Article
Biotechnology & Applied Microbiology
Zeyu Guo, Xianzhi Liu, Yiyi Lin, Zelin Sang, Dong Chen
Summary: This study demonstrates that multi-walled carbon nanotubes can inhibit tumor cell proliferation and promote apoptosis as an adjuvant nanomaterial in photothermal therapy. Additionally, multi-walled carbon nanotubes can suppress the mitochondrial pathway of tumor cells, leading to cell death. Therefore, multi-walled carbon nanotubes can function as efficient photothermal conversion materials for tumor photothermal therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Arun Kumar Ramu, Daoud Ali, Saud Alarifi, Mohamed Hussain Syed Abuthakir, Bakrudeen Ali Ahmed Abdul
Summary: Reserpine has therapeutic potential in inhibiting DNA repair, cell proliferation, and invasion while inducing apoptosis through modulation of TGF-beta signals.
Article
Cell Biology
Min Tang, Xin Dong, Lanbo Xiao, Zheqiong Tan, Xiangjian Luo, Lifang Yang, Wei Li, Feng Shi, Yueshuo Li, Lin Zhao, Na Liu, Qianqian Du, Longlong Xie, Jianmin Hu, Xinxian Weng, Jia Fan, Jian Zhou, Qiang Gao, Weizhong Wu, Xin Zhang, Weihua Liao, Ann M. Bode, Ya Cao
Summary: This study reveals that CPT1A is a determining factor for the abnormal activation of fatty acid oxidation in nasopharyngeal carcinoma cells. Its high expression impacts the malignant phenotypes of NPC and promotes nucleotide metabolism and cell cycle progression.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Sanjib Chaudhary, Ramesh Pothuraju, Satyanarayana Rachagani, Jawed A. Siddiqui, Pranita Atri, Kavita Mallya, Mohd W. Nasser, Zafar Sayed, Elizabeth R. Lyden, Lynette Smith, Siddhartha D. Gupta, Ranju Ralhan, Imayavaramban Lakshmanan, Dwight T. Jones, Apar Kishor Ganti, Muzafar A. Macha, Surinder K. Batra
Summary: This study demonstrates that the combination therapy of CDK4/6 and panEGFR inhibitors can significantly reduce tumor growth, induce cellular senescence, and regulate metabolic pathways in HNSCC, suggesting that dual targeting may be a critical therapeutic strategy in blocking tumor progression.
Review
Immunology
Wenting Li, Xiaobing Duan, Xingxing Chen, Meixiao Zhan, Haichuan Peng, Ya Meng, Xiaobin Li, Xian-Yang Li, Guofu Pang, Xiaohui Dou
Summary: Epstein-Barr virus (EBV) is the first tumor virus in humans, and nasopharyngeal carcinoma (NPC) accounts for 60% of new tumor cases caused by EBV worldwide annually. Over 90% of patients with undifferentiated NPC are infected with EBV. Immunotherapy has shown significant breakthroughs in the treatment of recurrent or metastatic NPC, providing a broad prospect for NPC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Wei Cai, Lin-Zhen Shu, Ding-Jie Liu, Lv Zhou, Meng-Meng Wang, Huan Deng
Summary: Cyclin D1 acts as a sensor for mitogenic signals by binding to CDK4/6 and plays a crucial role in integrating external mitogenic inputs and cell cycle progression. It interacts with transcription factors and regulates important cellular processes such as differentiation, proliferation, apoptosis, and DNA repair. Dysregulation of cyclin D1 contributes to the development of papillary thyroid carcinoma (PTC). Understanding the mechanisms behind cyclin D1 overexpression and its role in PTC tumorigenesis can lead to the identification of effective therapeutic strategies and the development of targeted treatment options.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jianbin Zhang, Yan Jiang, Ye Yu, Jiangping Li
Summary: This study evaluated the combination of TORC1/2 inhibitor sapanisertib and chemotherapy drug cisplatin for nasopharyngeal carcinoma (NPC) treatment. The results showed that sapanisertib effectively decreased NPC cell viability and proliferation, and acted synergistically with cisplatin to induce cell arrest and apoptosis. Sapanisertib had minimal effects on normal cells and also reduced NPC cell migration. These findings were evident in both in vitro and in vivo models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Ming-Yu Hsieh, Ming-Ju Hsieh, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mu-Kuan Chen, Ming-Chih Chou
Summary: The study found that Xanthohumol has a significant apoptotic effect and anticancer properties in human NPC cell lines, by regulating apoptosis-related proteins and the MAPK JNK pathway to promote cell apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Oncology
Wai Tong Ng, James C. H. Chow, Jonathan J. Beitler, June Corry, William Mendenhall, Anne W. M. Lee, K. Thomas Robbins, Sandra Nuyts, Nabil F. Saba, Robert Smee, William A. Stokes, Primoz Strojan, Alfio Ferlito
Summary: This article discusses the considerations, practical pearls, and recent advances in radiotherapy for nasopharyngeal carcinoma (NPC), emphasizing the importance of optimal radiotherapy planning and precise beam delivery for treatment efficacy.
Article
Virology
Nannan Zhu, Qian Wang, Zhidong Wu, Yan Wang, Mu-Sheng Zeng, Yan Yuan
Summary: Epstein-Barr virus (EBV) is associated with various malignant diseases, including nasopharyngeal carcinoma (NPC). The virus-encoded oncoprotein LMP1 promotes the development of cancer stem cells (CSCs) in NPC by activating the PI3K/mTOR/Akt signaling pathway. Different mTOR pathways, mTORC1 and mTORC2, contribute to the acquisition of distinct CSC characteristics and cooperate to regulate NPC metastasis.
JOURNAL OF VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fuchuan Xie, Wei Xiao, Yunming Tian, Yuhong Lan, Chi Zhang, Li Bai
Summary: MiR-195-3p is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell growth, decrease radioresistance, promote apoptosis, and impede cell cycle progression. It targets and regulates CDK1, impacting the radiosensitivity of NPC cells.
Article
Medicine, General & Internal
Dena Nadhim Mohammad, Ban Falih Ibraheem, Hassanain Hafidh Khudair, Darya Khalid Mahmood
Summary: This retrospective study aimed to investigate the pathological behavior of salivary tumors immuno-histochemically. Syndecan-1 and Cyclin D1 were found to play a significant role in the progression of salivary tumors. The expression of these markers varied in different types of tumors and cell compartments.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Juan Wang, Guoxiang Liu, Xiaojuan Li, Mengjie Huangfu, Yisa Liu, Xumei Li, Dan Yu, Luwei Zhou, Xu Chen
Summary: Curcumol induces autophagy through the AMPK/mTOR pathway in NPC cells, and inhibiting autophagy can increase proliferation while attenuating apoptosis and autophagy. Combining curcumol with the autophagy agonist rapamycin and apoptosis inducer MG132 synergizes the apoptotic and autophagic effect of curcumol, suggesting a potential new therapeutic strategy for NPC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mengying Zhu, Hui Wang, Yiluan Ding, Yuanyuan Yang, Zhuo Xu, Li Shi, Naixia Zhang
Summary: The study identified COH29 as a compound that can inhibit both RNR and USP2, with the ability to modulate the expression of cyclin D1 by enhancing its degradation. This suggests the potential of USP2 as a therapeutic target for cyclin D1-addicted cancers and COH29 as a starting compound for selective inhibitor development against USP2.
Review
Food Science & Technology
Ao Shang, Hong-Yan Liu, Min Luo, Yu Xia, Xiao Yang, Hang-Yu Li, Ding-Tao Wu, Quancai Sun, Fang Geng, Hua-Bin Li, Ren-You Gan
Summary: Sweet tea, long consumed as herbal tea for diabetes prevention and management, is rich in bioactive compounds, especially the nonclassical flavonoids dihydrochalcones. Main dihydrochalcones in sweet tea, including phlorizin, phloretin, and trilobatin, exhibit various health benefits such as antioxidant, anti-inflammatory, antimicrobial, cardioprotective, hepatoprotective, antidiabetic, and anticancer effects with potential application in preventing and managing chronic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Arakkaveettil Kabeer Farha, Ren-You Gan, Hua-Bin Li, Ding-Tao Wu, Atanas G. Atanasov, Khalid Gul, Jia-Rong Zhang, Qiong-Qiong Yang, Harold Corke
Summary: Rutin is a common dietary polyphenol found in vegetables, fruits, and other plants. It exhibits a variety of bioactive properties and can act as an anticancer agent by suppressing cell proliferation, inducing apoptosis or autophagy, and inhibiting angiogenesis and metastasis. Rutin can modulate multiple molecular targets involved in carcinogenesis.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Khalid Gul, Ren-You Gan, Cui-Xia Sun, Ge Jiao, Ding-Tao Wu, Hua-Bin Li, Ahmad Kenaan, Harold Corke, Ya-Peng Fang
Summary: This paper reviewed the design concepts, types, functionalities, and applications of hydrogels in food applications, with a focus on natural polymeric hydrogels. More research is needed to develop biomimetic hydrogels for different food applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Min Luo, Ren-You Gan, Bang-Yan Li, Qian-Qian Mao, Ao Shang, Xiao-Yu Xu, Hang-Yu Li, Hua-Bin Li
Summary: Tea, with its bioactive compounds, such as polyphenols and theanine, may have neuroprotective effects by regulating signaling pathways, inhibiting abnormal protein aggregation, normalizing hypothalamic-pituitary-adrenal axis activity, and providing antioxidant and anti-inflammatory properties. This narrative review summarizes the effects of tea on neurodegenerative and neuropsychiatric diseases, with special attention to the mechanisms of action.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Fang-Jun Lin, Hang Li, Ding-Tao Wu, Qi-Guo Zhuang, Hua-Bin Li, Fang Geng, Ren-You Gan
Summary: Zebrafish, a popular freshwater fish in aquariums and laboratories, has emerged as a valuable tool for rapidly screening safe and effective substances from natural products. With the ability to assess bioactivity and safety of natural products, zebrafish models show promising potential in discovering novel natural products with potential health benefits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Dan-Dan Zhou, Adila Saimaiti, Min Luo, Si-Yu Huang, Ruo-Gu Xiong, Ao Shang, Ren-You Gan, Hua-Bin Li
Summary: Tea residue can significantly increase the antioxidant activity and polyphenol concentration of kombucha, with green tea residue showing a stronger effect. This finding suggests that fermentation with tea residue can be a better strategy for producing polyphenol-rich kombucha beverages.
Article
Food Science & Technology
Ying-Hui Mai, Qi-Guo Zhuang, Qiao-Hong Li, Kui Du, Ding-Tao Wu, Hua-Bin Li, Yu Xia, Fan Zhu, Ren-You Gan
Summary: This study optimized the conditions for the extraction of antioxidants from 'Jinfeng' kiwifruit using ultrasound-assisted extraction and analyzed their antioxidant capacity, total phenolic and flavonoid contents, and antioxidant profiles. The results showed that 'Jinfeng' kiwifruit had high antioxidant capacity and antioxidant compound content under the optimal extraction conditions, making it a good dietary source of natural antioxidants.
Article
Food Science & Technology
Xiaoqin He, Peixiu Rong, Hongyan Liu, Bingcheng Gan, Dingtao Wu, Huabin Li, Renyou Gan
Summary: This study investigated the optimization of fermentation conditions for the production of Douchi koji using edible mushroom by-products and soybeans. The results showed that the activities of protease and beta-glucosidase were higher under the optimized conditions. Additionally, the fermented Douchi koji with edible mushroom by-product exhibited increased antioxidant capacity and improved nutritional value.
Review
Food Science & Technology
Ruo-Gu Xiong, Dan-Dan Zhou, Si-Xia Wu, Si-Yu Huang, Adila Saimaiti, Zhi-Jun Yang, Ao Shang, Cai-Ning Zhao, Ren-You Gan, Hua-Bin Li
Summary: The paper summarizes the health benefits of short-chain fatty acids (SCFAs) and examines their mechanisms of action. It provides valuable guidance for individuals consuming dietary fiber and for the development of functional foods for disease prevention.
Review
Food Science & Technology
Dan-Dan Zhou, Jiahui Li, Ruo-Gu Xiong, Adila Saimaiti, Si-Yu Huang, Si-Xia Wu, Zhi-Jun Yang, Ao Shang, Cai-Ning Zhao, Ren-You Gan, Hua-Bin Li
Summary: Grape is a popular fruit worldwide, containing a variety of bioactive compounds with potential health benefits. It has antioxidant, anti-inflammatory, anticancer effects, and is used to produce products like wine and grape juice. Grape pomace and grape seed also have applications in the food industry.
Article
Food Science & Technology
Hang-Yu Li, Si-Yu Huang, Ruo-Gu Xiong, Si-Xia Wu, Dan-Dan Zhou, Adila Saimaiti, Min Luo, Hui-Lian Zhu, Hua-Bin Li
Summary: This study found that theabrownin from dark tea significantly alleviated obesity by regulating gut microbiota-related metabolic pathways. Theabrownin reduced body weight gain and body fat accumulation, promoted lipid clearance, and had a hepatoprotective effect.
Article
Food Science & Technology
Bangyan Li, Qianqian Mao, Ruogu Xiong, Dandan Zhou, Siyu Huang, Adila Saimaiti, Ao Shang, Min Luo, Hangyu Li, Huabin Li, Sha Li
Summary: This study evaluated the protective effects of different black and dark teas on NAFLD induced by a high-fat diet and their regulation of gut microbiota. The results showed that these teas could reduce energy intake, alleviate fat accumulation, and prevent obesity and liver fat deposition. Moreover, they could also modulate the relative abundance of gut microbiota.
Review
Nutrition & Dietetics
Ruo-Gu Xiong, Jiahui Li, Jin Cheng, Dan-Dan Zhou, Si-Xia Wu, Si-Yu Huang, Adila Saimaiti, Zhi-Jun Yang, Ren-You Gan, Hua-Bin Li
Summary: The number of individuals with mental disorders has significantly increased in recent years, highlighting the importance of seeking prevention and treatment strategies. The gut microbiota, particularly Firmicutes and Bacteroidetes, have been shown to impact mental health through the microbiota-gut-brain axis, and dysbiosis of gut microbiota is related to mental disorders such as anxiety and depression. Dietary components, including probiotics, prebiotics, postbiotics, and various food items, have protective effects against mental disorders by modulating gut microbiota. This paper summarizes the gut microbiota associated with mental disorders and discusses the potential of dietary components in preventing and treating mental disorders.
Article
Biochemistry & Molecular Biology
Ruo-Gu Xiong, Si-Xia Wu, Jin Cheng, Adila Saimaiti, Qing Liu, Ao Shang, Dan-Dan Zhou, Si-Yu Huang, Ren-You Gan, Hua-Bin Li
Summary: This paper explores the production of two novel kombucha beverages with bamboo leaf or mulberry leaf, and compares the effects of fermentation with or without leaf residues on the antioxidant properties of kombucha. The results show that both types of kombucha have high antioxidant capacities, while kombucha fermented with bamboo leaf residues significantly enhances its antioxidant capabilities, total phenolic content, concentrations of some compounds, and sensory acceptability. Fermentation with leaf residues has no significant effect on mulberry leaf kombucha.
Article
Energy & Fuels
Pengfei Yao, Xiaohua Jiang
Summary: This paper analyzes harmonic distortion caused by the narrow pulse problem in matrix converters and proposes an improved switching pattern based on the basic five vector switching pattern. The improved pattern solves the narrow pulse problem by adding an additional zero vector and adjusting the sequence of the four active vectors to minimize switching times. Simulation and experimental results show that the proposed six vector switching pattern reduces low-frequency harmonics, decreases average switching frequency, attenuates sampling frequency harmonics, improves the THD of the output current, and has benefits in both normal and unbalanced input voltage conditions.
CSEE JOURNAL OF POWER AND ENERGY SYSTEMS
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
