Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5

Mechanism-based Inactivation of Cytochrome P450 3A4 by Benzbromarone

(2021) Lloyd Wei Tat Tang et al.   MOLECULAR PHARMACOLOGY

Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

(2020) John T. Barr et al.   DRUG METABOLISM AND DISPOSITION

Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4

(2019) Mei-Hui Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4

(2019) Xiucai Guo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Glutathione conjugation and protein adduction derived from oxidative debromination of benzbromarone in mice

(2019) Hui Wang et al.   DRUG METABOLISM AND DISPOSITION

PubChem 2019 update: improved access to chemical data

(2018) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5

(2017) Mei-Hui Hsu et al.   MOLECULAR PHARMACOLOGY

Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases

(2017) Jun-Xian Wang et al.   TOXICOLOGY LETTERS

Docking Covalent Inhibitors: A Parameter Free Approach To Pose Prediction and Scoring

(2014) Kai Zhu et al.   Journal of Chemical Information and Modeling

The RCSB Protein Data Bank: views of structural biology for basic and applied research and education

(2014) Peter W. Rose et al.   NUCLEIC ACIDS RESEARCH

Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems

(2012) Irina F. Sevrioukova et al.   DALTON TRANSACTIONS

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib

(2011) Pei-pei Dong et al.   ACTA PHARMACOLOGICA SINICA

Sorafenib and Sunitinib, Two Anticancer Drugs, Inhibit CYP3A4-Mediated and Activate CY3A5-Mediated Midazolam 1'-Hydroxylation

(2011) M. Sugiyama et al.   DRUG METABOLISM AND DISPOSITION

Mechanism of cytochrome P450-3A inhibition by ketoconazole

(2011) David J. Greenblatt et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

(2010) I. F. Sevrioukova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5

(2008) Y. Okada et al.   DRUG METABOLISM AND DISPOSITION

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY