Theoretical Analysis of the Detailed Mechanism of Native Chemical Ligation Reactions

Towards biomolecular assembly employing extended native chemical ligation in combination with thioester synthesis using an N→S acyl shift

(2010) Tom Ackrill et al.   BIOPOLYMERS

Native chemical ligation with Nα acyl transfer auxiliaries

(2010) John Offer   BIOPOLYMERS

Chemical Protein Synthesis by Kinetically Controlled Ligation of Peptide O-Esters

(2010) Ji-Shen Zheng et al.   CHEMBIOCHEM

Chemoselective Ligation of Peptide Phenyl Esters with N-Terminal Cysteines

(2010) Ge-Min Fang et al.   CHEMBIOCHEM

Protein Synthesis Assisted by Native Chemical Ligation at Leucine

(2010) Ziv Harpaz et al.   CHEMBIOCHEM

Semisynthetic Src SH2 Domains Demonstrate Altered Phosphopeptide Specificity Induced by Incorporation of Unnatural Lysine Derivatives

(2010) Satpal Virdee et al.   CHEMISTRY & BIOLOGY

Transition States and Origins of 1,4-Asymmetric Induction in Alkylations of 2,2,6-Trialkylpiperidine Enamines

(2010) Joann M. Um et al.   CHEMISTRY-A EUROPEAN JOURNAL

First-Principles Prediction of Nucleophilicity Parameters for π Nucleophiles: Implications for Mechanistic Origin of Mayr’s Equation

(2010) Chen Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Computational Investigation of the Reaction Mechanisms of Nitroxyl and Thiols

(2010) Matthew P. Sherman et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Decarboxylative Couplings of 2-(2-Azaaryl)acetates with Aryl Halides and Triflates

(2010) Rui Shang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origins of Regioselectivity and Alkene-Directing Effects in Nickel-Catalyzed Reductive Couplings of Alkynes and Aldehydes

(2010) Peng Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computation-Guided Development of Au-Catalyzed Cycloisomerizations Proceeding via 1,2-Si or 1,2-H Migrations: Regiodivergent Synthesis of Silylfurans

(2010) Alexander S. Dudnik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Investigation of the Mechanism of C(sp3)−H Bond Cleavage in Pd(0)-Catalyzed Intramolecular Alkane Arylation Adjacent to Amides and Sulfonamides

(2010) Sophie Rousseaux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origins of the Selectivity for Borylation of Primary over Secondary C−H Bonds Catalyzed by Cp*-Rhodium Complexes

(2010) Carolyn S. Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide and protein thioester synthesis via N→S acyl transfer

(2010) Jaskiranjit Kang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The chemical ligation of selectively S-acylated cysteine peptides to form native peptides via 5-, 11- and 14-membered cyclic transition states

(2010) Alan R. Katritzky et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pd-Catalyzed Decarboxylative Cross Coupling of Potassium Polyfluorobenzoates with Aryl Bromides, Chlorides, and Triflates

(2010) Rui Shang et al.   ORGANIC LETTERS

Salicylaldehyde Ester-Induced Chemoselective Peptide Ligations: Enabling Generation of Natural Peptidic Linkages at the Serine/Threonine Sites

(2010) Xuechen Li et al.   ORGANIC LETTERS

Sequential native chemical ligation utilizing peptide thioacids derived from newly developed Fmoc-based synthetic method

(2010) Akira Shigenaga et al.   TETRAHEDRON

A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides

(2010) Jin Chen et al.   TETRAHEDRON

Peptide ligation assisted by an auxiliary attached to amidyl nitrogen

(2010) Juan Li et al.   TETRAHEDRON LETTERS

Wrestling with Native Chemical Ligation

(2009) Hagan Bayley et al.   ACS Chemical Biology

Combined Approaches to the Synthesis and Study of Glycoproteins

(2009) Gonçalo J. L. Bernardes et al.   ACS Chemical Biology

Highly Efficient and Chemoselective Peptide Ubiquitylation

(2009) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Pyrrolysine Analogue for Site-Specific Protein Ubiquitination

(2009) Xin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Semisynthesis of a Homogeneous Glycoprotein Enzyme: Ribonuclease C: Part 1

(2009) Christian Piontek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods

(2009) Kiriko Hirano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 4-mercapto-l-lysine derivatives: Potential building blocks for sequential native chemical ligation

(2009) Kalyan Kumar Pasunooti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Side-chain assisted ligation in protein synthesis

(2009) K.S. Ajish Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Semisynthetic Strategy to Generate Phosphorylated and Acetylated Histone H2B

(2009) Kyle P. Chiang et al.   CHEMBIOCHEM

Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins

(2009) Richard J. Payne et al.   CHEMICAL COMMUNICATIONS

Backbone Amide Linker in Solid-Phase Synthesis

(2009) Ulrik Boas et al.   CHEMICAL REVIEWS

Brønsted Acid Catalyzed Morita-Baylis-Hillman Reaction: A New Mechanistic View for Thioureas Revealed by ESI-MS(/MS) Monitoring and DFT Calculations

(2009) Giovanni W. Amarante et al.   CHEMISTRY-A EUROPEAN JOURNAL

Internal Cysteine Accelerates Thioester-Based Peptide Ligation

(2009) Christian Haase et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient Substitution Reaction from Cysteine to the Serine Residue of Glycosylated Polypeptide: Repetitive Peptide Segment Ligation Strategy and the Synthesis of Glycosylated Tetracontapeptide Having Acid Labile Sialyl-TNAntigens

(2009) Ryo Okamoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective Synthesis and Structural Elucidation ofS-Acyl- andN-Acylcysteines

(2009) Alan R. Katritzky et al.   JOURNAL OF ORGANIC CHEMISTRY

Theoretical Study on Acidities of (S)-Proline Amide Derivatives in DMSO and Its Implications for Organocatalysis

(2009) Xiong-Yi Huang et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1−Gly28Glycopeptide Domain by “Alanine” Ligation

(2009) Cindy Kan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys29−Gly77Glycopeptide Domain

(2009) Yu Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ring Strain Energy in the Cyclooctyl System. The Effect of Strain Energy on [3 + 2] Cycloaddition Reactions with Azides

(2009) Robert D. Bach   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thio FCMA Intermediates as Strong Acyl Donors: A General Solution to the Formation of Complex Amide Bonds

(2009) Yu Rao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition State Distortion Energies Correlate with Activation Energies of 1,4-Dihydrogenations and Diels−Alder Cycloadditions of Aromatic Molecules

(2009) Amy E. Hayden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward Fully Synthetic Homogeneous β-Human Follicle-Stimulating Hormone (β-hFSH) with a Biantennary N-Linked Dodecasaccharide. Synthesis of β-hFSH with Chitobiose Units at the Natural Linkage Sites

(2009) Pavel Nagorny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Why Is Copper(I) Complex More Competent Than Dirhodium(II) Complex in Catalytic Asymmetric O−H Insertion Reactions? A Computational Study of the Metal Carbenoid O−H Insertion into Water

(2009) Yong Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Theoretical Analysis of Factors Controlling Pd-Catalyzed Decarboxylative Coupling of Carboxylic Acids with Olefins

(2009) Song-Lin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide thioester synthesis through N→S acyl-transfer: application to the synthesis of a β-defensin

(2009) Jaskiranjit Kang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of N-Terminally Linked Protein Dimers and Trimers by a Combined Native Chemical Ligation-CuAAC Click Chemistry Strategy

(2009) Junpeng Xiao et al.   ORGANIC LETTERS

A One-Pot Approach to Neoglycopeptides using Orthogonal Native Chemical Ligation and Click Chemistry

(2009) Dong Jun Lee et al.   ORGANIC LETTERS

N→SAcyl-Transfer-Mediated Synthesis of Peptide Thioesters Using Anilide Derivatives

(2009) Shugo Tsuda et al.   ORGANIC LETTERS

The use of a cysteinyl prolyl ester (CPE) autoactivating unit in peptide ligation reactions

(2009) Toru Kawakami et al.   TETRAHEDRON

High-pressure-promoted Fmoc-aminoacylation of N-ethylcysteine: preparation of key devices for the solid-phase synthesis of peptide thioesters

(2009) Yuko Nakahara et al.   TETRAHEDRON LETTERS

Chemoselective Ligation and Modification Strategies for Peptides and Proteins

(2008) Christian P. R. Hackenberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Extending the Scope of Native Chemical Peptide Coupling

(2008) Christian Haase et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis

(2008) Jin Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native Chemical Ligation at Valine

(2008) Christian Haase et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reprint of “Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site” [Bioorg. Med. Chem. Lett. 18 (2008) 4554-4557]

(2008) Vladimir Yu. Torbeev et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters

(2008) Jaskiranjit Kang et al.   CHEMICAL COMMUNICATIONS

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Solid-Phase Synthesis of Peptide and Glycopeptide Thioesters through Side-Chain-Anchoring Strategies

(2008) Simon Ficht et al.   CHEMISTRY-A EUROPEAN JOURNAL

Computational Evaluation of Enantioselective Diels−Alder Reactions Mediated by Corey’s Cationic Oxazaborolidine Catalysts

(2008) Michael N. Paddon-Row et al.   JOURNAL OF ORGANIC CHEMISTRY

Oxo-ester Mediated Native Chemical Ligation: Concept and Applications

(2008) Qian Wan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclic Peptide Inhibitors of Staphylococcal Virulence Prepared by Fmoc-Based Thiolactone Peptide Synthesis

(2008) Elizabeth A. George et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamics of “Flap” Structures in Three HIV-1 Protease/Inhibitor Complexes Probed by Total Chemical Synthesis and Pulse-EPR Spectroscopy

(2008) Vladimir Yu. Torbeev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation

(2008) Jonathan P. Richardson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Comparative Properties of Insulin-like Growth Factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 Prepared by Total Chemical Synthesis

(2007) Youhei Sohma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single nucleotide specific detection of DNA by native chemical ligation of fluorescence labeled PNA-probes

(2007) Christian Dose et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanism of Thiolate−Disulfide Interchange Reactions in Biochemistry

(2007) Robert D. Bach et al.   JOURNAL OF ORGANIC CHEMISTRY