4.3 Article

Proteases in bacterial pathogenesis

Journal

RESEARCH IN MICROBIOLOGY
Volume 160, Issue 9, Pages 704-710

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2009.08.017

Keywords

Virulence regulators; Pathogenesis; Lon; Clp; HtrA and FtsH proteases; Type III secretion; Quorum sensing

Categories

Funding

  1. European Union [036272]
  2. The Danish Research Council for Natural Sciences

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Bacterial pathogens rely on proteolysis for protein quality control under adverse conditions experienced in the host, as well as for the timely degradation of central virulence regulators. We have focused on the contribution of the conserved Lon, Clp, HtrA and FtsH proteases to pathogenesis and have highlighted common biological processes for which their activities are important for virulence. (C) 2009 Elsevier Masson SAS. All rights reserved.

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