Targeting Toll-like receptors with small molecule agents

Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex

(2012) Kui Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors

(2012) Shuting Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New developments in Toll-like receptor targeted therapeutics

(2012) Dympna J Connolly et al.   CURRENT OPINION IN PHARMACOLOGY

Sensing of microbial molecular patterns by Toll-like receptors

(2012) Dong Hyun Song et al.   IMMUNOLOGICAL REVIEWS

Structure–Activity Relationships in Human Toll-like Receptor 2-Specific Monoacyl Lipopeptides

(2012) Deepak B. Salunke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

Genetic variation in Toll-like receptors and disease susceptibility

(2012) Mihai G Netea et al.   NATURE IMMUNOLOGY

Plant-Based Modulation of Toll-like Receptors: An Emerging Therapeutic Model

(2012) Dev S. Chahal et al.   PHYTOTHERAPY RESEARCH

Synthetic Toll Like Receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants

(2012) Arulkumaran Shanmugam et al.   PLoS One

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chitohexaose Activates Macrophages by Alternate Pathway through TLR4 and Blocks Endotoxemia

(2012) Santosh K. Panda et al.   PLoS Pathogens

Structural Biology of the Toll-Like Receptor Family

(2011) Jin Young Kang et al.   Annual Review of Biochemistry

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

An MD2 Hot-Spot-Mimicking Peptide that Suppresses TLR4-Mediated Inflammatory Response in vitro and in vivo

(2011) Liping Liu et al.   CHEMBIOCHEM

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Toll-like receptor modulators: a patent review (2006 – 2010)

(2011) Shaherin Basith et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface

(2011) V. Y. Toshchakov et al.   JOURNAL OF IMMUNOLOGY

Development of β-Amino Alcohol Derivatives That Inhibit Toll-like Receptor 4 Mediated Inflammatory Response as Potential Antiseptics

(2011) Sherry A. Chavez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships in Toll-Like Receptor 2-Agonists Leading to Simplified Monoacyl Lipopeptides

(2011) Geetanjali Agnihotri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule Inhibitors of the TLR3/dsRNA Complex

(2011) Kui Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals

(2011) Ling Zhao et al.   NUTRITION REVIEWS

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein–protein interactions

(2010) Catherine Joce et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Structure−Activity Relationships in Toll-like Receptor-2 Agonistic Diacylthioglycerol Lipopeptides

(2010) Wenyan Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences

(2010) M.R. Hutchinson et al.   NEUROSCIENCE

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Peptide Antagonist of the TLR4-MD2 Interaction

(2009) Peter F. Slivka et al.   CHEMBIOCHEM

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Taxanes inhibit human TLR4 signaling by binding to MD-2

(2008) Nuša Resman et al.   FEBS LETTERS

Paclitaxel Binding to Human and Murine MD-2

(2008) Shanta M. Zimmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY