Review
Chemistry, Applied
Sheng Zhang, Yoshinori Yamamoto, Ming Bao
Summary: Utilizing palladium intermediates for aromatic functionalization reactions is a challenging and significant research topic, as it enables selective functionalization reactions on aromatic rings while inhibiting the formation of traditional products.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Food Science & Technology
Lina Sheng, Xiran Li, Luxin Wang
Summary: PDI is a promising technology for mitigating foodborne illnesses, food loss and waste, and the occurrence of antibiotic-resistant bacteria. The review summarizes the antimicrobial mechanisms of PDI against food-related microorganisms, highlighting its efficiency in disrupting cell structure and function, oxidation of macromolecules, and inhibition of quorum sensing. Further research is needed to investigate long-term impacts and optimize application parameters for advanced application in food systems.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sergey A. Siletsky, Vitaliy B. Borisov
Summary: Terminal respiratory oxidases are efficient molecular machines that play crucial roles in energy transfer and cell survival. Different types of oxidases have diverse origins and functional significances, yet they all share the ability to avoid the formation of dangerous substances while reducing oxygen to water. Recent advancements in studying their structures and functions are crucial for understanding their roles in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Applied
Forrest Nichols, Kenneth I. Ozoemena, Shaowei Chen
Summary: Controlling microbial proliferation in water systems is crucial for societal health, and electrochemically generated reactive species (RS) provide an effective method for microbial control. This article provides an overview of the progress in electrocatalytic generation of RS and their application in water disinfection. The selective production of RS, the interactions between RS and microorganisms, and the practical implementation of electrochemically generated RS for microbial inactivation are discussed. The article concludes by highlighting the challenges, opportunities, and future research directions in RS-based electrochemical disinfection of water.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Pharmacology & Pharmacy
Lloyd Wei Tat Tang, Ravi Kumar Verma, Ren Ping Yong, Xin Li, Lili Wang, Qingsong Lin, Hao Fan, Eric Chun Yong Chan
Summary: The study demonstrates that while BBR can inactivate CYP3A4, it does not inactivate CYP3A5, and it can activate CYP3A5 reversibly. This finding further reveals the molecular determinants of the interactions between these two isoforms.
MOLECULAR PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Yungen Liu, Ka-Pan Shing, Vanessa Kar-Yan Lo, Chi-Ming Che
Summary: Transition-metal-catalyzed direct C-N bond formation reactions have been widely used for the synthesis of nitrogen-containing compounds. Iron catalysts are promising due to their cost-effectiveness and environmental sustainability, while ruthenium complexes provide more stability for studying the reaction mechanism. This Perspective summarizes the recent developments in iron and ruthenium complexes supported by macrocyclic or polydentate ligands for catalytic amination reactions involving metal imido/nitrene intermediates, and discusses the current limitations and potential opportunities for future research.
Article
Chemistry, Physical
Xuan Gong, Yiru Ye, Abhishek Dutta Chowdhury
Summary: The philosophy of Ikigai, which emphasizes the reason for being, can be applied to understand the role of organic reaction intermediates in zeolite catalysis. These intermediates can either control the product selectivity or promote catalyst deactivation depending on the specific microenvironment in zeolite. The understanding of reaction intermediates and their true impact during catalysis is crucial for the development of zeolite-mediated catalytic technologies.
Article
Environmental Sciences
Jia-Yue Wang, Jing-Xin Li, Jing Ning, Xiao-Kui Huo, Zhen-Long Yu, Yan Tian, Bao-Jing Zhang, Yan Wang, Deng Sa, Ya-Chen Li, Xia Lv, Xiao-Chi Ma
Summary: This study investigates the oxidative metabolism of Dimethomorph (DMM) mediated by the human cytochrome P450 enzyme (CYP) and its toxicological effects. The study reveals that DMM is mainly metabolized through a two-step oxidation process mediated by CYP3A, and can cause mechanism-based inactivation (MBI) of CYP3A. Additionally, other common fungicides can inhibit the metabolism of DMM, leading to increased exposure to DMM in vivo.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Multidisciplinary
Floor ter Braak, Hidde Elferink, Kas J. Houthuijs, Jos Oomens, Jonathan Martens, Thomas J. Boltje
Summary: Understanding the structure and stability of difficult-to-characterize ionic intermediates, such as glycosyl cations, is crucial for studying reaction mechanisms. By combining mass spectrometry with infrared ion spectroscopy, the gas-phase structures of glycosyl cations have been determined, providing valuable insights into their reactivity.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Engineering, Environmental
Yu Zeng, Guodong Fang, Qinglong Fu, Dionysios D. Dionysiou, Xiaolei Wang, Juan Gao, Dongmei Zhou, Yujun Wang
Summary: This study investigated the photochemical processes in paddy water, identifying DOM-D-3*, O-1(2), and OH· as the main reactive intermediates with quantified quantum yields and steady-state concentrations. The findings demonstrated that DOM properties and nitrite concentration were key factors influencing RIs generation, and RIs significantly enhanced arsenite oxidation in paddy water. The study provides new insights into arsenite abiotic transformation pathways in paddy soil and water.
Article
Food Science & Technology
Yi-Ming Zhao, Shikha Ojha, Catherine M. Burgess, Da-Wen Sun, Brijesh K. Tiwari
Summary: This study found that the inactivation efficacy of PAW was positively correlated with plasma treatment time and bacterial exposure time, with Gram-negative species being more sensitive to PAW than Gram-positive species. Bacteria showed cell structure damage after treatment with PAW, accompanied by acidification of pH and increase in conductivity.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
An Le, Kai J. Huang, Lauren R. Cirrincione
Summary: This article synthesizes available in vitro and animal model data with pharmacological concepts in transgender medicine to predict potential effects of sex steroids on drug-metabolizing enzymes and their relationship with potential hormone-drug interactions.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Engineering, Environmental
Kaige Song, Hui Wang, Zhi Jiao, Guangzhou Qu, Weichao Chen, Gaoxue Wang, Tiecheng Wang, Zengqiang Zhang, Fei Ling
Summary: The study demonstrated that pulsed corona discharge plasma (PCDP) can effectively inactivate waterborne viruses, such as SVCV, by damaging their genome and structural proteins. The research also showed that the inactivation efficiency was significantly improved by high input energy density caused by voltage. This has implications for waterborne virus removal and the development of novel disinfection technologies.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Cardiac & Cardiovascular Systems
Elena Dolmatova, Keke Wang, Rohan Mandavilli, Kathy K. Griendling
Summary: Endothelial cells play a crucial role in sepsis by amplifying immune responses and activating the coagulation system. They act as both a target and source of inflammation, linking local and systemic immune responses.
CARDIOVASCULAR RESEARCH
(2021)
Article
Engineering, Environmental
Pin Wang, Lingjun Bu, Yangtao Wu, Jing Deng, Shiqing Zhou
Summary: This study combined theoretical calculations and experimental studies to investigate the kinetics and mechanism of radical-mediated degradation of paracetamol in the UV/monochloramine process, providing deep insights into the degradation mechanism. The study identified the impact factors and reaction mechanisms of various radicals on the degradation of paracetamol, enriching the understanding of the paracetamol degradation mechanism.