Article
Chemistry, Applied
Deepak Sharma, Pradeep Sharma
Summary: Hydroxypropylation of Cassia gum derived from ruderal Cassia tora species was studied using Taguchi's L'16 orthogonal array design of experiments. The optimized reaction conditions resulted in maximum hydroxypropyl content of 8.43% and 7.71% as determined by chromic acid titration and 1H NMR spectroscopic analysis. COSY and HSQC correlation spectral analysis confirmed the chemical shift values of substituted hydroxypropyl groups and the presence of C 6 of the beta-D-1, 4-linkedManp unit.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Ting Cai, Pei Shi, Shan Zhang, Wenliang Xiang, Junyu Liu, Zixi Lin, Jie Tang
Summary: Perilla frutescens essential oil (PEO) shows significant antifungal activity against pellicle formation microorganisms in Sichuan pickles and enhances the production of volatile compounds during fermentation, improving sensory acceptability.
Article
Chemistry, Physical
Shiyang Zhou, Gangliang Huang
Summary: Fresh aloe was used to prepare aloe polysaccharide through water extraction. Protein removal and dialysis were conducted for refinement. Aloe polysaccharide was separated and characterized, and its derivatives were synthesized for antioxidant testing. Aloe polysaccharide and its derivatives exhibited good antioxidant activity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Shilei Wang, Yuan Peng, Yixin Zhuang, Nan Wang, Jianchang Jin, Zhajun Zhan
Summary: Two polysaccharides, APS2-I and APS3-I, were purified from Radix Astragali water extract. They exhibited significant antioxidant and myocardial protection activities. In addition, treatment with total polysaccharides improved hemodynamic parameters and cardiac function in rat models of ischemia and reperfusion.
Article
Food Science & Technology
You-Yu Yan, Shuai Yuan, Hao-Hai Ma, Xi-Feng Zhang
Summary: Polysaccharides can chelate metal ions to form complexes with antioxidant properties, potentially serving as effective candidates for cancer treatment in the fields of functional food and pharmacology.
FOOD SCIENCE & NUTRITION
(2021)
Article
Chemistry, Applied
Shiyang Zhou, Gangliang Huang, Guangying Chen
Summary: The extracted and purified yam polysaccharide showed good antioxidant activity with a molecular weight of 7.28 x 104. The derivatives of yam polysaccharide, especially phosphorylated polysaccharide, had scavenging ability to hydroxyl radicals similar to VC, laying a theoretical foundation for the development of yam polysaccharide-related foods.
Article
Biochemistry & Molecular Biology
Lan Luo, Xuemei Song, Xiao Chang, Sheng Huang, Yunxi Zhou, Shengmei Yang, Yan Zhu, Lanyan Zhang, Yongsheng Wu, Junyin Zhang, Zhipeng Zhou, Mingyi Wu
Summary: This study purified and characterized two polysaccharides (BCG-1 and BCG-2) from BCG-PSN, revealing that they are an α-D-(1 -> 4)-mannan with (1 -> 2)-linked branches and an α-D-(1 -> 4)-glucan with (1 -> 6)-linked branches, respectively. The bioactivity assays showed that BCG-1 and BCG-2 could dose-dependently increase the production of inflammatory mediators and have similar or stronger effects compared to BCG-PSN injection.
