MKK7 and ARF

Controlling ARF stability

(2014) Omid Tavana et al.   CELL CYCLE

INK4a/ARF limits the expansion of cells suffering from replication stress

(2013) Angela Monasor et al.   CELL CYCLE

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

(2013) K Evangelou et al.   CELL DEATH AND DIFFERENTIATION

Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression

(2013) Delin Chen et al.   MOLECULAR CELL

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

ARF induction in response to DNA strand breaks is regulated by PARP1

(2013) Giulia Orlando et al.   NUCLEIC ACIDS RESEARCH

Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

(2013) Koralia E. Paschalaki et al.   STEM CELLS

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

(2013) Ana Rita Carlos et al.   Nature Communications

Aging, Atherosclerosis, and IGF-1

(2012) Y. Higashi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Insulin-like growth factor-1 receptor activation prevents hydrogen peroxide-induced oxidative stress, mitochondrial dysfunction and apoptosis

(2011) Chang-Ning Hao et al.   APOPTOSIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

(2011) Maria Sideridou et al.   JOURNAL OF CELL BIOLOGY

New insights into oncogenic stress

(2011) Kevin M Haigis et al.   NATURE GENETICS

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

(2011) Daniel Schramek et al.   NATURE GENETICS

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

WIP1 phosphatase at the crossroads of cancer and aging

(2009) Xavier Le Guezennec et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tied Up in Loops: Positive and Negative Autoregulation of p53

(2009) X. Lu   Cold Spring Harbor Perspectives in Biology

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Novel ATM-Dependent Pathway Regulates Protein Phosphatase 1 in Response to DNA Damage

(2008) X. Tang et al.   MOLECULAR AND CELLULAR BIOLOGY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE