Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors

Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells

(2013) K M Dixon et al.   BRITISH JOURNAL OF CANCER

Apelin–APJ induces ICAM-1, VCAM-1 and MCP-1 expression via NF-κB/JNK signal pathway in human umbilical vein endothelial cells

(2012) Ying Lu et al.   AMINO ACIDS

The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways

(2012) Zaklina Kovacevic et al.   ANTIOXIDANTS & REDOX SIGNALING

Modulation of epithelial tight junctions by TGF-beta 3 in cultured oral epithelial cells

(2012) P Ye   AUSTRALIAN DENTAL JOURNAL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice

(2012) Yanzheng Tong et al.   CELL RESEARCH

Actin Cytoskeleton: A Team Effort during Actin Assembly

(2012) Laurent Blanchoin et al.   CURRENT BIOLOGY

N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis

(2012) Wen Liu et al.   EMBO Molecular Medicine

The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1)

(2012) Zhiqiang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JunB contributes to Id2 repression and the epithelial–mesenchymal transition in response to transforming growth factor–β

(2012) Megan Gervasi et al.   JOURNAL OF CELL BIOLOGY

The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription

(2012) Jelena Stanisavljevic et al.   JOURNAL OF CELL SCIENCE

Actin stress fibers - assembly, dynamics and biological roles

(2012) S. Tojkander et al.   JOURNAL OF CELL SCIENCE

DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin

(2012) A Mitra et al.   ONCOGENE

Vimentin and PSF Act in Concert to Regulate IbeA+ E. coli K1 Induced Activation and Nuclear Translocation of NF-κB in Human Brain Endothelial Cells

(2012) Feng Chi et al.   PLoS One

Functions of Nonmuscle Myosin II in Assembly of the Cellular Contractile System

(2012) Maria Shutova et al.   PLoS One

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

(2012) P. Nistico et al.   Cold Spring Harbor Perspectives in Biology

Phosphatidylinositol 3′-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1α and vascular endothelial growth factor expression

(2011) Yan Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part II

(2011) Jacek Wilczynski et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cells

(2011) Gang Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle

(2011) Catherine McCaig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Receptor activator of NF-κB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein

(2011) Naoto Hada et al.   BONE

c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition

(2011) Brian I. Carr et al.   CANCER BIOLOGY & THERAPY

NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma

(2011) Jun Cheng et al.   CANCER LETTERS

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

(2011) Tao Huang et al.   EMBO JOURNAL

Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells

(2011) Antonietta R. Farina et al.   FEBS LETTERS

Role of Rho GTPases and their regulators in cancer progression

(2011) Rajamani Rathinam   Frontiers in Bioscience-Landmark

Alterations in the Smad pathway in human cancers

(2011) Debangshu Samanta   Frontiers in Bioscience-Landmark

Nitric Oxide Suppresses Tumor Cell Migration through N-Myc Downstream-regulated Gene-1 (NDRG1) Expression

(2011) Jason R. Hickok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KAI1Gene Is Engaged inNDRG1Gene-mediated Metastasis Suppression through the ATF3-NFκB Complex in Human Prostate Cancer

(2011) Wen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

(2011) Sei Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncanonical TGF-β Signaling During Mammary Tumorigenesis

(2011) Jenny G. Parvani et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Induction of Caspase Mediated Apoptosis and Down-Regulation of Nuclear Factor-κB and Akt Signaling are Involved in the Synergistic Antitumor Effect of Gemcitabine and the Histone Deacetylase Inhibitor Trichostatin A in Human Bladder Cancer Cells

(2011) Hwang Gyun Jeon et al.   JOURNAL OF UROLOGY

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

(2011) Reason Wilken et al.   Molecular Cancer

Ndrg1 in development and maintenance of the myelin sheath

(2011) Rosalind H.M. King et al.   NEUROBIOLOGY OF DISEASE

N-myc Downstream-regulated Gene 1 (NDRG1) a Differentiation Marker of Human Breast Cancer

(2011) Abbas Fotovati et al.   PATHOLOGY & ONCOLOGY RESEARCH

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

The p85β regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling

(2010) Jiman He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells

(2010) Yuichi Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients

(2010) Maria Aparecida Nagai et al.   BREAST CANCER RESEARCH AND TREATMENT

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

(2010) Y Wu et al.   BRITISH JOURNAL OF CANCER

Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620

(2010) Qian Li et al.   CLINICAL & EXPERIMENTAL METASTASIS

β-Catenin and NF-κB cooperate to regulate the uPA/uPAR system in cancer cells

(2010) Marie Moreau et al.   INTERNATIONAL JOURNAL OF CANCER

Rho-associated kinase-dependent contraction of stress fibres and the organization of focal adhesions

(2010) K. Katoh et al.   Journal of the Royal Society Interface

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cortactin is involved in transforming growth factor- 1-induced epithelial-mesenchymal transition in AML-12 cells

(2009) K. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

NDRG1 and CRK-I/II are regulators of endothelial cell migration under intermittent hypoxia

(2009) Sébastien Toffoli et al.   ANGIOGENESIS

Smad2 and Smad3 Phosphorylated at Both Linker and COOH-Terminal Regions Transmit Malignant TGF-β Signal in Later Stages of Human Colorectal Cancer

(2009) Koichi Matsuzaki et al.   CANCER RESEARCH

N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of  B Kinase   Expression

(2009) F. Hosoi et al.   CANCER RESEARCH

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Signaling Through Rho GTPase Pathway as Viable Drug Target

(2009) Qun Lu et al.   CURRENT MEDICINAL CHEMISTRY

A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila

(2009) R. L. Webb et al.   DEVELOPMENT

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased expression of NDRG1 in glioma is related to tumor progression and survival of patients

(2009) Boqian Sun et al.   JOURNAL OF NEURO-ONCOLOGY

NDRG1/2 expression is inhibited in primary acute myeloid leukemia

(2009) Mario P. Tschan et al.   LEUKEMIA RESEARCH

Proximal events in Wnt signal transduction

(2009) Stephane Angers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: The potential role in proteolytic activation of PKCδ and apoptosis

(2009) Ying Zheng et al.   PROTEOMICS

The iron-regulated metastasis suppressor, Ndrg-1: Identification of novel molecular targets

(2008) Zaklina Kovacevic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

(2008) J. W. Tyner et al.   BLOOD

N-Myc down-regulated gene 1 mediates proliferation, invasion, and apoptosis of hepatocellular carcinoma cells

(2008) Xinrui Yan et al.   CANCER LETTERS

Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma

(2008) Shin Nishio et al.   CANCER LETTERS

Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

(2008) P. C. McDonald et al.   CANCER RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

In vivo role of lipid adducts on Wingless

(2008) X. Franch-Marro et al.   JOURNAL OF CELL SCIENCE

Chemotherapy-Induced CXC-Chemokine/CXC-Chemokine Receptor Signaling in Metastatic Prostate Cancer Cells Confers Resistance to Oxaliplatin through Potentiation of Nuclear Factor- B Transcription and Evasion of Apoptosis

(2008) C. Wilson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy

(2008) J A McCubrey et al.   LEUKEMIA

NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells

(2008) Su Chen et al.   LEUKEMIA RESEARCH

Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas

(2008) Bo Zhai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-κB activation

(2007) Venkatapuram Seenu Reddy et al.   JOURNAL OF CELLULAR PHYSIOLOGY