Article
Chemistry, Physical
Wenjian Yang, Gangliang Huang
Summary: Acetylation, carboxymethylation, sulfation, and phosphorylation were performed on polysaccharide from Solanum tuberdsm (STP). Phosphorylated P-STP (P-STP) showed the lowest protein content and the highest total carbohydrate content among the four modified products. Carboxymethylated STP (CM-STP) had the highest degree of substitution (DS) of 0.699, while sulfated STP (S-STP) had the lowest DS of 0.211. FT-IR and NMR analysis confirmed the successful modification of STP.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Fazilet Gurer, Rupert Kargl, Matej Bracic, Damjan Makuc, Martin Thonhofer, Janez Plavec, Tamilselvan Mohan, Karin Stana Kleinschek
Summary: This study reports a one-step aqueous method for synthesizing isolated and purified polysaccharide-amino acid conjugates. Amino acid esters were successfully conjugated to a polysaccharide backbone via an amide bond, achieving a conjugation efficiency of 20-80%. This approach has the potential to tailor polysaccharide backbones containing di- or tri-peptides.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Baifei Hu, Huabing Yang, Guangming Chen, Xiongjie Sun, Xiaojuan Zou, Jun Ma, Xiaowei Yao, Qiong Liang, Hongtao Liu
Summary: This study demonstrated the potential of Bletilla striata oligosaccharides (BOs) as a functional food for the treatment of non-alcoholic fatty liver disease (NAFLD). By regulating hepatic metabolism and reducing lipid accumulation and fibrosis, BOs showed improvement in NAFLD.
Article
Environmental Sciences
Xianghao Meng, Duoji Luosang, Shujuan Meng, Rui Wang, Wenhong Fan, Dawei Liang, Xiaohu Li, Qian Zhao, Linyan Yang
Summary: The spatial configuration of polysaccharide foulant is significant in membrane fouling, controlling the resistance of gel layer formed on the membrane. Polysaccharides with different properties show distinct fouling mechanisms in accordance with Hermia's models. Cations may change the interaction of polysaccharide foulant, leading to structural changes in the gel layer.
Article
Chemistry, Applied
Tao Hong, Jun-Yi Yin, Shao-Ping Nie, Ming-Yong Xie
Summary: This paper highlights the importance of polysaccharides and the application of infrared spectroscopy in polysaccharide structural analysis. It emphasizes the close relationship between the functions and properties of polysaccharides and their structural features, as well as introduces some advanced IR techniques to enhance their application in polysaccharide structural elucidation.
Article
Chemistry, Applied
Hou-Kuan Zhao, Xian-Yong Wei, Yi-Min Xie
Summary: Polysaccharide was extracted from Grifola frondosa using supercritical CO2 technology, with optimal conditions determined for highest yield. The polysaccharide was purified with ionic liquid and characterized as a heteropolysaccharide with anti-tumour and antibacterial effects demonstrated in vitro.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Food Science & Technology
Nailin Huo, Kashif Ameer, Zhaogen Wu, Shengnan Yan, Guihun Jiang, Karna Ramachandraiah
Summary: This study investigated the effects of phosphorylation on the composition, structure, morphology, and radical-scavenging activities of Sanchi flower polysaccharides. The introduction of phosphate groups led to the formation of pore-like structures and enhanced radical-scavenging activities. These findings are important for the potential application of Sanchi flower polysaccharides.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Review
Polymer Science
Janja Trcek, Iztok Dogsa, Tomaz Accetto, David Stopar
Summary: Bacteria produce various multifunctional polysaccharides with advantages such as natural origin, sustainability, and biodegradability. Acetan is an important extracellular polysaccharide produced mainly by Komagataeibacter and Acetobacter species, with varying expression in different bacterial genera. Research has shown that all species of Komagataeibacter possess at least one acetan genetic cluster, while only one third of Acetobacter species surveyed have this genetic cluster.
Article
Microbiology
Thuy Minh Nguyen, Masaru Goto, Shohei Noda, Minenosuke Matsutani, Yuki Hodoya, Naoya Kataoka, Osao Adachi, Kazunobu Matsushita, Toshiharu Yakushi
Summary: This study identified 5-ketofructose reductase (KFR) as a key enzyme in the metabolism of 5-ketofructose, belonging to the shikimate dehydrogenase family. KFR has a unique substrate-binding site, and crucial amino acid residues are conserved in evolution, with their function experimentally validated. This research is of significance for a better understanding of the biosynthesis of low-calorie sweeteners and their potential applications.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tomoyuki Kosaka, Tatsuya Tsuzuno, Seiki Nishida, Sornsiri Pattanakittivorakul, Masayuki Murata, Isamu Miyakawa, Noppon Lertwattanasakul, Savitree Limtong, Mamoru Yamad
Summary: This study investigated the thermotolerance mechanism of Kluyveromyces marxianus at high temperatures. It revealed that the yeast can scavenge reactive oxygen species (ROS) through metabolic changes. This research is of significance for understanding the survival mechanism of this yeast in high-temperature environments.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Roni Miah, Shun Nina, Takeru Murate, Naoya Kataoka, Minenosuke Matsutani, Yoshitaka Ano, Kazunobu Matsushita, Toshiharu Yakushi
Summary: Two membrane-bound enzymes, pyrroloquinoline quinone-dependent alcohol dehydrogenase and molybdopterin-dependent aldehyde dehydrogenase (ALDH), play a crucial role in vinegar production by acetic acid bacteria. The oxidation of acetaldehyde leads to ubiquinone reduction in the cytoplasmic membrane. Through biochemical and genetic engineering approaches, the mechanism of ALDH has been investigated and it involves a complex interplay between different subunits and electron transfer processes. This research provides a better understanding of the vinegar fermentation process.
JOURNAL OF BACTERIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Naoya Kataoka, Minenosuke Matsutani, Ryutarou Murata, Ryo Koga, Nawarat Nantapong, Toshiharu Yakushi, Kazunobu Matsushita
Summary: This study focuses on the effect of potassium ion on cell growth of C. glutamicum at high temperatures. The results show that supplementation of high concentrations of potassium chloride can mitigate the repression of cell growth induced by high temperature. The presence of high osmolyte in the culture medium also helps inhibit the leakage of potassium ion caused by high temperature and support cell growth at high temperatures.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2022)
Article
Microbiology
Naoya Kataoka, Minenosuke Matsutani, Nami Matsumoto, Misuzu Oda, Yuki Mizumachi, Kohei Ito, Shuhei Tanaka, Yu Kanesaki, Toshiharu Yakushi, Kazunobu Matsushita
Summary: Acetic acid bacterium Komagataeibacter medellinensis NBRC 3288 was adapted to higher growth temperatures through experimental evolution, resulting in improved growth and fermentation ability. The adapted strains exhibited changes in cell morphology.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Sornsiri Pattanakittivorakul, Tatsuya Tsuzuno, Tomoyuki Kosaka, Masayuki Murata, Yu Kanesaki, Hirofumi Yoshikawa, Savitree Limtong, Mamoru Yamada
Summary: This study aims to develop multi-stress tolerant strains of Kluyveromyces marxianus through a novel evolutionary adaptation procedure called RLCGT, and to increase ethanol production at high temperatures. Four adapted strains showed increased tolerance to ethanol and other stress factors, as well as higher ethanol production at high temperatures. Possible mechanisms of stress tolerance in adapted strains were discussed based on genome and transcriptome analyses.
Article
Biotechnology & Applied Microbiology
Naoya Kataoka, Kotone Naoki, Yoshitaka Ano, Kazunobu Matsushita, Toshiharu Yakushi
Summary: An efficient 5KGA production system was developed using Gluconobacter japonicus. The catabolism of 5KGA and gluconate was blocked by deleting the gno and gntK genes. The addition of 1mM CaCl2 efficiently improved the conversion of glucose to 5KGA.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sunan Nuanpeng, Sudarat Thanonkeo, Preekamol Klanrit, Mamoru Yamada, Pornthap Thanonkeo
Summary: The optimal fermentation conditions for ethanol production from sweet sorghum juice by the thermotolerant yeast S. cerevisiae DBKKUY-53 were determined using statistical experimental design. It was found that yeast cell concentration, sugar concentration, and yeast extract were the significant independent fermentation factors affecting ethanol production. These factors were optimized and the maximum ethanol concentration and productivity were achieved. The results indicate that S. cerevisiae DBKKUY-53 has great potential for commercial ethanol production at high temperatures.
FERMENTATION-BASEL
(2023)
Article
Energy & Fuels
Kankanok Charoenpunthuwong, Preekamol Klanrit, Nuttaporn Chamnipa, Sudarat Thanonkeo, Mamoru Yamada, Pornthap Thanonkeo
Summary: This study evaluated the ethanol production potential of a recombinant Zymomonas mobilis R301 under normal and high-temperature conditions. It was found that the recombinant strain could produce ethanol and express genes related to heat shock response and ethanol production pathway. Therefore, it has great potential for ethanol production in tropical or subtropical areas.
Review
Biotechnology & Applied Microbiology
Haruthairat Kitwetcharoen, Ly Tu Phung, Preekamol Klanrit, Sudarat Thanonkeo, Patcharaporn Tippayawat, Mamoru Yamada, Pornthap Thanonkeo
Summary: Kombucha, a fermented beverage made from tea, sugar, and a culture of bacteria and yeasts known as SCOBY, has various health benefits and properties due to the presence of beneficial compounds like polyphenols, organic acids, amino acids, vitamins, minerals, organic nitrogens, and hydrolytic enzymes. This review discusses recent research on kombucha fermentation, the microbial community in SCOBY, the chemical composition of kombucha, and its health benefits. The adverse effects and prospects of kombucha production are also addressed.
FERMENTATION-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Masakatsu Usui, Hikari Kubota, Mizuki Ishihara, Haruka Matsuki, Shinya Kawabe, Yoshimasa Sugiura, Naoya Kataoka, Kazunobu Matsushita, Yoshitaka Ano, Yoshihiko Akakabe, Roque A. Hours, Toshiharu Yakushi, Osao Adachi
Summary: This study proposes a method for effectively eliminating toxic amines from fish and fishery products by coupling the fungal amine oxidase and bacterial aldehyde oxidase through a coupling reaction.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kakeru Nagaki, Naoya Kataoka, Gunjana Theeragool, Minenosuke Matsutani, Yoshitaka Ano, Kazunobu Matsushita, Toshiharu Yakushi
Summary: In this study, a co-cultivation system was constructed using two recombinant G. oxydans strains to produce protocatechuate from quinate.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Osao Adachi, Naoya Kataoka, Kazunobu Matsushita, Yoshihiko Akakabe, Toshihiro Harada, Toshiharu Yakushi
Summary: A membrane-bound d-mannose isomerase enzyme was found in acetic acid bacteria, which is different from previously reported cytoplasmic sugar isomerases. The enzyme showed optimal activity at pH 5.5, in contrast to alkaline optimal pH of cytoplasmic enzymes. It had stability to heat and the optimal reaction temperature was between 40-60 degrees C. The enzyme had a total molecular mass of 196 kDa composed of identical 4 subunits of 48 kDa. Washed or immobilized cells showed a high conversion ratio from d-mannose to d-fructose and vice versa. The enzyme's catalytic properties have potential biotechnological applications in high fructose syrup production from konjac taro.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Naoya Kataoka, Natsaran Saichana, Minenosuke Matsutani, Hirohide Toyama, Kazunobu Matsushita, Toshiharu Yakushi
Summary: A novel flavoprotein-cytochrome c complex d-gluconate dehydrogenase (GADH) encoded by gndXYZ of Gluconobacter oxydans NBRC 3293 was identified, which is phylogenetically distinct from previously reported GADHs encoded by gndFGH and gndSLC of Gluconobacter spp. The study revealed that GndXYZ has a high efficiency in converting d-gluconate to 2-keto-d-gluconate, indicating its potential for 2-keto-d-gluconate production.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Nami Matsumoto, Naoki Osumi, Minenosuke Matsutani, Theerisara Phathanathavorn, Naoya Kataoka, Gunjana Theeragool, Toshiharu Yakushi, Yasushi Shiraishi, Kazunobu Matsushita
Summary: This study successfully adapted Acetobacter pasteurianus K-1034 to high-temperature conditions by experimental evolution, resulting in strains that can grow well in low-nutrient media and efficiently produce vinegar under practical fermentation systems. The high-temperature fermentation ability of the adapted strains was comparable to previously obtained low-nutrient adapted strains.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
