Chemotherapy induced DNA damage response

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

(2012) Remko Prevo et al.   CANCER BIOLOGY & THERAPY

Chk2 Phosphorylation of Survivin- Ex3 Contributes to a DNA Damage-Sensing Checkpoint in Cancer

(2012) A. Lopergolo et al.   CANCER RESEARCH

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

NER and DDR: Classical music with new instruments

(2012) Sarah Sertic et al.   CELL CYCLE

Rac1 Protein Signaling Is Required for DNA Damage Response Stimulated by Topoisomerase II Poisons

(2012) Stefanie C. Huelsenbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells

(2012) H. J. Landau et al.   MOLECULAR CANCER THERAPEUTICS

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

(2012) S. Liu et al.   NUCLEIC ACIDS RESEARCH

DNA-PK, ATM and ATR collaboratively regulate p53–RPA interaction to facilitate homologous recombination DNA repair

(2012) M A Serrano et al.   ONCOGENE

Dose Dependent Effects on Cell Cycle Checkpoints and DNA Repair by Bendamustine

(2012) Neil Beeharry et al.   PLoS One

Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex

(2012) I. Ilves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

(2011) A Peasland et al.   BRITISH JOURNAL OF CANCER

DNA Repair: From Genome Maintenance to Biomarker and Therapeutic Target

(2011) S. Jalal et al.   CLINICAL CANCER RESEARCH

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

(2011) Edward A. Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation

(2011) J. A. Neal et al.   MOLECULAR AND CELLULAR BIOLOGY

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

ATR mediates cisplatin resistance in a p53 genotype-specific manner

(2011) N Sangster-Guity et al.   ONCOGENE

γH2Ax: Biomarker of Damage or Functional Participant in DNA Repair “All that Glitters Is not Gold!”

(2011) James E. Cleaver   PHOTOCHEMISTRY AND PHOTOBIOLOGY

DNA-PK-Dependent RPA2 Hyperphosphorylation Facilitates DNA Repair and Suppresses Sister Chromatid Exchange

(2011) Hungjiun Liaw et al.   PLoS One

Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation

(2011) S. Sertic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

Coordination of DNA–PK Activation and Nuclease Processing of DNA Termini in NHEJ

(2010) Katherine S Pawelczak et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeted Inhibition of Replication Protein A Reveals Cytotoxic Activity, Synergy with Chemotherapeutic DNA-Damaging Agents, and Insight into Cellular Function

(2010) S. C. Shuck et al.   CANCER RESEARCH

MDC1: The art of keeping things in focus

(2010) Stephanie Jungmichel et al.   CHROMOSOMA

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1

(2010) Verena Quennet et al.   NUCLEIC ACIDS RESEARCH

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

ATR: a master conductor of cellular responses to DNA replication stress

(2010) Rachel Litman Flynn et al.   TRENDS IN BIOCHEMICAL SCIENCES

The DNA-damage response: new molecular insights and new approaches to cancer therapy

(2009) Stephen P. Jackson   BIOCHEMICAL SOCIETY TRANSACTIONS

Association between Transcriptional Activity, Local Chromatin Structure, and the Efficiencies of Both Subpathways of Nucleotide Excision Repair of Melphalan Adducts

(2009) H. Episkopou et al.   CANCER RESEARCH

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress

(2009) J. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Ataxia telangiectasia and rad3-related kinase contributes to cell cycle arrest and survival after cisplatin but not oxaliplatin

(2009) K. A. Lewis et al.   MOLECULAR CANCER THERAPEUTICS

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Cisplatin-Induced DNA Damage Activates Replication Checkpoint Signaling Components that Differentially Affect Tumor Cell Survival

(2009) J. M. Wagner et al.   MOLECULAR PHARMACOLOGY

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology

(2008) Sarah C Shuck et al.   CELL RESEARCH

Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with Other Alkylating Agents

(2008) L. M. Leoni et al.   CLINICAL CANCER RESEARCH

Interplay of two major repair pathways in the processing of complex double-strand DNA breaks

(2008) Tracey A. Dobbs et al.   DNA REPAIR

Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase η-deficient human cells treated with cisplatin and oxaliplatin

(2008) Séverine Cruet-Hennequart et al.   DNA REPAIR

Differential Roles for Checkpoint Kinases in DNA Damage-dependent Degradation of the Cdc25A Protein Phosphatase

(2008) Jianping Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends

(2008) E. Weterings et al.   MOLECULAR AND CELLULAR BIOLOGY

Bendamustine

(2008) Michael J. Keating et al.   NATURE REVIEWS DRUG DISCOVERY

A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining

(2008) Katherine S. Pawelczak et al.   NUCLEIC ACIDS RESEARCH