Regulation and roles of Cdc7 kinase under replication stress

Regulation of chromosome dynamics by Hsk1/Cdc7 kinase

(2015) Seiji Matsumoto et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Controlling ARF stability

(2014) Omid Tavana et al.   CELL CYCLE

MKK7 and ARF

(2014) Athanassios Kotsinas et al.   CELL CYCLE

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

(2014) S.-i. Hiraga et al.   GENES & DEVELOPMENT

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

(2014) W. T. Poh et al.   Open Biology

Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer

(2013) R. Fagerholm et al.   ANNALS OF ONCOLOGY

Dbf4: The whole is greater than the sum of its parts

(2013) Lindsay Matthews et al.   CELL CYCLE

INK4a/ARF limits the expansion of cells suffering from replication stress

(2013) Angela Monasor et al.   CELL CYCLE

Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint

(2013) Michael Rainey et al.   CELL CYCLE

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

(2013) K Evangelou et al.   CELL DEATH AND DIFFERENTIATION

ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

(2013) M. Yamada et al.   GENES & DEVELOPMENT

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks

(2013) Michael Durando et al.   NUCLEIC ACIDS RESEARCH

Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing

(2013) Satoshi Yamazaki et al.   TRENDS IN GENETICS

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

(2013) Alessandro Natoni et al.   Cancers

Aminopyrimidinone Cdc7 Kinase Inhibitors

(2012) Keith W. Woods et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of XL413, a potent and selective CDC7 inhibitor

(2012) Elena S. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo

(2012) Sylvia Takacova et al.   CANCER CELL

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment

(2012) Lenka Oplustilova et al.   CELL CYCLE

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

(2012) Daniela Cornacchia et al.   EMBO JOURNAL

Rif1 regulates the replication timing domains on the human genome

(2012) Satoshi Yamazaki et al.   EMBO JOURNAL

Rif1 is a global regulator of timing of replication origin firing in fission yeast

(2012) M. Hayano et al.   GENES & DEVELOPMENT

Degradation of Human RAP80 is Cell Cycle Regulated by Cdc20 and Cdh1 Ubiquitin Ligases

(2012) H. J. Cho et al.   MOLECULAR CANCER RESEARCH

Thresholds of replication stress signaling in cancer development and treatment

(2012) Jiri Bartek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI

(2011) S. A. Williams et al.   BLOOD

Integrating DNA replication with trans-lesion synthesis via Cdc7 

(2011) Cyrus Vaziri et al.   CELL CYCLE

Synthetic lethality of PARP inhibition in cancers lackingBRCA1andBRCA2mutations

(2011) Konstantin J. Dedes et al.   CELL CYCLE

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint

(2011) Alan Yueh-Luen Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells

(2011) A. Natoni et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

(2011) George-Lucian Moldovan et al.   MOLECULAR CELL

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

(2011) Koji Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication

(2010) Tovah A. Day et al.   JOURNAL OF CELL BIOLOGY

Srs2 Plays a Critical Role in Reversible G2 Arrest upon Chronic and Low Doses of UV Irradiation via Two Distinct Homologous Recombination-Dependent Mechanisms in Postreplication Repair-Deficient Cells

(2010) T. Hishida et al.   MOLECULAR AND CELLULAR BIOLOGY

Damage-induced phosphorylation of Sld3 is important to block late origin firing

(2010) Jaime Lopez-Mosqueda et al.   NATURE

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

(2010) Philip Zegerman et al.   NATURE

Cdc7 kinase – A new target for drug development

(2009) Ronan Swords et al.   EUROPEAN JOURNAL OF CANCER

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

(2009) Kasper Fugger et al.   JOURNAL OF CELL BIOLOGY

Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

(2009) J. K. Hicks et al.   MOLECULAR AND CELLULAR BIOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

(2008) Florian Bassermann et al.   CELL

Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships

(2008) Ermes Vanotti et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control

(2008) Toshiya Tsuji et al.   MOLECULAR CELL

RAD6–RAD18–RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

(2008) Takashi Hishida et al.   NATURE

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

(2008) Alessia Montagnoli et al.   Nature Chemical Biology

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE