Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy

Turning Off AKT: PHLPP as a Drug Target

(2014) Alexandra C. Newton et al.   Annual Review of Pharmacology and Toxicology

PHLPP Is a Negative Regulator of RAF1, Which Reduces Colorectal Cancer Cell Motility and Prevents Tumor Progression in Mice

(2014) Xin Li et al.   GASTROENTEROLOGY

Signaling effectors underlying pathologic growth and remodeling of the heart

(2013) Jop H. van Berlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Phospholipase Cɛ links G protein-coupled receptor activation to inflammatory astrocytic responses

(2013) Stephanie S. Dusaban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-Term Akt Activation in Cardiac Muscle Cells Improves Contractile Function in Failing Hearts

(2012) Ichiro Shiojima et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload

(2012) Misun Park et al.   BASIC RESEARCH IN CARDIOLOGY

PHLPP1 Gene Deletion Protects the Brain from Ischemic Injury

(2012) Bo Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molecular basis of physiological heart growth: fundamental concepts and new players

(2012) Marjorie Maillet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy

(2011) Yinan Hua et al.   BASIC RESEARCH IN CARDIOLOGY

Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression

(2011) Muhan Chen et al.   CANCER CELL

PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth

(2011) J. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Myocardial AKT: The Omnipresent Nexus

(2011) Mark A. Sussman et al.   PHYSIOLOGICAL REVIEWS

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice

(2010) Chengqun Huang et al.   CIRCULATION

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

(2010) Izhak Kehat et al.   CIRCULATION

PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart

(2010) Shigeki Miyamoto et al.   CIRCULATION RESEARCH

PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus

(2010) Travis C. Jackson et al.   JOURNAL OF NEUROCHEMISTRY

Mst1 Is an Interacting Protein that Mediates PHLPPs' Induced Apoptosis

(2010) Meng Qiao et al.   MOLECULAR CELL

Akt Increases Sarcoplasmic Reticulum Ca2+Cycling by Direct Phosphorylation of Phospholamban at Thr17

(2009) Daniele Catalucci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt regulates L-type Ca2+channel activity by modulating Cavα1 protein stability

(2009) Daniele Catalucci et al.   JOURNAL OF CELL BIOLOGY

Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells

(2008) Stephan Schiekofer et al.   ANGIOGENESIS

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility

(2008) Marjorie Maillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

(2008) Jaetaek Kim et al.   MOLECULAR ENDOCRINOLOGY

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin

(2008) Tomoya Kitamura et al.   NATURE CELL BIOLOGY

Physiological myocardial hypertrophy: how and why?

(2007) Daniele Catalucci   Frontiers in Bioscience-Landmark