Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy

DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

(2011) Sajjad Hussain et al.   CELL CYCLE

Turnover of BRCA1 Involves in Radiation-Induced Apoptosis

(2011) Weijun Liu et al.   PLoS One

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

(2011) R. G. Hibbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome inhibitors in cancer therapy

(2011) Lisa J. Crawford et al.   Journal of Cell Communication and Signaling

HERC2 Is an E3 Ligase That Targets BRCA1 for Degradation

(2010) W. Wu et al.   CANCER RESEARCH

Coping with DNA double strand breaks

(2010) Kevin Hiom   DNA REPAIR

The ubiquitous role of ubiquitin in the DNA damage response

(2010) Abdallah Al-Hakim et al.   DNA REPAIR

RNAi-based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells

(2010) Wojciech Piwko et al.   EMBO JOURNAL

The interface between the ubiquitin family and the DNA damage response

(2010) Jiri Lukas   EMBO REPORTS

The MMS22L-TONSL Complex Mediates Recovery from Replication Stress and Homologous Recombination

(2010) Lara O'Donnell et al.   MOLECULAR CELL

Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination

(2010) Eris Duro et al.   MOLECULAR CELL

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

(2010) Brenda C. O'Connell et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA resection in eukaryotes: deciding how to fix the break

(2010) Pablo Huertas   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Proteasomal Degradation of Rpn4 Impairs Nonhomologous End-Joining Repair of DNA Double-Strand Breaks

(2010) Donghong Ju et al.   PLoS One

Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair

(2010) Shay Ben-Aroya et al.   PLoS Genetics

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Mechanisms of double-strand break repair in somatic mammalian cells

(2009) Andrea J. Hartlerode et al.   BIOCHEMICAL JOURNAL

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

Targeting the DNA Damage Response in Cancer

(2009) Mats Ljungman   CHEMICAL REVIEWS

Regulatory ubiquitylation in response to DNA double-strand breaks

(2009) Stephanie Panier et al.   DNA REPAIR

Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks

(2009) Chao-Po Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

(2009) Jurgen A. Marteijn et al.   JOURNAL OF CELL BIOLOGY

The ubiquitin landscape at DNA double-strand breaks

(2009) Troy E. Messick et al.   JOURNAL OF CELL BIOLOGY

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

(2009) Simon Bekker-Jensen et al.   NATURE CELL BIOLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin linkages make a difference

(2009) Ivan Dikic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

(2009) M. Harreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between histone modifications during the DNA damage response

(2009) Haico van Attikum et al.   TRENDS IN CELL BIOLOGY

Mammalian 26S Proteasomes Remain Intact during Protein Degradation

(2008) Franziska Kriegenburg et al.   CELL

Mechanisms of Dealing with DNA Damage-Induced Replication Problems

(2008) Magda Budzowska et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Control of DNA polymerase λ stability by phosphorylation and ubiquitination during the cell cycle

(2008) Ursula Wimmer et al.   EMBO REPORTS

Disassembly of MDC1 Foci Is Controlled by Ubiquitin-Proteasome-dependent Degradation

(2008) Wei Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ku80 removal from DNA through double strand break–induced ubiquitylation

(2008) Lisa Postow et al.   JOURNAL OF CELL BIOLOGY

The Anaphase-Promoting Complex/Cyclosome Controls Repair and Recombination by Ubiquitylating Rhp54 in Fission Yeast

(2008) M. Trickey et al.   MOLECULAR AND CELLULAR BIOLOGY

CHIP-Mediated Degradation and DNA Damage-Dependent Stabilization Regulate Base Excision Repair Proteins

(2008) Jason L. Parsons et al.   MOLECULAR CELL

A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication

(2008) Dipanjan Chowdhury et al.   MOLECULAR CELL

Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability

(2008) J. Blickwedehl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA