Cationic ruthenium(III) maltolato–imidazole complexes — Synthesis, characterization, and antiproliferatory activity*Adapted from the Ph.D. thesis of D.C. Kennedy (see the References section).

Perspectives for Novel Mixed Diruthenium-Organic Drugs as Metallopharmaceuticals in Cancer Therapy

(2012) Denise de Oliveira Silva   Anti-Cancer Agents in Medicinal Chemistry

Pharmacokinetic study of sodium trans[tetrachlorobis(1H-indazole)-ruthenate (III)]/-indazole hydrochloride (1:1.1) (FFC14A) in patients with solid tumors

(2011) M.M. Henke et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

DNA binding, cytotoxicity, and apoptotic-inducing activity of ruthenium(II) polypyridyl complex

(2010) P. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Characterization of a Ruthenium(III)/NAMI-A Adduct with Bovine Serum Albumin that Exhibits a High Anti-Metastatic Activity

(2010) Mimi Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, Structure, and Selective Cytotoxicity of Organometallic Cp*RuIIO-Alkyl-N-phenylcarbamate Sandwich Complexes

(2010) Bradley T. Loughrey et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

2-(3,5-Dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthrolinoruthenium(II) complexes: synthesis, characterization, cytotoxicity, apoptosis, DNA-binding and antioxidant activity

(2010) Yun-Jun Liu et al.   BIOMETALS

Syntheses of ruthenium(II)-4,4′-biimidazole complexes and their potential anti-tumour activity

(2010) David C. Kennedy et al.   CANADIAN JOURNAL OF CHEMISTRY

Ruthenium-based chemotherapeutics: are they ready for prime time?

(2010) Emmanuel S. Antonarakis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

(2010) Hanzhong Ke et al.   CHEMICAL COMMUNICATIONS

Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS)

(2010) Jonathan P. Williams et al.   CHEMICAL COMMUNICATIONS

In vitro Ruthenation of Human Breast Cancer Suppressor Gene 1 (BRCA1) by the Antimetastasis Compound RAPTA-C and Its Analogue CarboRAPTA-C

(2010) Adisorn Ratanaphan et al.   CHEMISTRY & BIODIVERSITY

Synthesis, Structure, DNA-Binding Properties, and Cytotoxicity of Ruthenium(II) Polypyridyl Complexes

(2010) Yun-Jun Liu et al.   CHEMISTRY & BIODIVERSITY

Energetics, Conformation, and Recognition of DNA Duplexes Modified by Monodentate RuIIComplexes Containing Terphenyl Arenes

(2010) Olga Novakova et al.   CHEMISTRY-A EUROPEAN JOURNAL

Complex formation between Ru(η6-p-cym)(H2O)3]2+ and (O,O) donor ligands with biological relevance in aqueous solution

(2010) Linda Bíró et al.   DALTON TRANSACTIONS

Synthesis, single-crystal and solution structure analysis and in vitro cytotoxic activity of two novel complexes of ruthenium(ii) with in situ formed flavanone-based ligands.

(2010) Justyn Ochocki et al.   DALTON TRANSACTIONS

Antitumor activity of new hydridotris(pyrazolyl)borate ruthenium(ii) complexes containing the phosphanes PTA and 1-CH3–PTA

(2010) Almudena García-Fernández et al.   DALTON TRANSACTIONS

Discovery of a strongly apoptotic ruthenium complex through combinatorial coordination chemistry

(2010) Seann P. Mulcahy et al.   DALTON TRANSACTIONS

Osmium(ii)–versus ruthenium(ii)–arene carbohydrate-based anticancer compounds: similarities and differences

(2010) Muhammad Hanif et al.   DALTON TRANSACTIONS

Thiophenolato-bridged dinuclear arene ruthenium complexes: a new family of highly cytotoxic anticancer agents

(2010) Michaël Gras et al.   DALTON TRANSACTIONS

Ru(η6-arene) complexes of combretastatin-analogous oxazoles with enhanced anti-tumoral impact

(2010) Bernhard Biersack et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Controlling the Reactivity of Ruthenium(II) Arene Complexes by Tether Ring-Opening

(2010) Ana M. Pizarro et al.   INORGANIC CHEMISTRY

Is the Reactivity of M(II)−Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter?

(2010) Muhammad Hanif et al.   INORGANIC CHEMISTRY

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

(2010) Tianfeng Chen et al.   INORGANIC CHEMISTRY

Use of Perfluorinated Phosphines to Provide Thermomorphic Anticancer Complexes for Heat-Based Tumor Targeting

(2010) Anna K. Renfrew et al.   INORGANIC CHEMISTRY

Binding to DNA purine bases and amino acid residues of a ruthenium(II) antitumor complex: A density functional study

(2010) Yanfang Wu et al.   INORGANICA CHIMICA ACTA

New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy

(2010) M. Helena Garcia et al.   INORGANICA CHIMICA ACTA

Anticancer activities of the ruthenium carboxylato, amido and pyridine complexes

(2010) Srivastava   INTERNATIONAL JOURNAL OF ONCOLOGY

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

(2010) Petra Heffeter et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metabolization of [Ru(η6-C6H5CF3)(pta)Cl2]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand

(2010) Alexander E. Egger et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3β

(2010) G. Ekin Atilla-Gokcumen et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy

(2010) Lukas K. Filak et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Synthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles

(2010) Georg Süss-Fink et al.   JOURNAL OF CLUSTER SCIENCE

Synthesis, characterization, antitumor, and cytotoxic activity of mononuclear Ru(II) complexes

(2010) Sreekanth Thota et al.   JOURNAL OF COORDINATION CHEMISTRY

Overview and Frontier for the Development of Metallopharmaceutics

(2010) Hiromu Sakurai   JOURNAL OF HEALTH SCIENCE

Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes

(2010) Camilla C. Golfeto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands

(2010) Virtudes Moreno et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

From hydrolytically labile to hydrolytically stable RuII–arene anticancer complexes with carbohydrate-derived co-ligands

(2010) Muhammad Hanif et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and Biological Activities of Transition Metal Complexes Based on Acetylsalicylic Acid as Neo-Anticancer Agents

(2010) Gerhard Rubner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Bimetallic Titanocene−Ruthenium−Arene Complexes As Anticancer Agents: Relationships between Structural and Biological Properties

(2010) Frédéric Pelletier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium−Porphyrin Conjugates with Cytotoxic and Phototoxic Antitumor Activity

(2010) Teresa Gianferrara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrone derivatives and metals: From natural products to metal-based drugs

(2010) Wolfgang Kandioller et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Adding diversity to ruthenium(II)–arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains

(2010) Anna K. Renfrew et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

DNA Binding to an Anticancer Organo-Ruthenium Complex

(2010) Marcelina Klajner et al.   JOURNAL OF PHYSICAL CHEMISTRY B

New Platinum and Ruthenium Complexes - the Latest Class of Potential Chemotherapeutic Drugs - a Review of Recent Developments in the Field

(2010) Amr Amin et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity

(2010) Lukas K. Filak et al.   ORGANOMETALLICS

Biomedical Properties of a Series of Ruthenium-N-Heterocyclic Carbene Complexes Based on Oxidant Activity In Vitro and Assessment In Vivo of Biosafety in Zebrafish Embryos

(2010) Juan M. Alfaro et al.   Zebrafish

Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene RuII anticancer complex

(2010) Hong-Ke Liu et al.   Chemical Science

The Ruthenium Complex cis-(Dichloro)tetraammineruthenium(III) Chloride Presents Selective Cytotoxicity Against Murine B Cell Lymphoma (A-20), Murine Ascitic Sarcoma 180 (S-180), Human Breast Adenocarcinoma (SK-BR-3), and Human T Cell Leukemia (Jurkat) Tumor Cell Lines

(2009) Elisângela de Paula Silveira-Lacerda et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species

(2009) Ingo Ott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The novel ruthenium—γ-linolenic complex [Ru2(aGLA)4Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosisin vitro

(2009) Geise Ribeiro et al.   CELL BIOCHEMISTRY AND FUNCTION

Lipid based nanovectors containing ruthenium complexes: a potential route in cancer therapy

(2009) Mauro Vaccaro et al.   CHEMICAL COMMUNICATIONS

DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3′)TPP-Ru(phen)2Cl]Cl and its heterometallic derivatives

(2009) Yanan Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Ruthenium(II) Arene Compounds as Versatile Anticancer Agents

(2009) Anna Renfrew   CHIMIA

A categorization of metal anticancer compounds based on their mode of action

(2009) Teresa Gianferrara et al.   DALTON TRANSACTIONS

Synthesis, structural characterisation and solution chemistry of ruthenium(III) triazole-thiadiazine complexes

(2009) Massimiliano Delferro et al.   DALTON TRANSACTIONS

Nuclear targets of photodynamic tridentate ruthenium complexes

(2009) Ran Zhao et al.   DALTON TRANSACTIONS

A novel ruthenium(ii) arene based intercalator with potent anticancer activity

(2009) José Ruiz et al.   DALTON TRANSACTIONS

A novel ruthenium(iii) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity

(2009) Jimmy A. van Rijn et al.   DALTON TRANSACTIONS

Dual anti-angiogenic and cytotoxic properties of ruthenium(iii) complexes containing pyrazolato and/or pyrazole ligands

(2009) Raymond Wai-Yin Sun et al.   DALTON TRANSACTIONS

Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

(2009) Kenneth D. Camm et al.   DALTON TRANSACTIONS

Microwave synthesis of mixed ligand diimine–thiosemicarbazone complexes of ruthenium(ii): biophysical reactivity and cytotoxicity

(2009) Floyd A. Beckford et al.   DALTON TRANSACTIONS

[Tris(pyrazolyl)methane]ruthenium Complexes Capable of Inhibiting Cancer Cell Growth

(2009) Jesse M. Walker et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Ruthenium(II)–arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity

(2009) Sanja Grgurić-Šipka et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium’s success?

