Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

Decreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity

(2014) Mehrdad Alirezaei et al.   Autophagy

The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Transporters

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lapatinib induces p27Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

(2013) Lin Tang et al.   CELL CYCLE

Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro

(2013) Grzegorz A. Czapski et al.   FEBS LETTERS

RON Receptor Tyrosine Kinase, a Negative Regulator of Inflammation, Is Decreased during Simian Immunodeficiency Virus-Associated Central Nervous System Disease

(2013) D. C. Cary et al.   JOURNAL OF IMMUNOLOGY

Alterations in the Levels of Vesicular Trafficking Proteins Involved in HIV Replication in the Brains and CSF of Patients with HIV-associated Neurocognitive Disorders

(2013) Jerel Fields et al.   Journal of Neuroimmune Pharmacology

Expression of Ephrin Receptors and Ligands in Postmortem Brains of HIV-Infected Subjects With and Without Cognitive Impairment

(2013) Vadim Yuferov et al.   Journal of Neuroimmune Pharmacology

Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase

(2013) Alma Sanchez et al.   Journal of Neuroinflammation

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells

(2012) Chieh-Lin Jerry Teng et al.   ANNALS OF HEMATOLOGY

A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

(2012) Mathew P. Martin et al.   CHEMBIOCHEM

Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation

(2012) Crystal Bethel-Brown et al.   Journal of Neuroinflammation

Soluble and Cell-Associated Insulin Receptor Dysfunction Correlates with Severity of HAND in HIV-Infected Women

(2012) Yamil Gerena et al.   PLoS One

Increased CDK5 Expression in HIV Encephalitis Contributes to Neurodegeneration via Tau Phosphorylation and Is Reversed with Roscovitine

(2011) Christina Patrick et al.   AMERICAN JOURNAL OF PATHOLOGY

HIV-1 Tat binds to SH3 domains: Cellular and viral outcome of Tat/Grb2 interaction

(2011) Slava Rom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: Synthesis, neuronal cell culture investigations, and CDK5 docking studies

(2011) Nanditha Nair et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

(2011) Seng Chuan Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy Is Increased in Postmortem Brains of Persons With HIV-1-Associated Encephalitis

(2011) Dejiang Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

(2011) Leslie Crews et al.   Molecular Neurodegeneration

HIV-1-Infected and Immune-Activated Macrophages Induce Astrocytic Differentiation of Human Cortical Neural Progenitor Cells via the STAT3 Pathway

(2011) Hui Peng et al.   PLoS One

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

(2010) Kathryn A. Lindl et al.   Journal of Neuroimmune Pharmacology

Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease

(2010) Myoung-Hwa Lee et al.   NEUROBIOLOGY OF DISEASE

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models

(2010) Bénédicte Menn et al.   PLoS One

Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5

(2009) Joao P. Lopes et al.   AGING CELL

Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions

(2009) G. Cuny   CURRENT PHARMACEUTICAL DESIGN

Molecular Pathology of Neuro-AIDS (CNS-HIV)

(2009) Leslie Crews et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders

(2009) Dawn Eggert et al.   JOURNAL OF NEUROIMMUNOLOGY

Lithium therapy for human immunodeficiency virus type 1–associated neurocognitive impairment

(2009) Giovanni Schifitto et al.   JOURNAL OF NEUROVIROLOGY

Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways

(2009) Suraiya Rasheed et al.   Journal of Translational Medicine

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

(2008) John P. Norman et al.   PLoS One