) prion show different flexibility at fibrillar ends: A simulation study

(2013) Ran Friedman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular dynamics simulations of mechanical failure in polymorphic arrangements of amyloid fibrils containing structural defects

(2013) Hlengisizwe Ndlovu et al.   Beilstein Journal of Nanotechnology

Mechanism of amyloid β−protein dimerization determined using single−molecule AFM force spectroscopy

(2013) Zhengjian Lv et al.   Scientific Reports

Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides

(2013) Chun Wu et al.   PLoS Computational Biology

Probing Structural Features of Alzheimer’s Amyloid-β Pores in Bilayers Using Site-Specific Amino Acid Substitutions

(2012) Ricardo Capone et al.   BIOCHEMISTRY

Effects of Point Substitutions on the Structure of Toxic Alzheimer’s β-Amyloid Channels: Atomic Force Microscopy and Molecular Dynamics Simulations

(2012) Laura Connelly et al.   BIOCHEMISTRY

Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation

(2012) Michele F. M. Sciacca et al.   BIOCHEMISTRY

Probing ion channel activity of human islet amyloid polypeptide (amylin)

(2012) Jun Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

How the amyloid-β peptide and membranes affect each other: An extensive simulation study

(2012) Chetan Poojari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of Sequence Variation on the Mechanical Response of Amyloid Fibrils Probed by Steered Molecular Dynamics Simulation

(2012) Hlengisizwe Ndlovu et al.   BIOPHYSICAL JOURNAL

Unlocking the Atomic-Level Details of Amyloid Fibril Growth through Advanced Biomolecular Simulations

(2012) Nicolae-Viorel Buchete   BIOPHYSICAL JOURNAL

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Investigating How Peptide Length and a Pathogenic Mutation Modify the Structural Ensemble of Amyloid Beta Monomer

(2012) Yu-Shan Lin et al.   BIOPHYSICAL JOURNAL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Metal binding sites in amyloid oligomers: Complexes and mechanisms

(2012) Yifat Miller et al.   COORDINATION CHEMISTRY REVIEWS

Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

(2012) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid peptide Aβ40 inhibits aggregation of Aβ42: Evidence from molecular dynamics simulations

(2012) Man Hoang Viet et al.   JOURNAL OF CHEMICAL PHYSICS

All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

(2012) Ricardo Capone et al.   Journal of Chemical Theory and Computation

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

(2012) Hyunbum Jang et al.   Journal of Chemical Theory and Computation

Distinct Dimerization for Various Alloforms of the Amyloid-Beta Protein: Aβ1–40, Aβ1–42, and Aβ1–40(D23N)

(2012) Sébastien Côté et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-d-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology

(2012) Laura Connelly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformational Basis for Asymmetric Seeding Barrier in Filaments of Three- and Four-Repeat Tau

(2012) Ayisha Siddiqua et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study

(2012) Bogdan Barz et al.   PLoS One

Alzheimer Aβ peptide interactions with lipid membranes

(2012) Florentina Tofoleanu et al.   Prion

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

(2012) L. Milanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Water in Protein Aggregation and Amyloid Polymorphism

(2011) D. Thirumalai et al.   ACCOUNTS OF CHEMICAL RESEARCH

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aβ(39–42) Modulates Aβ Oligomerization but Not Fibril Formation

(2011) Megan Murray Gessel et al.   BIOCHEMISTRY

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Membrane and surface interactions of Alzheimer’s Aβ peptide - insights into the mechanism of cytotoxicity

(2011) Thomas L. Williams et al.   FEBS Journal

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses

(2011) Satoko Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-channel Ca2+imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

(2011) Angelo Demuro et al.   JOURNAL OF CELL BIOLOGY

Amyloid-β peptide structure in aqueous solution varies with fragment size

(2011) Olivia Wise-Scira et al.   JOURNAL OF CHEMICAL PHYSICS

Selective Molecular Recognition in Amyloid Growth and Transmission and Cross-Species Barriers

(2011) Buyong Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

The Unique Alzheimer’s β-Amyloid Triangular Fibril Has a Cavity along the Fibril Axis under Physiological Conditions

(2011) Yifat Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular-Level Examination of Cu2+Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

(2011) Sudhakar Parthasarathy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Structural Model of Aβ40Fibrils

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation

(2011) Fernando Terán Arce et al.   Soft Matter

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutations Alter the Geometry and Mechanical Properties of Alzheimer’s Aβ(1−40) Amyloid Fibrils

(2010) Raffaella Paparcone et al.   BIOCHEMISTRY

Simultaneous Single-Molecule Fluorescence and Conductivity Studies Reveal Distinct Classes of Aβ Species on Lipid Bilayers

(2010) Joseph A. Schauerte et al.   BIOCHEMISTRY

Lipids and Alzheimer's disease

(2010) Brett Garner   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Antimicrobial Protegrin-1 Forms Ion Channels: Molecular Dynamic Simulation, Atomic Force Microscopy, and Electrical Conductance Studies

(2010) Ricardo Capone et al.   BIOPHYSICAL JOURNAL

Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

(2010) Yifat Miller et al.   CHEMICAL REVIEWS

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hollow core of Alzheimer's A 42 amyloid observed by cryoEM is relevant at physiological pH

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc ions promote Alzheimer A  aggregation via population shift of polymorphic states

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels

(2009) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation

(2009) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational Insights into Aspartyl Protease Activity of Presenilin 1 (PS1) Generating Alzheimer Amyloid β-Peptides (Aβ40 and Aβ42)

(2009) Rajiv Singh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of the Amyloid-β (1−42) Monomer Absorbed To Model Phospholipid Bilayers: A Molecular Dynamics Study

(2009) Charles H. Davis et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Influence of Preformed Asp23−Lys28 Salt Bridge on the Conformational Fluctuations of Monomers and Dimers of Aβ Peptides with Implications for Rates of Fibril Formation

(2009) Govardhan Reddy et al.   JOURNAL OF PHYSICAL CHEMISTRY B

K3 Fragment of Amyloidogenic β2-Microglobulin Forms Ion Channels: Implication for Dialysis Related Amyloidosis

(2009) Mirela Mustata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity

(2009) Giuseppe D. Ciccotosto et al.   NEUROBIOLOGY OF AGING

Interprotofilament interactions between Alzheimer's A 1-42 peptides in amyloid fibrils revealed by cryoEM

(2009) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†

(2008) Jeffrey R. Brender et al.   BIOCHEMISTRY

Models of Toxic β-Sheet Channels of Protegrin-1 Suggest a Common Subunit Organization Motif Shared with Toxic Alzheimer β-Amyloid Ion Channels

(2008) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

The two-fold aspect of the interplay of amyloidogenic proteins with lipid membranes

(2008) Annalisa Relini et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Familial Alzheimer’s Disease Mutations on the Folding Nucleation of the Amyloid β-Protein

(2008) Mary Griffin Krone et al.   JOURNAL OF MOLECULAR BIOLOGY

Aβ(1-40) Fibril Polymorphism Implies Diverse Interaction Patterns in Amyloid Fibrils

(2008) Jessica Meinhardt et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Dynamics of the Aβ21–30Peptide from the Interplay of NMR Experiments and Molecular Simulations

(2008) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

(2008) Dror Noy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-β peptide

(2008) Eva Y. Chi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

New structures help the modeling of toxic amyloidß ion channels

(2008) Hyunbum Jang et al.   TRENDS IN BIOCHEMICAL SCIENCES

NMR Studies of the Zn2+Interactions with Rat and Human β-Amyloid (1−28) Peptides in Water-Micelle Environment

(2007) Elena Gaggelli et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING

On the nucleation of amyloid β-protein monomer folding

(2005) Noel D. Lazo et al.   PROTEIN SCIENCE

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY