Investigating somatic aneuploidy in the brain: why we need a new model

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

(2017) Grasiella A. Andriani et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

(2016) Vadim N. Gladyshev   AGING CELL

A comprehensive transcriptional map of primate brain development

(2016) Trygve E. Bakken et al.   NATURE

Single-cell genome sequencing: current state of the science

(2016) Charles Gawad et al.   NATURE REVIEWS GENETICS

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Interactive analysis and assessment of single-cell copy-number variations

(2015) Tyler Garvin et al.   NATURE METHODS

Mammalian pre-implantation chromosomal instability: species comparison, evolutionary considerations, and pathological correlations

(2015) Lucia Carbone et al.   Systems Biology in Reproductive Medicine

Quantitative assessment of single-cell whole genome amplification methods for detecting copy number variation using hippocampal neurons

(2015) Luwen Ning et al.   Scientific Reports

SNES: single nucleus exome sequencing

(2015) Marco L Leung et al.   GENOME BIOLOGY

Modeling genome coverage in single-cell sequencing

(2014) Timothy Daley et al.   BIOINFORMATICS

Basic Neuroscience Research with Nonhuman Primates: A Small but Indispensable Component of Biomedical Research

(2014) Pieter R. Roelfsema et al.   NEURON

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

(2014) Xuyu Cai et al.   Cell Reports

Progress and Prospects for Genetic Modification of Nonhuman Primate Models in Biomedical Research

(2013) A. W. S. Chan   ILAR JOURNAL

Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells

(2013) Jeff Gole et al.   NATURE BIOTECHNOLOGY

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Mosaic Copy Number Variation in Human Neurons

(2013) M. J. McConnell et al.   SCIENCE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Somatic Mutation, Genomic Variation, and Neurological Disease

(2013) A. Poduri et al.   SCIENCE

The genomically mosaic brain: Aneuploidy and more in neural diversity and disease

(2013) Diane M. Bushman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Changes in neuronal DNA content variation in the human brain during aging

(2012) Hans-Georg Fischer et al.   AGING CELL

Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain

(2012) Gilad D. Evrony et al.   CELL

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

(2012) Francesca Faggioli et al.   HUMAN MOLECULAR GENETICS

Aneuploid Cells Are Differentially Susceptible to Caspase-Mediated Death during Embryonic Cerebral Cortical Development

(2012) S. E. Peterson et al.   JOURNAL OF NEUROSCIENCE

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Genome-wide copy number analysis of single cells

(2012) Timour Baslan et al.   Nature Protocols

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension

(2012) A. Kolano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell

(2012) C. Zong et al.   SCIENCE

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

(2012) Shawn L. Chavez et al.   Nature Communications

Looking for differences in copy number between blood and brain in sporadic amyotrophic lateral sclerosis

(2011) Roger Pamphlett et al.   MUSCLE & NERVE

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis

(2011) Catarina P. Samora et al.   NATURE CELL BIOLOGY

High-throughput microfluidic single-cell RT-qPCR

(2011) A. K. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

(2010) Thomas Arendt et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Neuronal DNA content variation (DCV) with regional and individual differences in the human brain

(2010) Jurjen W. Westra et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?

(2010) Tatjana Singer et al.   TRENDS IN NEUROSCIENCES

The Chromosomal Constitution of Postmitotic Neurons, Assessed by Neuronal Nuclear Transfer into Oocytes and in ES Cell Lines Derived from Them

(2009) T. Osada et al.   CYTOGENETIC AND GENOME RESEARCH

Evolution of the neocortex: a perspective from developmental biology

(2009) Pasko Rakic   NATURE REVIEWS NEUROSCIENCE

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning

(2009) Ivan Y. Iourov et al.   NEUROBIOLOGY OF DISEASE

Aneuploid mosaicism in the developing and adult cerebellar cortex

(2008) Jurjen W. Westra et al.   JOURNAL OF COMPARATIVE NEUROLOGY