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Agriculture, Dairy & Animal Science
Emanuele D'Anza, Francesco Buono, Sara Albarella, Elisa Castaldo, Mariagiulia Pugliano, Alessandra Iannuzzi, Ilaria Cascone, Edoardo Battista, Vincenzo Peretti, Francesca Ciotola
Summary: This study examines the relationship between intestinal strongyle infection and chromosome instability in Esperia ponies. The results show that ponies with higher fecal egg counts have increased levels of chromosome instability. Understanding the causes of this phenomenon can help in developing therapeutic strategies for managing intestinal parasites in horses and other livestock species. The implications of these findings for the management of the endangered Pony of Esperia breed are also discussed.
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Genetics & Heredity
Eric Heng, Sanjana Thanedar, Henry H. Heng
Summary: The powerful utilities of current DNA sequencing technology question the value of developing clinical cytogenetics any further. However, this article argues that clinical cytogenetics still has value in the genomic era, as karyotype dynamics play an important role in genomics and macroevolution and many diseases are linked to genomic variations. The proposed research frontiers include focusing on karyotypic heterogeneity, monitoring somatic evolution, and developing methods to integrate genomic data and cytogenomics.
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Oncology
Kavya Prasad, Mathew Bloomfield, Hagai Levi, Kristina Keuper, Sara Bernhard, Nicolaas C. Baudoin, Gil Leor, Yonatan Eliezer, Maybelline Giam, Cheng Kit Wong, Giulia Rancati, Zuzana Storchova, Daniela Cimini, Uri Ben-David
Summary: The interactions between whole-genome duplication and aneuploidy are crucial for tumor evolution, emphasizing the importance of considering genome status in the analysis and modeling of cancer aneuploidy.
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Biochemistry & Molecular Biology
Vera Dugina, Galina Shagieva, Mariya Novikova, Svetlana Lavrushkina, Olga Sokova, Igor Kireev, Pavel Kopnin
Summary: This study investigates the diverse roles of cytoplasmic actins in the progression of chromosomal instability in human breast cancer cells. Beta-cytoplasmic actin depletion leads to chromosomal instability progression, while downregulating gamma-cytoplasmic actin results in chromosome stability and reduced polyploidy and aneuploidy.
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Multidisciplinary Sciences
Kengo Yoshida, Yasunari Satoh, Arikuni Uchimura, Munechika Misumi, Seishi Kyoizumi, Masataka Taga, Yukiko Matsuda, Asao Noda, Yoichiro Kusunoki
Summary: Radiation exposure has been found to induce clonal hematopoiesis (CH) in elderly individuals, which is associated with hematologic malignancy and cardiovascular disease. This study used a mouse model to investigate the effects of radiation exposure on CH. The results showed that radiation exposure led to an increase in peripheral blood myeloid cells and red blood cell distribution width, and recurrent somatic mutations were observed specifically in the hematopoietic system. These findings highlight the development of massive CH due to radiation exposure and provide insights into the mutations involved in radiation-induced CH.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Lorenza Garribba, Stefano Santaguida
Summary: Proper partitioning of sister chromatids is crucial for maintaining cell stability. Errors in this process can lead to chromosome abnormalities and DNA damage, which can promote tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Lucia Paolini, Sajjad Hussain, Paul J. J. Galardy
Summary: Genomic instability is a central factor in the pathogenesis of human cancer. Most of the time, chromosome instability negatively affects cellular fitness, but in cancer it is usually associated with worse prognosis. Neuroblastoma, a common solid tumor in children, has two distinct patterns of genomic instability, with whole-chromosome aneuploidy associated with better prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Stefano J. Mandriota, Andre-Pascal Sappino
Summary: Aluminium, due to its versatility and abundance, is widely used in various products and applications, including cosmetics, food additives, and drinking water purification. However, the safety of aluminium has sparked debates in the scientific community, with increasing concerns about its potential mutagenic effects. This article explores the recent research data and ongoing discussions among scientists, industry, and regulatory bodies.
FRONTIERS IN ONCOLOGY
(2023)
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Biochemistry & Molecular Biology
Renee C. Duardo, Federico Guerra, Simona Pepe, Giovanni Capranico
Summary: Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ from the canonical B-DNA conformation. NCSs play important roles in physiological processes and have crucial implications for genome stability.
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Biochemistry & Molecular Biology
Laura Tovini, Sarah C. Johnson, Molly A. Guscott, Alexander M. Andersen, Diana Carolina Johanna Spierings, Rene Wardenaar, Floris Foijer, Sarah E. McClelland
Summary: Cancer cells exhibit persistent chromosomal instability, with different tumor types showing characteristic subsets of aneuploidies. Researchers used dCas9 as a carrier to recruit the kinetochore-nucleating domain of CENP-T protein to ectopically assemble kinetochores near specific genomic loci, resulting in increased chromosome instability and partial aneuploidies of target chromosomes in various cell types. The study also analyzed potential endogenous repeats that could support ectopic kinetochore formation.
