p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response

The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication

(2011) Alexandra Deichsel et al.   CELL CYCLE

Chromatin dynamics and the repair of DNA double strand breaks

(2011) Ye Xu et al.   CELL CYCLE

VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion

(2011) Go Totsukawa et al.   EMBO JOURNAL

Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy

(2011) Kristijan Ramadan et al.   FEBS LETTERS

Destroying the ring: Freeing DNA from Ku with ubiquitin

(2011) Lisa Postow   FEBS LETTERS

Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses

(2011) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells

(2011) G. Dobrynin et al.   JOURNAL OF CELL SCIENCE

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

(2011) Malavika Raman et al.   MOLECULAR CELL

CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication

(2011) André Franz et al.   MOLECULAR CELL

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

(2011) Mayura Meerang et al.   NATURE CELL BIOLOGY

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

p97/VCP at the intersection of the autophagy and the ubiquitin proteasome system

(2010) Jeong-Sun Ju et al.   Autophagy

Loss of 53BP1 Is a Gain for BRCA1 Mutant Cells

(2010) Elizabeth M. Kass et al.   CANCER CELL

HERC2 Is an E3 Ligase That Targets BRCA1 for Degradation

(2010) W. Wu et al.   CANCER RESEARCH

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Solving the RIDDLE of 53BP1 recruitment to sites of damage

(2010) Grant S. Stewart   CELL CYCLE

The ubiquitous role of ubiquitin in the DNA damage response

(2010) Abdallah Al-Hakim et al.   DNA REPAIR

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

(2009) Yusuke Sato et al.   EMBO JOURNAL

Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein

(2009) Yukio Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor–promoter DNA complex

(2009) Alexander J. Wilcox et al.   NATURE CELL BIOLOGY

Crosstalk between histone modifications during the DNA damage response

(2009) Haico van Attikum et al.   TRENDS IN CELL BIOLOGY

Role(s) of Cdc48/p97 in mitosis

(2008) Hemmo Meyer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

Ku80 removal from DNA through double strand break–induced ubiquitylation

(2008) Lisa Postow et al.   JOURNAL OF CELL BIOLOGY

GTPase-Mediated Regulation of the Unfolded Protein Response in Caenorhabditis elegans Is Dependent on the AAA+ ATPase CDC-48

(2008) M.-E. Caruso et al.   MOLECULAR AND CELLULAR BIOLOGY