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Title
Dysregulation of the mTOR pathway in p53-deficient mice
Authors
Keywords
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Journal
CANCER BIOLOGY & THERAPY
Volume 14, Issue 12, Pages 1182-1188
Publisher
Informa UK Limited
Online
2013-11-02
DOI
10.4161/cbt.26947
References
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Note: Only part of the references are listed.- DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
- (2016) Olga V. Leontieva et al. Aging-US
- p53: Pro-aging or pro-longevity?
- (2016) Peter L.J. de Keizer et al. Aging-US
- TP53 and MTOR crosstalk to regulate cellular senescence
- (2016) Lorenzo Galluzzi et al. Aging-US
- The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
- (2016) Lioubov G. Korotchkina et al. Aging-US
- Sestrins at the crossroad between stress and aging
- (2016) Jun Hee Lee et al. Aging-US
- p53 governs telomere regulation feedback too, via TRF2
- (2016) Izumi Horikawa et al. Aging-US
- Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
- (2016) Vjekoslav Dulic Aging-US
- Molecular damage in cancer: an argument for mTOR-driven aging
- (2016) Mikhail V. Blagosklonny Aging-US
- Reversing the aging stromal phenotype prevents carcinoma initiation
- (2016) Davina A. Lewis et al. Aging-US
- Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?
- (2016) Curtis J. Henry et al. Aging-US
- Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
- (2016) Linda S. Steelman et al. Aging-US
- If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
- (2016) Vladimir N. Anisimov et al. Aging-US
- Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
- (2016) Mikhail V. Blagosklonny Aging-US
- Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
- (2016) Lawrence A. Donehower Aging-US
- Geropotency: Increased malignant potential of aging neural progenitors
- (2016) Andrei M. Mikheev et al. Aging-US
- Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
- (2016) Olga V. Leontieva et al. Aging-US
- Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring
- (2016) Giovanni Vitale et al. Aging-US
- Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
- (2016) Elena A. Komarova et al. Aging-US
- cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad
- (2016) Mathew D. McGee et al. Aging-US
- Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
- (2016) Mikhail V. Blagosklonny Aging-US
- Caloric restriction: is mammalian life extension linked to p53?
- (2016) Paola Tucci Aging-US
- TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells
- (2016) Serena Altilia et al. Aging-US
- How to save Medicare: the anti-aging remedy
- (2016) Mikhail V. Blagosklonny Aging-US
- New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- (2016) Maria Comas et al. Aging-US
- Metformin in obesity, cancer and aging: addressing controversies
- (2016) Lev M. Berstein Aging-US
- Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
- (2015) Suzan K Chao et al. Oncotarget
- Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
- (2015) Esha Madan et al. Oncotarget
- PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes
- (2015) Filip Janku et al. Oncotarget
- The Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway
- (2015) Arnold J. Levine et al. Oncotarget
- Late-life rapamycin treatment reverses age-related heart dysfunction
- (2013) James M. Flynn et al. AGING CELL
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet
- (2013) O V Leontieva et al. Cell Death & Disease
- p53 induces transcriptional and translational programs to suppress cell proliferation and growth
- (2013) Fabricio Loayza-Puch et al. GENOME BIOLOGY
- Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment
- (2012) Isabelle Mercier et al. AMERICAN JOURNAL OF PATHOLOGY
- Rapalogs in cancer prevention
- (2012) Mikhail V. Blagosklonny CANCER BIOLOGY & THERAPY
- Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
- (2012) Tongyuan Li et al. CELL
- CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis
- (2012) Varun Prabhu et al. CELL CYCLE
- Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
- (2012) Marina Kolesnichenko et al. CELL CYCLE
- Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells
- (2012) Olga V. Leontieva et al. CELL CYCLE
- Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production
- (2012) Claudia Capparelli et al. CELL CYCLE
- Healthy Aging: Is Smaller Better? A Mini-Review
- (2012) Andrzej Bartke GERONTOLOGY
- Hypoxia suppresses conversion from proliferative arrest to cellular senescence
- (2012) O. V. Leontieva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs
- (2012) K. I. Leonova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A New Path to Longevity
- (2012) David Stipp SCIENTIFIC AMERICAN
- The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions
- (2011) Elizabeth M. Matthew et al. CELL CYCLE
- Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans
- (2011) J. Guevara-Aguirre et al. Science Translational Medicine
- Prevention of cancer by inhibiting aging
- (2010) Mikhail V Blagosklonny CANCER BIOLOGY & THERAPY
- A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice
- (2010) Katerina I. Leonova et al. CELL CYCLE
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
- (2010) Pankaj Kapahi et al. Cell Metabolism
- Paradoxical suppression of cellular senescence by p53
- (2010) Z. N. Demidenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
- (2010) Zhaohui Feng et al. TRENDS IN CELL BIOLOGY
- Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
- (2009) Rong Yuan et al. AGING CELL
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity
- (2009) M. M. Masternak et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- p53 and Metabolism: The GAMT Connection
- (2009) Yan Zhu et al. MOLECULAR CELL
- Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
- (2009) C. Selman et al. SCIENCE
- Functionally significant insulin-like growth factor I receptor mutations in centenarians
- (2008) Y. Suh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
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