My road to Damascus: how I converted to the prohormone theory and the proprotein convertases

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture

(2011) J. Mayne et al.   CLINICAL CHEMISTRY

Quantitative Proteomic Analysis of PCSK9 Gain of Function in Human Hepatic HuH7 Cells

(2011) Nicholas Denis et al.   JOURNAL OF PROTEOME RESEARCH

Genomics of Cardiovascular Disease

(2011) Christopher J. O'Donnell et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Influence of PCSK9 Polymorphisms on Serum Low-Density Lipoprotein Cholesterol and Risk of Atherosclerosis

(2010) Jean Davignon et al.   Current Atherosclerosis Reports

PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides

(2010) Jeffrey Gagnon et al.   LIFE SCIENCES

Rare Cell Proteomic Reactor Applied to Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Quantitative Proteomics Study of Human Embryonic Stem Cell Differentiation

(2010) Ruijun Tian et al.   MOLECULAR & CELLULAR PROTEOMICS

Commentary PCSK9 variants: A new database

(2009) Sarah E.A. Leigh et al.   ATHEROSCLEROSIS

The molecular basis of familial hypercholesterolemia in Lebanon: Spectrum ofLDLRmutations and role ofPCSK9as a modifier gene

(2009) Marianne Abifadel et al.   HUMAN MUTATION

A new method for measurement of total plasma PCSK9: clinical applications

(2009) Geneviève Dubuc et al.   JOURNAL OF LIPID RESEARCH

Proprotein convertases as therapeutic targets

(2008) Michel Chrétien et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PCSK9 as a therapeutic target of dyslipidemia

(2008) Nabil G Seidah   EXPERT OPINION ON THERAPEUTIC TARGETS

Knock-out mouse models of proprotein convertases: unique functions or redundancy?

(2008) John et al.   Frontiers in Bioscience-Landmark

Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7

(2008) N Scamuffa et al.   GUT

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

(2008) Ahmed Zaid et al.   HEPATOLOGY

Inhibition of Chikungunya Virus Infection in Cultured Human Muscle Cells by Furin Inhibitors

(2008) Simona Ozden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PCSK9: a convertase that coordinates LDL catabolism

(2008) Jay D. Horton et al.   JOURNAL OF LIPID RESEARCH

Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine

(2008) Jeffrey Gagnon et al.   REGULATORY PEPTIDES