Induction of Parkinsonian-Like Changes via Targeted Downregulation of Astrocytic Glutamate Transporter GLT-1 in the Striatum

Depression Induced by Chronic Unpredictable Mild Stress Increases Susceptibility to Parkinson’s Disease in Mice via Neuroinflammation Mediated by P2X7 Receptor

(2021) Chao Ren et al.   ACS Chemical Neuroscience

Downregulation of astroglial glutamate transporter GLT-1 in the lateral habenula is associated with depressive-like behaviors in a rat model of Parkinson's disease

(2021) Shuxuan Lyu et al.   NEUROPHARMACOLOGY

Generation of a Novel Mouse Model of Parkinson’s Disease via Targeted Knockdown of Glutamate Transporter GLT-1 in the Substantia Nigra

(2020) Yunlong Zhang et al.   ACS Chemical Neuroscience

The interplay between depression and Parkinson´s disease: learning the link through Ca2+/cAMP signalling

(2020) Leandro Bueno Bergantin   CURRENT PROTEIN & PEPTIDE SCIENCE

BMAL1 regulation of microglia‐mediated neuroinflammation in MPTP‐induced Parkinson's disease mouse model

(2020) Wen‐Wen Liu et al.   FASEB JOURNAL

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease

(2020) Irena Smaga et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice

(2020) Yun-Fang Jia et al.   Frontiers in Behavioral Neuroscience

The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases

(2020) Alison C. Todd et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems

(2019) Yu Xu et al.   Neuroscience Bulletin

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

(2019) Edward Pajarillo et al.   NEUROPHARMACOLOGY

Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson’s Disease

(2019) Xiaojuan Wu et al.   ACS Chemical Neuroscience

Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway

(2019) Shaogang Qu et al.   Aging-US

Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target

(2019) Allison R. Peterson et al.   Frontiers in Molecular Neuroscience

Roles of Glutamate Receptors in Parkinson’s Disease

(2019) Zhu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

(2019) Shirley Yin-Yu Pang et al.   Translational Neurodegeneration

A compendious summary of Parkinson’s disease patient-derived iPSCs in the first decade

(2019) Chao Ren et al.   Annals of Translational Medicine

Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior

(2019) Neus Fullana et al.   NEUROPHARMACOLOGY

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites

(2018) Changliang Liu et al.   CELL

zolpidem ameliorates motor impairments in the unilaterally 6-hydroxydopamine-lesioned rat

(2018) Robert Assini et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Olfactory Dysfunction in Autoimmune Central Nervous System Neuroinflammation

(2018) Jeongtae Kim et al.   MOLECULAR NEUROBIOLOGY

Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice

(2018) James Johnson et al.   NEUROTOXICOLOGY

Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity

(2018) James Johnson et al.   NEUROTOXICOLOGY

The effects of ketamine on sexual behavior, anxiety, and locomotion in female rats

(2018) Fay A. Guarraci et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Dopamine neuron activity before action initiation gates and invigorates future movements

(2018) Joaquim Alves da Silva et al.   NATURE

Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson’s disease

(2017) Chen-Tao Wang et al.   Molecular Pain

Ceftriaxone reduces L -dopa-induced dyskinesia severity in 6-hydroxydopamine parkinson's disease model

(2017) Tanya Chotibut et al.   MOVEMENT DISORDERS

Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease: An update from the last 5 years of research

(2017) Nadhir Litim et al.   NEUROPHARMACOLOGY

Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model

(2017) Yunlong Zhang et al.   Cell Death & Disease

Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease

(2017) Yunlong Zhang et al.   Cell Death & Disease

GLT-1: The elusive presynaptic glutamate transporter

(2016) Theresa S. Rimmele et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocytes gate Hebbian synaptic plasticity in the striatum

(2016) Silvana Valtcheva et al.   Nature Communications

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression

(2016) Jin-Mo Kim et al.   Scientific Reports

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

(2015) Anders A Jensen et al.   CURRENT OPINION IN PHARMACOLOGY

Targeting glutamatergic synapses in Parkinson's disease

(2015) Fabrizio Gardoni et al.   CURRENT OPINION IN PHARMACOLOGY

Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson's disease dementia

(2015) Chao-Yu Hsu et al.   NEUROPHARMACOLOGY

Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release

(2015) Seungwon Choi et al.   PLoS Genetics

Ipsilateral Hippocampal Proteomics Reveals Mitochondrial Antioxidative Stress Impairment in Cortical-Lesioned Chronic Mild Stressed Rats

(2014) J. Pan et al.   CURRENT MOLECULAR MEDICINE

EAAT2 (GLT-1; slc1a2) Glutamate Transporters Reconstituted in Liposomes Argues against Heteroexchange Being Substantially Faster than Net Uptake

(2014) Y. Zhou et al.   JOURNAL OF NEUROSCIENCE

Ceftriaxone Protects Astrocytes from MPP+ via Suppression of NF-κB/JNK/c-Jun Signaling

(2014) Yunlong Zhang et al.   MOLECULAR NEUROBIOLOGY

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

(2014) Maxime Assous et al.   NEUROBIOLOGY OF DISEASE

GLT-1 transporter: An effective pharmacological target for various neurological disorders

(2014) Neha Soni et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antidepressant-like activity of turmerone in behavioral despair tests in mice

(2013) Jung-Chun Liao et al.   BMC Complementary and Alternative Medicine

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

(2013) Giulia Ambrosi et al.   JOURNAL OF NEURAL TRANSMISSION

Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model

(2013) Tanya Chotibut et al.   MOLECULAR NEUROBIOLOGY

The effects of astrocytes on differentiation of neural stem cells are influenced by knock-down of the glutamate transporter, GLT-1

(2013) Yijing Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation

(2013) F. Cotel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser19

(2012) Michael F. Salvatore et al.   EXPERIMENTAL NEUROLOGY

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

Ceftriaxone Ameliorates Motor Deficits and Protects Dopaminergic Neurons in 6-Hydroxydopamine-Lesioned Rats

(2011) T. C. H. Leung et al.   ACS Chemical Neuroscience

Time-dependent changes in GLT-1 functioning in striatum of hemi-Parkinson rats

(2010) Ann Massie et al.   NEUROCHEMISTRY INTERNATIONAL

Enhancement of glutamate uptake in 1-methyl-4-phenylpyridinium-treated astrocytes by trichostatin A

(2009) Jia-Yong Wu et al.   NEUROREPORT

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats

(2008) E.K.Y. Chung et al.   JOURNAL OF COMPARATIVE NEUROLOGY