Article
Cell Biology
Xiuqi Xu, Ziqi Yuan, Shijia Zhang, Guang Li, Guangqin Zhang
Summary: This study observed the changes in the TRPV1 channel in MSU-induced gouty arthritis and found that TRPV1 plays an important role in mediating mechanical hyperalgesia in gouty arthritis. This suggests that TRPV1 could be a potential new target for the clinical treatment of gouty arthritis.
INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Benjamin M. Zemel, Lianteng Zhi, Eric V. Brown, Stephen R. Tymanskyj, Qiansheng Liang, Manuel Covarrubias
Summary: The study suggests that a physical interaction between Kv3.4 channel and functional PKC epsilon primarily determines its stability and localization in DRG neurons, without significantly affecting its gating.
Article
Biochemistry & Molecular Biology
Arsalan Yousuf, Xiaosa Wu, Anuja R. Bony, Mahsa Sadeghi, Yen-Hua Huang, David J. Craik, David J. Adams
Summary: alpha O-Conotoxin GeXIVA, derived from the venom of marine snail Conus generalis, has analgesic activity and acts on GABA(B) receptors, indicating a potential important receptor target for mediating analgesia. The peptide has different structural isomers, with the bead isomer being the most potent at nicotinic acetylcholine receptors.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biology
Peter R. Strege, Luke M. Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A. Ahern, Lorin S. Milescu, Gianrico Farrugia, Arthur Beyder
Summary: Shear stress and patch suction can reversibly alter the kinetic properties and maximum current of NaChBac, suggesting it is mechanosensitive. Structural analysis reveals a large displacement of the intracellular gate, supporting the proposed mechanosensitive mechanism.
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Editorial Material
Biology
Thomas Kaas, Jana Nerlich, Stefan Hallermann
Summary: A new study reveals the involvement of intermediate gating states in calcium channels, shedding light on how analogue postsynaptic potentials affect neurotransmitter release.
Article
Biochemistry & Molecular Biology
Cristina Fraquelli, Jasmine Hauzinger, Christian Humpel, Maria Nolano, Vincenzo Provitera, Vinay Kumar Sharma, Peng Loh, Zenon Pidsudko, Georgios Blatsios, Josef Troger
Summary: This study investigated the presence and source of serpinins in the skin, and found that serpinin was present in the dorsal root ganglia and sensory nerves of rats, with colocalization with substance P. Although predominantly found in its free form in the skin, the serpinins may have functional significance in the sensory innervation of the skin.
Article
Biochemistry & Molecular Biology
Ruirui Lu, Katharina Metzner, Fangyuan Zhou, Cathrin Flauaus, Annika Balzulat, Patrick Engel, Jonas Petersen, Rebekka Ehinger, Anne Bausch, Peter Ruth, Robert Lukowski, Achim Schmidtko
Summary: The sodium-activated potassium channel Slack plays a role in sensory neurons and is involved in mediating sodium-activated potassium current (I-KNa) and modulating neuronal activity. Studies found that Slack activity is reduced in sensory neurons after peripheral nerve injury, contributing to neuropathic pain hypersensitivity, and that it is associated with ATP-sensitive P2X3 receptors. Experiments showed that Slack-mediated I-KNa can be bidirectionally modulated in response to P2X3 activation, suggesting a potential novel strategy for treating neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ying Zhao, Qiang Wang, Chen Xie, Yuling Cai, Xue Chen, Yuhui Hou, Liu He, Jianping Li, Min Yao, Shuangxi Chen, Wutian Wu, Xiaojia Chen, An Hong
Summary: This study developed a novel low-molecular-weight peptide agonist CH02 targeting FGFR, which effectively promoted nerve regeneration, enhanced axon growth of sensory neurons, and robustly improved nerve regeneration and sensory-motor behavioral recovery in a rat spinal dorsal root injury model.
Review
Pharmacology & Pharmacy
Fritz Markwardt
Summary: Patch clamp investigations help understand the molecular function of single ion channels. The human P2X7 receptor is an ATP-gated ion channel involved in inflammatory and nociceptive reactions. Specific residues and domains play crucial roles in ion channel function.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Martini, Giorgio Rispoli
Summary: Some sensory disorders in hearing, vestibular, and vision can be attributed to voltage-gated Ca2+ channels in sensory cells. In this study, the Na+ current flowing through L- and R-type Ca2+ channels in labyrinth hair cells was investigated. The activation and deactivation of the Na+ current in L-type channels were affected by low Ca2+ concentration, resulting in increased current amplitude. The R-type Na+ current was partially blocked by nifedipine and its current amplitude increased in low Ca2+ condition. Furthermore, the selectivity filter of R channels was less affected by external Ca2+ compared to L channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Aseer Intisar, Seung Joon Lee, Yu-Gyeong Kim, Woon-Hae Kim, Hyun Young Shin, Min Young Kim, Jong Man Kim, Jungmin Lee, Yun Jeoung Mo, Yu Seon Kim, Seung-Hoon Kim, Yun-Il Lee, Minseok S. Kim
Summary: This study introduces a rapid method for enriching neurons from the mouse embryonic dorsal root ganglion using fully-automated continuous centrifugal microfluidics, achieving effective isolation within 13 minutes. The purified neurons showed improved viability and purity compared to conventional chemical purification methods, highlighting the potential of this automated system to advance neurological research.
Article
Cell Biology
Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu
Summary: The study reveals that Slack serves as a modulator of TRPA1-mediated activation of sensory neurons, but not TRPV1-mediated activation.
Article
Biochemistry & Molecular Biology
Karl Josef Foehr, Michael Rapp, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Summary: Aripiprazole has been identified as a potent blocker of the dominant voltage-gated sodium channel of heart muscle. Its interactions with the channel differ depending on the state, with weaker affinity for the resting state and stronger affinity for the inactivated state.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Ricardo H. Roda, David Bargiela, Weiran Chen, Ken Perry, Ronald J. Ellis, David B. Clifford, Ajay Bharti, Asha R. Kallianpur, Michelli F. Oliveira, Monica M. Diaz, Leah H. Rubin, Christina Gavegnano, Justin C. McArthur, Ahmet Hoke, Michael Polydefkis
Summary: The study aimed to evaluate the correlation of large mtDNA deletions in skin samples of people with HIV with measures of neuropathy and prior exposure to therapy. Results showed a correlation between the total mtDNA deletion and intraepidermal nerve fiber density (IENFD) and sural nerve amplitude in PWH with HIV-associated sensory neuropathy.
Article
Clinical Neurology
Jin-ru Zhang, Yu-lan Cao, Kai Li, Fen Wang, Ya-li Wang, Jia-jing Wu, Shao-fang Pei, Jing Chen, Cheng-jie Mao, Chun-feng Liu
Summary: The study found that in PD patients, those with thin baseline RNFL thickness performed worse in global cognitive tests, delayed memory, and executive functions, with more significant cognitive deterioration during follow-up. Lower baseline average RNFL thickness was associated with greater annualized decline in Mini-Mental State Examination and Montreal Cognitive Assessment.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Medicine, Research & Experimental
Yunmei Zhang, Yuan Zhang, Zizhang Wang, Yufang Sun, Xinghong Jiang, Man Xue, Yafeng Yu, Jin Tao
Summary: This study reveals that gentamicin decreases the I-DR in VG neurons through JNK and PKA-mediated signaling pathways, leading to neuronal hyperexcitability. Blocking JNK signaling and I-DR can attenuate this effect.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Geriatrics & Gerontology
Mei-Hong Lu, Wen-Li Ji, Hong Chen, Yan-Yun Sun, Xiu-Yun Zhao, Fen Wang, Yi Shi, Yan-Ning Hu, Bo-Xiang Liu, Jing-wen Wu, De-En Xu, Jia-Wei Zheng, Chun-Feng Liu, Quan-Hong Ma
Summary: The study demonstrated that intranasal delivery of human neural stem cells showed positive effects in Alzheimer's disease by improving pathological damages and rescuing cognitive function in transgenic mice.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chao Ren, Ling-Xi Li, An-Qi Dong, Yu-Ting Zhang, Hua Hu, Cheng-Jie Mao, Fen Wang, Chun-Feng Liu
Summary: The relationship between depression and Parkinson's disease is still not fully understood. This study suggests that depression may worsen dyskinesia and death of dopaminergic neurons in a PD model by promoting microglial activation and neuroinflammation mediated by P2X7R. Inhibition of P2X7R could be a new control strategy for PD associated with depression.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Chao Ren, Fen Wang, Kai-Jie He, Yu-Ting Zhang, Ling-Xi Li, Jin-Bao Zhang, Jing Chen, Cheng-Jie Mao, Chun-Feng Liu
Summary: Early-life stress can have long-term effects on human health, including the development of neurodegenerative diseases like Parkinson's disease. In this study, the researchers used a maternal separation model to explore the contribution of early-life stress to Parkinson's disease. They discovered behavioral, histochemical, neuromorphological, and transcriptional changes in rats that were separated from their mothers, providing new insights into the pathogenesis and potential therapies for Parkinson's disease related to depression.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Letter
Medicine, General & Internal
Yun Shen, Siyi Gong, Yulu Liu, Jie Li, Kangping Xiong, Chengjie Mao, Yali Wang, Dan Li, Fen Wang, Hua Hu, Chunfeng Liu
CHINESE MEDICAL JOURNAL
(2022)
Article
Neurosciences
Chao Ren, Kai-Jie He, Hua Hu, Jin-Bao Zhang, Li-Guo Dong, Dan Li, Jing Chen, Cheng-Jie Mao, Fen Wang, Chun-Feng Liu
Summary: This study found that knocking down astrocytic GLT-1 could lead to PD-like changes, including impaired motor function, abnormal gait, and depression-like features. Additionally, the dopaminergic system was impaired and the count of tyrosine hydroxylase (TH) positive neurons was reduced in astrocytic GLT-1 knockdown rats. Blocking glutamate excitotoxicity may provide a new strategy for the prevention and treatment of PD.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Multidisciplinary Sciences
Renfei Qi, Junping Cao, Yufang Sun, Yanping Li, Zitong Huang, Dongsheng Jiang, Xing-Hong Jiang, Terrance P. Snutch, Yuan Zhang, Jin Tao
Summary: In neuropathic pain, miR-32-5p plays a functional role by regulating Cav3.2 channels. Nerve injury-induced histone methylation decreases miR-32-5p expression, leading to increased Cav3.2 protein expression and pain-related behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
An-Qi Dong, Ya-Ping Yang, Shu-Min Jiang, Xiao-Yu Yao, Di Qi, Cheng-Jie Mao, Xiao-Yu Cheng, Fen Wang, Li-Fang Hu, Chun-Feng Liu
Summary: This study demonstrates the anti-neuroinflammatory activity of PPX through enhancing autophagy activity in astrocytes, which provides a new mechanism for the beneficial effect of PPX in Parkinson's disease therapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Ying Chen, Qing Yin, Xiao-Yu Cheng, Jin-Ru Zhang, Hong Jin, Kai Li, Cheng-Jie Mao, Fen Wang, Hong-Zhe Bei, Chun-Feng Liu
Summary: Induced pluripotent stem cells (iPSCs) can successfully mimic age-related diseases, such as Parkinson's disease (PD). In this study, we differentiated dopaminergic (DA) neurons from iPSCs of PD patients with the G2019S LRRK2 mutation and found morphological changes compared to control group. Furthermore, we observed that these mutated DA neurons were more vulnerable to damage, with higher rates of apoptosis and inflammatory response.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Liu
Summary: Pain in Parkinson's disease (PD) is a major factor affecting the life quality of PD patients. Traditional therapeutic drugs lacking efficacy on PD-related pain suggest the involvement of a mechanism outside the dopamine system. Previous studies have shown that decreased serotonin levels in the spinal dorsal horn (SDH) are associated with increased pain sensitivity in a 6-OHDA-induced PD model. In this study, we found that inhibition of spinal 5-HT3 receptors and reduction of SDH neuronal excitability can alleviate hyperalgesia in PD rats. These findings provide a novel mechanism and potential therapeutic strategy for pain management in PD patients.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Qian-Kun Lv, Kang-Xin Tao, Xiao-Bo Wang, Xiao-Yu Yao, Meng-Zhu Pang, Jun-Yi Liu, Fen Wang, Chun-Feng Liu
Summary: Parkinson's disease is a common neurodegenerative disease characterized by the accumulation of alpha-synuclein in microglia, leading to neuroinflammation. The autophagy and phagocytosis functions of microglia are related to the clearance of alpha-synuclein and the inhibition of neuroinflammation. This review discusses the interaction between microglia and alpha-synuclein in Parkinson's disease pathogenesis, and the possible mechanisms of microglial autophagy and phagocytosis in the clearance of alpha-synuclein and inhibition of neuroinflammation.
INFLAMMATION RESEARCH
(2023)
Article
Neurosciences
Jun-Yi Liu, Jian Xue, Fen Wang, Ya-Li Wang, Wan-Li Dong
Summary: Circadian dysfunction is a common non-motor symptom in Parkinson's disease. The potential influence of SNCA on circadian disruption remains unclear. This study showed that overexpression of SNCA induced biorhythm disruption and downregulated BMAL1 expression through decreasing stability of BMAL1 mRNA via miR-155.
NEUROTOXICITY RESEARCH
(2023)
Article
Oncology
Zhong-Ming Ying, Qian-Kun Lv, Xiao-Yu Yao, An-Qi Dong, Ya-Ping Yang, Yu-Lan Cao, Fen Wang, Ai-Ping Gong, Chun-Feng Liu
Summary: This study demonstrates that BAG3 promotes autophagy and suppresses the formation of NLRP3 inflammasome in Parkinson's disease.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Yi-Lun Ge, Si-Yi Gong, Pu-Zhi Wang, Jia-Hui Yan, Wen Li, Jin-Ru Zhang, Hong Jin, Sheng Zhuang, Lei Hu, Chang-Wei Ding, Ya-Ping Yang, Fen Wang, Dan Li, Jing Chen, Cheng-Jie Mao, Ying-Chun Zhang, Kai Li, Chun-Feng Liu
Summary: This study aimed to assess the association between cerebrovascular function and cognitive performance in patients with Parkinson's disease (PD). The results showed that cerebrovascular function was significantly associated with cognitive performance, especially in the memory task. A model combining clinical and hemodynamic variables was effective in identifying cognitive impairment in PD patients, which could be a useful tool for early screening of cognitive decline. Further studies with larger sample sizes in different populations are needed.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)