Exploring physicochemical space via a bioisostere of the trifluoromethyl and ethyl groups (BITE): attenuating lipophilicity in fluorinated analogues of Gilenya® for multiple sclerosis

Informing Molecular Design by Stereoelectronic Theory: The Fluorine Gauche Effect in Catalysis

(2018) Marialuisa Aufiero et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Partially fluorinated alkoxy groups − Conformational adaptors to changing environments

(2017) Quentin A. Huchet et al.   JOURNAL OF FLUORINE CHEMISTRY

Deconstructing the Catalytic, Vicinal Difluorination of Alkenes: HF-Free Synthesis and Structural Study of p-TolIF2

(2017) Jérôme C. Sarie et al.   JOURNAL OF ORGANIC CHEMISTRY

Accurate Lipophilicity (log P ) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry

(2016) David O'Hagan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Fluorine Gauche Effect: A Brief History

(2016) Christian Thiehoff et al.   ISRAEL JOURNAL OF CHEMISTRY

The influence of electronic perturbations on the Sulfur–Fluorine Gauche Effect

(2016) Christian Thiehoff et al.   JOURNAL OF FLUORINE CHEMISTRY

Catalytic Difluorination of Olefins

(2016) István Gábor Molnár et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic, Diastereoselective 1,2-Difluorination of Alkenes

(2016) Steven M. Banik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multiple sclerosis prevalence in the United States commercially insured population

(2016) Piyameth Dilokthornsakul et al.   NEUROLOGY

The Sulfur–Fluorine Gauche Effect in Coinage-Metal Complexes: Augmenting Conformational Equilibria by Complexation

(2016) Nico Santschi et al.   ORGANOMETALLICS

Catalytic, Vicinal Difluorination of Olefins: Creating a Hybrid, Chiral Bioisostere of the Trifluoromethyl and Ethyl Groups

(2016) István G. Molnár et al.   ACS Catalysis

Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method

(2015) Bruno Linclau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: Sandmeyer-Type Trifluoromethylthiolation and Trifluoromethylselenolation of (Hetero)Aromatic Amines Catalyzed by Copper (Chem. Eur. J. 1/2016)

(2015) Christian Matheis et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organofluorine chemistry: applications, sources and sustainability

(2015) Antal Harsanyi et al.   GREEN CHEMISTRY

Synthesis and Evaluation of Fluorinated Fingolimod (FTY720) Analogues for Sphingosine-1-Phosphate Receptor Molecular Imaging by Positron Emission Tomography

(2015) Rizwan S. Shaikh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

(2015) Quentin A. Huchet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Can acyclic conformational control be achieved via a sulfur–fluorine gauche effect?

(2015) C. Thiehoff et al.   Chemical Science

Current Perspectives on Interferon Beta-1b for the Treatment of Multiple Sclerosis

(2014) Martin Marziniak et al.   ADVANCES IN THERAPY

Simple Vector Considerations to Assess the Polarity of Partially Fluorinated Alkyl and Alkoxy Groups

(2014) Klaus Müller   CHIMIA

Established and novel disease-modifying treatments in multiple sclerosis

(2014) A. H. Cross et al.   JOURNAL OF INTERNAL MEDICINE

On the polarity of partially fluorinated methyl groups

(2013) Quentin A. Huchet et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis of novel therapeutic agents for the treatment of multiple sclerosis: A brief overview

(2012) Naveen Mulakayala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluorine Conformational Effects in Organocatalysis: An Emerging Strategy for Molecular Design

(2011) Lucie E. Zimmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorinated amino acids: compatibility with native protein structures and effects on protein–protein interactions

(2011) Mario Salwiczek et al.   CHEMICAL SOCIETY REVIEWS

Fingolimod

(2011) Lesley J. Scott   CNS DRUGS

Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite

(2011) Cherilyn R. Strader et al.   JOURNAL OF NATURAL PRODUCTS

Treatment of multiple sclerosis: current concepts and future perspectives

(2011) Dorothea Buck et al.   JOURNAL OF NEUROLOGY

The C–F bond as a conformational tool in organic and biological chemistry

(2010) Luke Hunter   Beilstein Journal of Organic Chemistry

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Using the Golden Triangle to optimize clearance and oral absorption

(2009) Ted W. Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assessing the Bioisosterism of the Trifluoromethyl Group with a Protease Probe

(2008) Monika Jagodzinska et al.   ChemMedChem

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS