Journal
DALTON TRANSACTIONS
Volume -, Issue 48, Pages 10727-10730Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b909520a
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- Technology Foundation STW
- Netherlands Organization for Scientific Research (CW-NWO)
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Tris(o-anisyl) phosphane was reacted with ruthenium(III) chloride forming a novel Ru(III) complex of formula [Ru(PAn(3))(P(An)(phenolate)(2))Cl] containing a tridentate dianionic P,O,O-ligand and a bidentate neutral P,O ligand. The tridentate ligand was formed by elimination of two methyl groups from the starting ligand in the reaction with the ruthenium salt. The molecular structure was determined by single crystal X-ray diffraction analysis. The compound shows a high cytotoxic activity in ovarian cancer cell lines comparable with cisplatin and overcoming cisplatin-resistance.
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