Unlocked Nucleic Acids with a Pyrene-Modified Uracil: Synthesis, Hybridization Studies, Fluorescent Properties and i-Motif Stability

A quencher-free molecular beacon design based on pyrene excimer fluorescence using pyrene-labeled UNA (unlocked nucleic acid)

(2013) Kasper K. Karlsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting

(2013) Nicholas M Snead et al.   Molecular Therapy-Nucleic Acids

Pyrene-Modified Unlocked Nucleic Acids: Synthesis, Thermodynamic Studies, and Fluorescent Properties

(2012) Kasper K. Karlsen et al.   CHEMBIOCHEM

Unlocking G-quadruplex: Effect of unlocked nucleic acid on G-quadruplex stability

(2011) Tani Agarwal et al.   BIOCHIMIE

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2′-C-piperazino-UNA monomer

(2011) Troels B. Jensen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Monitoring i-motif transitions through the exciplex emission of a fluorescent probe incorporating two PyA units

(2011) Il Joon Lee et al.   CHEMICAL COMMUNICATIONS

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

(2011) Meghan A. Campbell et al.   CHEMICAL SOCIETY REVIEWS

Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and nanotechnology

(2011) Michael E. Østergaard et al.   CHEMICAL SOCIETY REVIEWS

Using fluorescence changes of F1U units at terminal and mid-loop positions to probe i-motif structures

(2011) Il Joon Lee et al.   Molecular BioSystems

Locked and Unlocked Nucleosides in Functional Nucleic Acids

(2011) Holger Doessing et al.   MOLECULES

Unlocked nucleic acid – an RNA modification with broad potential

(2011) Anna Pasternak et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Increasing the Analytical Sensitivity by Oligonucleotides Modified with Para- and Ortho-Twisted Intercalating Nucleic Acids – TINA

(2011) Uffe V. Schneider et al.   PLoS One

Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki–Miyaura cross-coupling reaction

(2011) Yu-Chiao Shih et al.   TETRAHEDRON

Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomers

(2010) Anna Pasternak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

(2010) Arivazhagan Rajendran et al.   CHEMICAL COMMUNICATIONS

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

(2010) Maria B. Laursen et al.   Molecular BioSystems

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

(2010) Narendra Vaish et al.   NUCLEIC ACIDS RESEARCH

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability

(2009) Niels Langkjær et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Probe for i-motif structure and G-rich strands using end-stacking ability

(2009) Il Joon Lee et al.   CHEMICAL COMMUNICATIONS

Nucleic acid-guided assembly of aromatic chromophores

(2009) Vladimir L. Malinovskii et al.   CHEMICAL SOCIETY REVIEWS

Application of small interfering RNAs modified by unlocked nucleic acid (UNA) to inhibit the heart-pathogenic coxsackievirus B3

(2009) Denise Werk et al.   FEBS LETTERS

Synthesis of an Unlocked Nucleic Acid Terpyridine Monomer and Binding of Divalent Metal Ion in Nucleic Acid Duplexes

(2009) Kasper K. Karlsen et al.   JOURNAL OF ORGANIC CHEMISTRY

A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity

(2009) Alexander S. Wahba et al.   NUCLEIC ACIDS RESEARCH

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5′-terminal phosphorylation both in vitro and in vivo

(2009) Denise M. Kenski et al.   NUCLEIC ACIDS RESEARCH

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

The Thermodynamics of 3‘-Terminal Pyrene and Guanosine for the Design of Isoenergetic 2‘-O-Methyl-RNA-LNA Chimeric Oligonucleotide Probes of RNA Structure†

(2008) Anna Pasternak et al.   BIOCHEMISTRY

1-, 2-, and 4-Ethynylpyrenes in the Structure of Twisted Intercalating Nucleic Acids: Structure, Thermal Stability, and Fluorescence Relationship

(2008) Vyacheslav V. Filichev et al.   CHEMISTRY-A EUROPEAN JOURNAL