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Agriculture, Dairy & Animal Science
Marta Kuchta-Gladysz, Ewa Wojcik, Anna Grzesiakowska, Katarzyna Rymuza, Olga Szeleszczuk
Summary: The paper explores the karyotypes of blue and silver foxes, as well as their hybrids, focusing on A and B chromosome numbers and fragile site frequencies. Genome stability is influenced by Robertsonian translocations in blue foxes and B chromosomes in silver foxes. The study uses fragile sites assay as a biomarker to evaluate genome stability in foxes, with a lower frequency of instabilities observed in healthy individuals. The assay can assist in selecting individuals with stable genomes for breeding, particularly for the conservation of endangered species like the blue fox.
Review
Biochemistry & Molecular Biology
Shalaka Patil, Sanika Jahagirdar, Maithilee Khot, Kundan Sengupta
Summary: Chromosomal instability (CIN) is associated with gastrointestinal (GI) tract cancers, and organoids provide a more realistic model to study the interaction between tumor cells and the tissue microenvironment and its impact on chromosomal stability.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Ivan Y. Iourov, Yuri B. Yurov, Svetlana G. Vorsanova, Sergei I. Kutsev
Summary: Chromosome instability (CIN) has been linked to aging and neurodegenerative diseases, with a possible role in cellular senescence and neuronal cell death. Despite the debate surrounding the occurrence of CIN in the aging brain, its impact on cellular aging and neurodegeneration is significant.
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Genetics & Heredity
Paul Dremsek, Thomas Schwarz, Beatrix Weil, Alina Malashka, Franco Laccone, Juergen Neesen
Summary: Optical genome mapping has emerged as a promising method for detecting large-scale structural variants in human genomes, but further research is needed to understand its applications and limitations.
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Genetics & Heredity
Kristina Keuper, Angela Wieland, Markus Raeschle, Zuzana Storchova
Summary: Cancer genome sequencing has revealed a complex landscape of chromosomal variants and alterations, providing insights into the molecular mechanisms underlying chromosomal aberrations formation.
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Biochemistry & Molecular Biology
Henry H. Heng, Steven D. Horne, Sophia Chaudhry, Sarah M. Regan, Guo Liu, Batoul Y. Abdallah, Christine J. Ye
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Biochemistry & Molecular Biology
Guo Liu, Christine J. Ye, Saroj K. Chowdhury, Batoul Y. Abdallahl, Steven D. Horne, Denise Nichols, Henry H. Heng
Review
Oncology
Joshua B. Stevens, Steven D. Horne, Batoul Y. Abdallah, Christine J. Ye, Henry H. Heng
CANCER AND METASTASIS REVIEWS
(2013)
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Cell Biology
Guo Liu, Joshua B. Stevens, Steven D. Horne, Batoul Y. Abdallah, Karen J. Ye, Steven W. Bremer, Christine J. Ye, David J. Chen, Henry H. Heng
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Cell Biology
Batoul Y. Abdallah, Steven D. Horne, Joshua B. Stevens, Guo Liu, Andrew Y. Ying, Barbara Vanderhyden, Stephen A. Krawetz, Root Gorelick, Henry H. Q. Heng
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Cell Biology
H. H. Q. Heng, G. Liu, J. B. Stevens, B. Y. Abdallah, S. D. Horne, K. J. Ye, S. W. Bremer, S. K. Chowdhury, C. J. Ye
CYTOGENETIC AND GENOME RESEARCH
(2013)
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Cell Biology
J. B. Stevens, B. Y. Abdallah, G. Liu, S. D. Horne, S. W. Bremer, K. J. Ye, J. Y. Huang, M. Kurkinen, C. J. Ye, H. H. Q. Heng
CYTOGENETIC AND GENOME RESEARCH
(2013)
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Oncology
Joshua B. Stevens, Guo Liu, Batoul Y. Abdallah, Steven D. Horne, Karen J. Ye, Steven W. Bremer, Christine J. Ye, Stephen A. Krawetz, Henry H. Heng
INTERNATIONAL JOURNAL OF CANCER
(2014)
Review
Oncology
Steven D. Horne, Sarah A. Pollick, Henry H. Q. Heng
INTERNATIONAL JOURNAL OF CANCER
(2015)
Review
Cell Biology
Steven D. Horne, Joshua B. Stevens, Batoul Y. Abdallah, Guo Liu, Steven W. Bremer, Christine J. Ye, Henry H. Q. Heng
JOURNAL OF CELLULAR PHYSIOLOGY
(2013)
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Oncology
Daochun Sun, Ramsi Haddad, Janice M. Kraniak, Steven D. Home, Michael A. Tainsky
MOLECULAR CANCER RESEARCH
(2013)
Review
Andrology
Batoul Y. Abdallah, Steven D. Horne, Markku Kurkinen, Joshua B. Stevens, Guo Liu, Christine J. Ye, Justin Barbat, Steven W. Bremer, Henry H. Q. Heng
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2014)
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Genetics & Heredity
Steven D. Horne, Saroj K. Chowdhury, Henry H. Q. Heng
FRONTIERS IN GENETICS
(2014)
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Genetics & Heredity
Christine J. Ye, Zachary Sharpe, Sarah Alemara, Stephanie Mackenzie, Guo Liu, Batoul Abdallah, Steve Horne, Sarah Regan, Henry H. Heng