Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 103, Issue 3, Pages 427-431Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2008.12.008
Keywords
Mixed-metal; Supramolecular; Cisplatin; DNA interaction; Bioactive site; Light absorber; Ruthenium; Platinum; Tridentate; Bridging ligand
Funding
- National Science Foundation [CHE-0408445]
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Reported herein are studies of the concentration and temperature dependent interactions with DNA of the stereochemically defined mixed-metal supramolecular complexes, [(tpy)Ru(tppz)PtCl](PF6)(3) and [ClPt(tppz)Ru(tppz)PtCl](PF6)(4) (tpy = 2,2':6',2 ''-terpyridine and tppz = 2,3,5,6-tetrakis(2-pyridyl)pyrazine). These metal complexes couple a ruthenium based light absorber (LA) to the bioactive platinum sites (BAS) using a tridentate bridging ligand (BL). The complexes exhibit intense Ru --> tppz(pi*) metal to ligand charge transfer (MLCT) transitions in the visible region and adopt a square planar geometry around the Pt(II) center. The effect of incubating these metal complexes with DNA on the subsequent migration of DNA through an agarose gel was found to be more dramatic than that observed for the well known anticancer drug, cis-[Pt(NH3)(2)Cl-2] (Cisplatin). This effect was enhanced with increased incubation temperature. Unwinding Of supercoiled plasmid DNA was found to be more pronounced for the trimetallic complex, [ClPt(tppz)Ru(tppz)PtCl](PF6)(4), than for the bimetallic complex, [(tpy)Ru(tppz)PtCl](PF6)(3). (C) 2008 Elsevier Inc. All rights reserved.
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