Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 103, Issue 3, Pages 354-361Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2008.11.016
Keywords
Atomic force microscopy (AFM); Ruthenium(II); Cyclopentadienyl derivatives; X-ray structures; Antiproliferative assays
Funding
- Fundacao para a Ciencia e Tecnologia [POCTI/QUI/48433/2002]
- Ministerio Educacion y Ciencia [BQU2005-01834]
- FCT [SFRH/BD/12432/2003]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/12432/2003] Funding Source: FCT
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Inhibition of the growth of LoVo human colon adenocarcinoma and MiaPaCa pancreatic cancer cell lines by two new organometallic ruthenium(II) complexes of general formula [Ru(eta(5)-C5H5)(PP) L][CF3SO3], where PP is 1,2-bis(diphenylphosphino)ethane and L is 1,3,5-triazine (Tzn) 1 or PP is 2x triphenylphosphine and L is pyridazine (Pyd) 2 has been investigated. Crystal structures of compounds I and 2 were determined by X-ray diffraction studies. Atomic force microscopy (AFM) images suggest different mechanisms of interaction with the plasmid pBR322 DNA; while the mode of binding of compound 1 could be intercalation between base pairs of DNA, compound 2 might be involved in a covalent bond formation with N from the purine base. (C) 2008 Elsevier Inc. All rights reserved.
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