Fasting levels of hepatic p-S6 are increased in old mice

Growth and aging: a common molecular mechanism

(2016) Mikhail V. Blagosklonny et al.   Aging-US

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

(2016) Olga V. Leontieva et al.   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Will calorie restriction work in humans?

(2016) Edda Cava et al.   Aging-US

Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

(2016) Sahar Emran et al.   Aging-US

Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

(2014) Olga V. Leontieva et al.   AGING CELL

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin

(2014) Irina G Popovich et al.   CANCER BIOLOGY & THERAPY

M(o)TOR of pseudo-hypoxic state in aging: Rapamycin to the rescue

(2014) Olga V. Leontieva et al.   CELL CYCLE

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

(2014) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium

(2014) O V Leontieva et al.   Cell Death & Disease

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion

(2013) Olga V. Leontieva et al.   CELL CYCLE

MEK drives cyclin D1 hyperelevation during geroconversion

(2013) O V Leontieva et al.   CELL DEATH AND DIFFERENTIATION

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Prospective Treatment of Age-Related Diseases by Slowing Down Aging

(2012) Mikhail V. Blagosklonny   AMERICAN JOURNAL OF PATHOLOGY

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Dissecting the role of mTOR complexes in cellular senescence

(2012) Manuel Serrano   CELL CYCLE

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice

(2012) Colin Selman et al.   CELL CYCLE

Rapamycin slows aging in mice

(2012) Adam Spong et al.   CELL CYCLE

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

(2012) Marina Kolesnichenko et al.   CELL CYCLE

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

(2012) Cecilia A. Hinojosa et al.   EXPERIMENTAL GERONTOLOGY

Status of mTOR activity may phenotypically differentiate senescence and quiescence

(2012) Sohee Cho et al.   MOLECULES AND CELLS

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

(2012) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

(2011) Evi M. Mercken et al.   AGEING RESEARCH REVIEWS

TOR-driven aging: Speeding car without brakes

(2011) Mikhail V Blagosklonny   CELL CYCLE

Aging-suppressants: Cellular senescence (hyperactivation) and its pharmacologic deceleration

(2011) Mikhail V Blagosklonny   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Hot topics in aging research: protein translation and TOR signaling, 2010

(2010) Matt Kaeberlein et al.   AGING CELL

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A midlife longevity drug?

(2009) Matt Kaeberlein et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling