Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs

Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats

(2012) Adam R. Mezo et al.   BIOCONJUGATE CHEMISTRY

Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

(2012) Martin J. Weissenborn et al.   CHEMICAL COMMUNICATIONS

Simplifying native chemical ligation with an N-acylsulfonamide linker

(2012) Fabienne Burlina et al.   CHEMICAL COMMUNICATIONS

A New Benzotriazole-Mediated Stereoflexible Gateway to Hetero-2,5-diketopiperazines

(2012) Jean-Christophe M. Monbaliu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design of β-Amyloid Aggregation Inhibitors from a Predicted Structural Motif

(2012) Paul A. Novick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long-Range Intramolecular S → N Acyl Migration: A Study of the Formation of Native Peptide Analogues via 13-, 15-, and 16-Membered Cyclic Transition States

(2012) Khanh Ha et al.   JOURNAL OF ORGANIC CHEMISTRY

Native chemical ligation in dimethylformamide can be performed chemoselectively without racemization

(2012) Marc Dittmann et al.   JOURNAL OF PEPTIDE SCIENCE

Interrogation of MDM2 Phosphorylation in p53 Activation Using Native Chemical Ligation: The Functional Role of Ser17 Phosphorylation in MDM2 Reexamined

(2012) Changyou Zhan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Carrier Protein Strategy Yields the Structure of Dalbavancin

(2012) Nicoleta J. Economou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of the α-Subunit of Human Glycoprotein Hormones: Toward Fully Synthetic Homogeneous Human Follicle-Stimulating Hormone

(2012) Baptiste Aussedat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Synthesis of Homogeneous Human Glycosyl-interferon-β That Exhibits Potent Antitumor Activity in Vivo

(2012) Izumi Sakamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Native Chemical Ligation of Thioamide-Containing Peptides: Development and Application to the Synthesis of Labeled α-Synuclein for Misfolding Studies

(2012) Solongo Batjargal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ionic Liquid Applications in Peptide Chemistry: Synthesis, Purification and Analytical Characterization Processes

(2012) Alesia A. Tietze et al.   MOLECULES

Traceless chemical ligations from O-acyl serine sites

(2012) Mirna El Khatib et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of a Dicarba Analogue of Human β-Defensin-1 Using a Combined Ring Closing Metathesis–Native Chemical Ligation Strategy

(2012) Amanda M. Heapy et al.   ORGANIC LETTERS

Synthesis of the Bacteriocin Glycopeptide Sublancin 168 and S-Glycosylated Variants

(2012) Yves S. Y. Hsieh et al.   ORGANIC LETTERS

Access to Cyclic or Branched Peptides Using Bis(2-sulfanylethyl)amido Side-Chain Derivatives of Asp and Glu

(2012) Emmanuelle Boll et al.   ORGANIC LETTERS

Native Chemical Ligation at Glutamine

(2012) Peter Siman et al.   ORGANIC LETTERS

Chemoselectivity in Chemical Biology: Acyl Transfer Reactions with Sulfur and Selenium

(2011) Nicholas A. McGrath et al.   ACCOUNTS OF CHEMICAL RESEARCH

Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein

(2011) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Chemical Synthesis of an Integral Membrane Enzyme: Diacylglycerol Kinase fromEscherichia coli

(2011) Sunanda Lahiri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

(2011) Nathalie Ollivier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Convergent Chemical Synthesis of [Lysine24, 38, 83] Human Erythropoietin

(2011) Suhuai Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preformed Selenoesters Enable Rapid Native Chemical Ligation at Intractable Sites

(2011) Thomas Durek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor

(2011) Kalyaneswar Mandal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Use of Model Peptide Reactions for the Characterization of Kinetically Controlled Ligation

(2011) Joongoo Lee et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Characterization of Dendron Cross-Linked PEG Hydrogels as Corneal Adhesives

(2011) Abigail M. Oelker et al.   BIOMACROMOLECULES

Application of N–C- or C–N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation

(2011) Kohei Tsuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

‘Click peptide’ using production of monomer Aβ from the O-acyl isopeptide: Application to assay system of aggregation inhibitors and cellular cytotoxicity

(2011) Youhei Sohma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ascorbate as an Alternative to Thiol Additives in Native Chemical Ligation

(2011) Heike Rohde et al.   CHEMBIOCHEM

Click Peptide Concept: O-Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule

(2011) Taku Yoshiya et al.   CHEMBIOCHEM

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

(2011) Paul P. Geurink et al.   CHEMBIOCHEM

N-Sulfanylethylanilide Peptide as a Crypto-Thioester Peptide

(2011) Kohei Sato et al.   CHEMBIOCHEM

Semi-synthesis of a protease-activatable collagen targeting probe

(2011) Monica Breurken et al.   CHEMICAL COMMUNICATIONS

Recent advances in micro reaction technology

(2011) Charlotte Wiles et al.   CHEMICAL COMMUNICATIONS

Peptide Coupling Reagents, More than a Letter Soup

(2011) Ayman El-Faham et al.   CHEMICAL REVIEWS

Microwave heating in solid-phase peptide synthesis

(2011) Søren L. Pedersen et al.   CHEMICAL SOCIETY REVIEWS

Theoretical Analysis of the Detailed Mechanism of Native Chemical Ligation Reactions

(2011) Chen Wang et al.   Chemistry-An Asian Journal

Synthesis and Functional Characterization of Tridegin and Its Analogues: Inhibitors and Substrates of Factor XIIIa

(2011) Miriam Böhm et al.   ChemMedChem

Synthesis of Peptide Alkylthioesters Using the IntramolecularN,S-Acyl Shift Properties of Bis(2-sulfanylethyl)amido Peptides

(2011) Julien Dheur et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemical synthesis of the third WW domain of TCERG 1 by native chemical ligation

(2011) Zerrin Fidan et al.   JOURNAL OF PEPTIDE SCIENCE

Fmoc Synthesis of Peptide Thioesters without Post-Chain-Assembly Manipulation

(2011) Ji-Shen Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Advance in Proline Ligation

(2011) Shiying Shang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrated SPPS on continuous-flow radial microfluidic chip

(2011) Weizhi Wang et al.   LAB ON A CHIP

From Polyesters to Polyamides Via ON Acyl Migration: An Original Multi-Transfer Reaction

(2011) Julien Tailhades et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Microwave-assisted chemical ligation of S-acyl peptides containing non-terminal cysteine residues

(2011) Finn K. Hansen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Alternating chemical ligation reactivity of S-acyl peptides explained with theory and computations

(2011) Alexander A. Oliferenko et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Site-specific protein double labeling by expressed protein ligation: applications to repeat proteins

(2011) Lucia De Rosa et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Thiazolidine Thioester Peptides and Acceleration of Native Chemical Ligation

(2011) Julien Dheur et al.   ORGANIC LETTERS

Dual Kinetically Controlled Native Chemical Ligation Using a Combination of Sulfanylproline and Sulfanylethylanilide Peptide

(2011) Hao Ding et al.   ORGANIC LETTERS

N-to-C Sequential Ligation Using Peptidyl N,N-Bis(2-mercaptoethyl)amide Building Blocks

(2011) Renliang Yang et al.   ORGANIC LETTERS

Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O–N acyl transfer

(2011) Akira Shigenaga et al.   TETRAHEDRON

Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide

(2011) Youhei Sohma et al.   TETRAHEDRON LETTERS

Solution-phase synthesis of chiral O-acyl isodipeptides

(2011) Mirna El Khatib et al.   MedChemComm

Insights into the Finer Issues of Native Chemical Ligation: An Approach to Cascade Ligations

(2010) Zhongping Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Traceless Ligation of Cysteine Peptides Using Selective Deselenization

(2010) Norman Metanis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

9-Fluorenylmethoxycarbonyl-Based Solid-Phase Synthesis of Peptide α-Thioesters

(2010) Franziska Mende et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies

(2010) Toru Nakahara et al.   BIOCONJUGATE CHEMISTRY

Invited reviewligation-Desulfurization: A powerful combination in the synthesis of peptides and glycopeptides

(2010) Heike Rohde et al.   BIOPOLYMERS

Native chemical ligation with Nα acyl transfer auxiliaries

(2010) John Offer   BIOPOLYMERS

S-acyl isopeptide method: Use of allyl-type protective group for improved preparation of thioester-containing S-acyl isopeptides by Fmoc-based SPPS

(2010) Taku Yoshiya et al.   BIOPOLYMERS

Chemical Synthesis and Structure of the Prokineticin Bv8

(2010) Rodrigo A. V. Morales et al.   CHEMBIOCHEM

Protein Synthesis Assisted by Native Chemical Ligation at Leucine

(2010) Ziv Harpaz et al.   CHEMBIOCHEM

Total chemical synthesis of human proinsulin

(2010) Samuel Luisier et al.   CHEMICAL COMMUNICATIONS

Synthesis of histone H3 proteins by a thioacid capture ligation strategy

(2010) Xiaohong Zhang et al.   CHEMICAL COMMUNICATIONS

An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation

(2010) Samuel B. Pollock et al.   CHEMICAL COMMUNICATIONS

Chemical Ligation of S-Scylated Cysteine Peptides to Form Native Peptides via 5-, 11-, and 14-Membered Cyclic Transition States‡

(2010) Alan R. Katritzky et al.   JOURNAL OF ORGANIC CHEMISTRY

Native chemical ligation of hydrophobic peptides in organic solvents

(2010) Marc Dittmann et al.   JOURNAL OF PEPTIDE SCIENCE

The depsipeptide method for solid-phase synthesis of difficult peptides

(2010) Irene Coin   JOURNAL OF PEPTIDE SCIENCE

Energetics of the Lighter Chalcogen Analogues of Carboxylic Acid Esters†

(2010) Carol A. Deakyne et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ester to Amide Switch Peptides Provide a Simple Method for Preparing Monomeric Islet Amyloid Polypeptide under Physiologically Relevant Conditions and Facilitate Investigations of Amyloid Formation

