Alzheimer's disease: which type of amyloid-preventing drug agents to employ?

Neuron Specific Toxicity of Oligomeric Amyloid-β: Role for JUN-Kinase and Oxidative Stress

(2017) Philip J. Ebenezer et al.   JOURNAL OF ALZHEIMERS DISEASE

The KATP Channel Activator Diazoxide Ameliorates Amyloid-β and Tau Pathologies and Improves Memory in the 3xTgAD Mouse Model of Alzheimer's Disease

(2017) Dong Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Is the Amyloid Hypothesis of Alzheimer's disease therapeutically relevant?

(2012) Andrew F. Teich et al.   BIOCHEMICAL JOURNAL

Probing Structural Features of Alzheimer’s Amyloid-β Pores in Bilayers Using Site-Specific Amino Acid Substitutions

(2012) Ricardo Capone et al.   BIOCHEMISTRY

Effects of Point Substitutions on the Structure of Toxic Alzheimer’s β-Amyloid Channels: Atomic Force Microscopy and Molecular Dynamics Simulations

(2012) Laura Connelly et al.   BIOCHEMISTRY

Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation

(2012) Michele F. M. Sciacca et al.   BIOCHEMISTRY

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Metal binding sites in amyloid oligomers: Complexes and mechanisms

(2012) Yifat Miller et al.   COORDINATION CHEMISTRY REVIEWS

Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

(2012) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

(2012) Ricardo Capone et al.   Journal of Chemical Theory and Computation

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

(2012) Hyunbum Jang et al.   Journal of Chemical Theory and Computation

Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-d-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology

(2012) Laura Connelly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Multivariate Analyses of Amyloid-Beta Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity

(2012) Panchika Prangkio et al.   PLoS One

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

(2012) L. Milanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Selective Molecular Recognition in Amyloid Growth and Transmission and Cross-Species Barriers

(2011) Buyong Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

Developing β-secretase inhibitors for treatment of Alzheimer’s disease

(2011) Arun K. Ghosh et al.   JOURNAL OF NEUROCHEMISTRY

Molecular-Level Examination of Cu2+Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

(2011) Sudhakar Parthasarathy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Structural Model of Aβ40Fibrils

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antimicrobial Properties of Amyloid Peptides

(2011) Bruce L. Kagan et al.   MOLECULAR PHARMACEUTICS

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Simultaneous Single-Molecule Fluorescence and Conductivity Studies Reveal Distinct Classes of Aβ Species on Lipid Bilayers

(2010) Joseph A. Schauerte et al.   BIOCHEMISTRY

Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

(2010) Yifat Miller et al.   CHEMICAL REVIEWS

Disposition and Metabolism of Semagacestat, a  -Secretase Inhibitor, in Humans

(2010) P. Yi et al.   DRUG METABOLISM AND DISPOSITION

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

(2010) Thimmappa S. Anekonda et al.   NEUROBIOLOGY OF DISEASE

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc ions promote Alzheimer A  aggregation via population shift of polymorphic states

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

(2009) Randall J. Bateman et al.   ANNALS OF NEUROLOGY

Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels

(2009) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation

(2009) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K3 Fragment of Amyloidogenic β2-Microglobulin Forms Ion Channels: Implication for Dialysis Related Amyloidosis

(2009) Mirela Mustata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity

(2009) Giuseppe D. Ciccotosto et al.   NEUROBIOLOGY OF AGING

Amyloid-β-Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy

(2009) Ricardo Capone et al.   NEUROTOXICITY RESEARCH

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thematic Minireview Series on the Molecular Basis of Alzheimer Disease

(2008) Kenneth E. Neet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New structures help the modeling of toxic amyloidß ion channels

(2008) Hyunbum Jang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING