E3 ubiquitin ligase RNF180 impairs IPO4/SOX2 complex stability and inhibits SOX2-mediated malignancy in ovarian cancer

RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination

(2023) Qirui Zhao et al.   CELL CYCLE

E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1

(2023) Nannan Zhang et al.   Clinical Epigenetics

E3 ubiquitin ligase RNF180 reduces sensitivity of triple-negative breast cancer cells to Gefitinib by downregulating RAD51

(2022) Pian Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Ubiquitin ligases: guardians of mammalian development

(2022) David A. Cruz Walma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Correction: Ring finger protein 180 suppresses cell proliferation and energy metabolism of non-small cell lung cancer through downregulating C-myc

(2022) Yi Ding et al.   World Journal of Surgical Oncology

Knocking down of Polo-like kinase 2 inhibits cell proliferation and induced cell apoptosis in human glioma cells

(2021) Fang Cao et al.   LIFE SCIENCES

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

(2021) Bikshapathi Jagga et al.   Nature Communications

Characterization of SOX2, OCT4 and NANOG in Ovarian Cancer Tumor-Initiating Cells

(2021) Mikella Robinson et al.   Cancers

DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells

(2021) Weilin Sun et al.   Cell Death & Disease

Ovarian Cancer Screening: Current status and future directions

(2020) Zachary Nash et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Karyopherins and condensates

(2020) Charis E. Springhower et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer

(2020) Yang Zhou et al.   ONCOGENE

RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells

(2020) Zizhen Wu et al.   Cell Death & Disease

Importin-4 functions as a driving force in human primary gastric cancer

(2019) Xia Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SOX2 in development and cancer biology

(2019) Daniel Novak et al.   SEMINARS IN CANCER BIOLOGY

p21 in Cancer Research

(2019) Shamloo et al.   Cancers

Epidemiology and treatment patterns of epithelial ovarian cancer

(2017) Philip Jessmon et al.   Expert Review of Anticancer Therapy

Clinical and experimental role of ring finger protein 180 on lymph node metastasis and survival in gastric cancer

(2016) J. Deng et al.   BRITISH JOURNAL OF SURGERY

Importins and exportins as therapeutic targets in cancer

(2016) Amit Mahipal et al.   PHARMACOLOGY & THERAPEUTICS

Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner

(2015) Min Shi et al.   Cell Discovery

Cell-Cycle Protein Expression in a Population-Based Study of Ovarian and Endometrial Cancers

(2015) Ashley S. Felix et al.   Frontiers in Oncology

Macromolecular transport between the nucleus and the cytoplasm: Advances in mechanism and emerging links to disease

(2014) Elizabeth J. Tran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation

(2014) Elizabeth Lokich et al.   Scientific Reports

The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients

(2013) Yefei Huang et al.   JOURNAL OF GASTROENTEROLOGY

Rines E3 Ubiquitin Ligase Regulates MAO-A Levels and Emotional Responses

(2013) M. Kabayama et al.   JOURNAL OF NEUROSCIENCE

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

(2013) M Herreros-Villanueva et al.   Oncogenesis

Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

(2012) M. Ángeles Marqués-Torrejón et al.   Cell Stem Cell

Characterization of the gene structure, functional significance, and clinical application ofRNF180, a novel gene in gastric cancer

(2011) Kin-Fai Cheung et al.   CANCER

Expression of Sox2 in human ovarian epithelial carcinoma

(2010) Feng Ye et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

(2010) Roelof Koster et al.   JOURNAL OF CLINICAL INVESTIGATION

CCAAT/enhancer binding protein delta (C/EBP , CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of hypoxia-inducible factor HIF-1α into the nucleus involves importins 4 and 7

(2009) Georgia Chachami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ring Finger Ubiquitin Protein Ligases and Their Implication to the Pathogenesis of Human Diseases

(2009) Helen Ardley   CURRENT PHARMACEUTICAL DESIGN

Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors

(2009) Cristina Gontan et al.   JOURNAL OF CELL BIOLOGY

Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase

(2008) Miyuki Ogawa et al.   GENES TO CELLS