(2009) Simon M Page et al.   Future Medicinal Chemistry

Synthesis, Characterization, and in vitro Antimalarial and Antitumor Activity of New Ruthenium(II) Complexes of Chloroquine

(2009) Chandima S. K. Rajapakse et al.   INORGANIC CHEMISTRY

Ligand-Based Neutral Ruthenium(II) Arene Complex: Selective Anticancer Action

(2009) Chun-Hui Wu et al.   INORGANIC CHEMISTRY

Ruthenium(II) Arene Anticancer Complexes with Redox-Active Diamine Ligands

(2009) Tijana Bugarcic et al.   INORGANIC CHEMISTRY

In Vitro Transcription Inhibition by Ruthenium(II) Polypyridyl Complexes with Electropositive Ancillary Ligands

(2009) Feng Gao et al.   INORGANIC CHEMISTRY

Tetranuclear Coordination Assemblies Based on Half-Sandwich Ruthenium(II) Complexes: Noncovalent Binding to DNA and Cytotoxicity

(2009) Fátima Linares et al.   INORGANIC CHEMISTRY

Electronic structural investigations of ruthenium compounds and anticancer prodrugs

(2009) Travis V. Harris et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase

(2009) Bradley T. Loughrey et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate

(2009) L. Giovagnini et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands

(2009) M. Helena Garcia et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Cytotoxicity of half sandwich ruthenium(II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action

(2009) Sangeeta Das et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Trans–cis–cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B

(2009) Pasquale Mura et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Amide Linkage Isomerism As an Activity Switch for Organometallic Osmium and Ruthenium Anticancer Complexes

(2009) Sabine H. van Rijt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Binding of Organometallic Ruthenium(II) Anticancer Compounds to Nucleobases: A Computational Study†

(2009) Christian Gossens et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Influence of Oxygenation on the Reactivity of Ruthenium−Thiolato Bonds in Arene Anticancer Complexes: Insights from XAS and DFT

(2009) Thamayanthy Sriskandakumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent developments in ruthenium anticancer drugs

(2009) Aviva Levina et al.   Metallomics

DNA photocleavage in anaerobic conditions by a Ru(ii) polypyridyl complex with long wavelength MLCT absorption

(2009) Qian-Xiong Zhou et al.   NEW JOURNAL OF CHEMISTRY

In Vitro Expression and Redistribution of Nucleolar Proteins Following the Treatment With cis-Dichloro-1,2-propylenediamine-N,N,N′,N′-tetraacetato Ruthenium (III) (RAP)

(2009) Fatima Azzahra Delmani et al.   ONCOLOGY RESEARCH

From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro

(2009) Wolfgang Kandioller et al.   ORGANOMETALLICS

Rational Design of Highly Cytotoxic η6-Arene β-Diketiminato−Ruthenium Complexes

(2009) Andrew D. Phillips et al.   ORGANOMETALLICS

A theoretical study on the hydrolysis process of two Keppler-type antitumor complexes [TzH][trans-RuCl4(Tz)2] and [2-NH2TzH][trans-RuCl4(2-NH2Tz)2]

(2009) Jin-Can Chen et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structural characterization and cytotoxicity studies of ruthenium(II)–dmso–chloro complexes of chalcone and flavone derivatives

(2009) Rishikesh Prajapati et al.   POLYHEDRON

Quantum-chemical study of the potential anti-cancer drug Ru–NAMI-A in complex with estrogen and the simulated VA and VCD spectra of estrogen, the Ru–NAMI-A drug, and possible/proposed estrogen–Ru–NAMI-A complexes

(2009) Michaela Knapp-Mohammady et al.   THEORETICAL CHEMISTRY ACCOUNTS

Addition of ethynylferrocene to transition-metal complexes containing a chelating 1,2-dicarba-closo-dodecaborane-1,2-dichalcogenolate ligand—in vitro cooperativity of a ruthenium compound on cellular uptake of an anticancer drug

(2008) De-Hong Wu et al.   DALTON TRANSACTIONS

Cytotoxic and genotoxic effects of [Ru(phi)3]2+ evaluated by Ames/Salmonella and MTT methods

(2008) Kadriye Benkli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

(2008) Frédéric Schmitt et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Interactions of the “piano-stool” [ruthenium(II) (η6-arene)(en)CL]+complexes with water and nucleobases; ab initio and DFT study

(2008) Zdeněk Futera et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Ru(III) complexes derived from N -methyl derivatives of glycine and 1,3-propylenediamine- N , N ′-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC

(2008) Vesna M. Djinovic et al.   JOURNAL OF COORDINATION CHEMISTRY

DNA interaction studies of tridentate bridged Ru(II)–Pt(II) mixed-metal supramolecules

(2008) Aaron J. Prussin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety

(2008) Wolfgang Kandioller et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Glycal–ruthenium carbonyl clusters: Syntheses, characterization, and anticancer activity

(2008) V.D. Reddy et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

From cisplatin to photoreactive Ru complexes: targeting DNA for biomedical applications

(2008) Cécile Moucheron   NEW JOURNAL OF CHEMISTRY