(2010) Ping Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The chemical ligation of selectively S-acylated cysteine peptides to form native peptides via 5-, 11- and 14-membered cyclic transition states

(2010) Alan R. Katritzky et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bis(2-sulfanylethyl)amino Native Peptide Ligation

(2010) Nathalie Ollivier et al.   ORGANIC LETTERS

A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides

(2010) Jin Chen et al.   TETRAHEDRON

Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element

(2010) Hironobu Hojo et al.   TETRAHEDRON LETTERS

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

Highly Efficient and Chemoselective Peptide Ubiquitylation

(2009) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides

(2009) Matthias Meier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of amyloid β peptide 1–42 (E22Δ) click peptide: pH-triggered in situ production of its native form

(2009) Hui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 4-mercapto-l-lysine derivatives: Potential building blocks for sequential native chemical ligation

(2009) Kalyan Kumar Pasunooti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

“Click Peptide“: pH-Triggered in Situ Production and Aggregation of Monomer Aβ1-42

(2009) Atsuhiko Taniguchi  et al.   CHEMBIOCHEM

Phosphate-assisted peptide ligation

(2009) Gemma L. Thomas et al.   CHEMICAL COMMUNICATIONS

Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins

(2009) Richard J. Payne et al.   CHEMICAL COMMUNICATIONS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Internal Cysteine Accelerates Thioester-Based Peptide Ligation

(2009) Christian Haase et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective Synthesis and Structural Elucidation ofS-Acyl- andN-Acylcysteines

(2009) Alan R. Katritzky et al.   JOURNAL OF ORGANIC CHEMISTRY

Dual Native Chemical Ligation at Lysine

(2009) Renliang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O-Acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation

(2009) Taku Yoshiya et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Controlled in situ preparation of Aβ(1–42) oligomers from the isopeptide “iso-Aβ(1–42)”, physicochemical and biological characterization

(2009) Zsolt Bozso et al.   PEPTIDES

Kinetics and mechanism of the aminolysis of thioesters and thiocarbonates in solution

(2009) Enrique A. Castro   PURE AND APPLIED CHEMISTRY

Chiral Acylation with N-(Protected α-Aminoacyl)benzotriazoles for Advantageous Syntheses of Peptides and Peptide Conjugates

(2009) Alan Katritzky et al.   SYNLETT

Chemoselective Ligation and Modification Strategies for Peptides and Proteins

(2008) Christian P. R. Hackenberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Efficient Fmoc-SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation

(2008) Juan B. Blanco-Canosa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Uncovering a Latent Ligation Site for Glycopeptide Synthesis

(2008) Ryo Okamoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Protein Splicing by Protease- or Light-Triggered O to N Acyl Migration

(2008) Miquel Vila-Perelló et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis

(2008) Jin Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native Chemical Ligation at Valine

(2008) Christian Haase et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple Method for Preparing Peptide C-Terminal Thioacids and Their Application in Sequential Chemoenzymatic Ligation

(2008) Xiao-Hong Tan et al.   CHEMBIOCHEM

Switch-Peptides: Design and Characterization of Controllable Super-Amyloid-Forming Host-Guest Peptides as Tools for Identifying Anti-Amyloid Agents

(2008) Marie-Stéphanie Camus et al.   CHEMBIOCHEM

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Amide bond formation: beyond the myth of coupling reagents

(2008) Eric Valeur et al.   CHEMICAL SOCIETY REVIEWS

Expanding the scope of chemoselective peptide ligations in chemical biology

(2008) Anouk Dirksen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Application of Dmb-Dipeptides in the Fmoc SPPS of Difficult and Aspartimide-Prone Sequences

(2008) V. Cardona et al.   International Journal of Peptide Research and Therapeutics

Isopeptide method: development ofS-acyl isopeptide method for the synthesis of difficult sequence-containing peptides

(2008) Taku Yoshiya et al.   JOURNAL OF PEPTIDE SCIENCE

Switching from the unfolded to the folded state of the helix-loop-helix domain of the Id proteins based on theO-acyl isopeptide method

(2008) Sebastian D. Kiewitz et al.   JOURNAL OF PEPTIDE SCIENCE

NMR and Theoretical Calculations: A Unified View of the Cis/Trans Isomerization of 2-Substituted Thiazolidines Containing Peptides

(2008) Helene Jamet et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Oxo-ester Mediated Native Chemical Ligation: Concept and Applications

(2008) Qian Wan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical synthesis and semisynthesis of membrane proteins

(2008) Diana Olschewski et al.   Molecular BioSystems

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

Switch Peptide via Staudinger Reaction

(2008) Natalia Nepomniaschiy et al.   ORGANIC LETTERS

The concept of internal solubilization in peptide synthesis: ethylene glycol-based protecting groups

(2008) László Kocsis et al.   TETRAHEDRON LETTERS

Synthesis of cyclic peptides via O–N-acyl migration

(2008) Jennifer Lécaillon et al.   TETRAHEDRON LETTERS

The depsipeptide technique applied to peptide segment condensation: Scope and limitations

(2007) Irene Coin et al.   JOURNAL OF PEPTIDE SCIENCE