Critical role of mitosis in spontaneous late-onset Alzheimer’s disease; from a Shugoshin 1 cohesinopathy mouse model

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

(2018) Shireen Chikara et al.   CANCER LETTERS

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

(2018) Sofia Söllvander et al.   Journal of Neuroinflammation

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Review: Somatic mutations in neurodegeneration

(2018) M. Leija-Salazar et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

(2018) Willemijn J. Jansen et al.   JAMA Psychiatry

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”

(2017) John Hardy   FEBS Journal

Characterization of Sgo1 expression in developing and adult mouse

(2017) Andrew T. Song et al.   GENE EXPRESSION PATTERNS

Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Aging and Alzheimer’s Disease

(2017) Jorge Valero et al.   JOURNAL OF ALZHEIMERS DISEASE

Potential oxidative stress biomarkers of mild cognitive impairment due to Alzheimer disease

(2017) Ana García-Blanco et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

(2017) Giovanni B Frisoni et al.   LANCET NEUROLOGY

Genome instability in Alzheimer disease

(2017) Yujun Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease

(2017) K. E. Ameen-Ali et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

Perspective Insights into Disease Progression, Diagnostics, and Therapeutic Approaches in Alzheimer's Disease: A Judicious Update

(2017) Arif Tasleem Jan et al.   Frontiers in Aging Neuroscience

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins

(2017) Jesús Avila et al.   Frontiers in Neuroscience

The progeroid gene BubR1 regulates axon myelination and motor function

(2016) Chan-Il Choi et al.   Aging-US

Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice

(2016) C. V. Rao et al.   CANCER RESEARCH

Investigating somatic aneuploidy in the brain: why we need a new model

(2016) Jimi L. Rosenkrantz et al.   CHROMOSOMA

Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia

(2016) Jennifer Y.Y. Szeto et al.   Current Neuropharmacology

Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression

(2016) Laura C. Funk et al.   DEVELOPMENTAL CELL

Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease

(2016) Shi Shi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Non human primate models for Alzheimer’s disease-related research and drug discovery

(2016) Debby Van Dam et al.   Expert Opinion on Drug Discovery

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation

(2016) Lauren M. Zasadil et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging links among Chromosome Instability (CIN), cancer, and aging

(2016) Chinthalapally V. Rao et al.   MOLECULAR CARCINOGENESIS

Treating cancer with selective CDK4/6 inhibitors

(2016) Ben O'Leary et al.   Nature Reviews Clinical Oncology

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß 1-42 oligomers in mice

(2016) Gian Marco Leggio et al.   PHARMACOLOGICAL RESEARCH

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

(2016) Veronika Logovinsky et al.   Alzheimers Research & Therapy

Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung

(2016) H Y Yamada et al.   Oncogenesis

Metabolic profiling distinguishes three subtypes of Alzheimer's disease

(2015) Dale E. Bredesen   Aging-US

Down syndrome and Alzheimer's disease: Common pathways, common goals

(2015) Dean Hartley et al.   Alzheimers & Dementia

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice

(2015) Hiroshi Y. Yamada et al.   CARCINOGENESIS

Aneuploidy-induced cellular stresses limit autophagic degradation

(2015) Stefano Santaguida et al.   GENES & DEVELOPMENT

IncreasedSTAG2dosage defines a novel cohesinopathy with intellectual disability and behavioral problems

(2015) Raman Kumar et al.   HUMAN MOLECULAR GENETICS

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia

(2015) Joshua F. Zeidner et al.   LEUKEMIA RESEARCH

Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model

(2015) Chinthalapally V. Rao et al.   MOLECULAR CARCINOGENESIS

Genome instability biomarkers and blood micronutrient risk profiles associated with mild cognitive impairment and Alzheimer's disease

(2015) Sau Lai Lee et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Alzheimer disease market

(2015) XiaoXiao Qian et al.   NATURE REVIEWS DRUG DISCOVERY

Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability

(2015) Vladan Bajic et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

BubR1 kinase: protection against aneuploidy and premature aging

(2015) Maria Kapanidou et al.   TRENDS IN MOLECULAR MEDICINE

Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

(2015) Xinzhong Li et al.   Scientific Reports

The centrosome duplication cycle in health and disease

(2014) Erich A. Nigg et al.   FEBS LETTERS

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

(2014) Philippe Chetaille et al.   NATURE GENETICS

Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study

(2014) Chin-Chou Huang et al.   PLoS One

Cell Proliferation and Neurogenesis in Adult Mouse Brain

(2014) Olivia L. Bordiuk et al.   PLoS One

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

A review of β-amyloid neuroimaging in Alzheimer's disease

(2014) Paul A. Adlard et al.   Frontiers in Neuroscience

Mitosis as an anti-cancer drug target

(2013) Anna-Leena Salmela et al.   CHROMOSOMA

Frameshift mutations of chromosome cohesion–related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability

(2013) Min Sung Kim et al.   HUMAN PATHOLOGY

Amyloid-  signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

(2013) M. E. Seward et al.   JOURNAL OF CELL SCIENCE

NIH gambles on recycled drugs

(2013) Meredith Wadman   NATURE

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers

(2013) Shun Matsuura et al.   Scientific Reports

Haploinsufficiency ofSGO1results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis

(2012) Hiroshi Y. Yamada et al.   CELL CYCLE

Mitosis-Targeting Natural Products for Cancer Prevention and Therapy

(2012) Chinthalapally V. Rao et al.   CURRENT DRUG TARGETS

Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

(2012) Masashi Kitazawa et al.   CURRENT PHARMACEUTICAL DESIGN

The Micron Stroke Hypothesis of Alzheimer’s Disease and Dementia

(2012) Allen J. Orehek   MEDICAL HYPOTHESES

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

(2011) Monique Judge et al.   Molecular Neurodegeneration

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Cleavage of cohesin rings coordinates the separation of centrioles and chromatids

(2011) Laura Schöckel et al.   NATURE CELL BIOLOGY

Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death

(2011) Jaume Folch et al.   NEUROTOXICITY RESEARCH

A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion

(2011) T Kahyo et al.   ONCOGENE

Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

(2010) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Premature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Age

(2010) L. Zivkovic et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice

(2009) C. V. Rao et al.   CARCINOGENESIS

The role of aneuploidy in promoting and suppressing tumors: Figure 1.

(2009) Beth A.A. Weaver et al.   JOURNAL OF CELL BIOLOGY

Neural cell cycle dysregulation and central nervous system diseases

(2009) Wei Wang et al.   PROGRESS IN NEUROBIOLOGY

sSgo1, a Major Splice Variant of Sgo1, Functions in Centriole Cohesion Where It Is Regulated by Plk1

(2008) Xiaoxing Wang et al.   DEVELOPMENTAL CELL

sSgo1, a Guardian of Centriole Cohesion

(2008) William Y. Tsang et al.   DEVELOPMENTAL CELL

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer

(2008) M Iwaizumi et al.   GUT

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Whole chromosome instability and cancer: a complex relationship

(2008) Robin M. Ricke et al.   TRENDS IN GENETICS

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES

Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

(2007) T. Boveri   JOURNAL OF CELL SCIENCE