Heteromultimerization of Cannabinoid CB1Receptor and Orexin OX1Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A

Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia

(2012) Paul J. Coleman et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

The orexin OX1receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands

(2011) Tian-Rui Xu et al.   BIOCHEMICAL JOURNAL

Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis

(2011) T. Voisin et al.   CANCER RESEARCH

A New Perspective of Cannabinoid 1 Receptor Antagonists: Approaches Toward Peripheral CB1R Blockers without Crossing the Blood-Brain Barrier

(2011) Yen-Ku Wu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II

(2011) Raphael Rozenfeld et al.   EMBO JOURNAL

The oligomeric state sets GABABreceptor signalling efficacy

(2011) Laëtitia Comps-Agrar et al.   EMBO JOURNAL

On the Existence of a Possible A2A–D2–β-Arrestin2 Complex: A2A Agonist Modulation of D2 Agonist-Induced β-Arrestin2 Recruitment

(2011) Dasiel O. Borroto-Escuela et al.   JOURNAL OF MOLECULAR BIOLOGY

Heteromerization of the  - and  -Opioid Receptors Produces Ligand-Biased Antagonism and Alters  -Receptor Trafficking

(2011) L. Milan-Lobo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding

(2011) I. Gomes et al.   MOLECULAR PHARMACOLOGY

Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation

(2011) Shao-Qiu He et al.   NEURON

Physical and functional interaction between CB1cannabinoid receptors and β2-adrenoceptors

(2010) Brian D Hudson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ligand-induced internalization of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging

(2010) Richard J Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trans-activation between 7TM domains: implication in heterodimeric GABABreceptor activation

(2010) Carine Monnier et al.   EMBO JOURNAL

Oligomeric Size of the M2Muscarinic Receptor in Live Cells as Determined by Quantitative Fluorescence Resonance Energy Transfer

(2010) Luca F. Pisterzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand Regulation of the Quaternary Organization of Cell Surface M3Muscarinic Acetylcholine Receptors Analyzed by Fluorescence Resonance Energy Transfer (FRET) Imaging and Homogeneous Time-resolved FRET

(2010) Elisa Alvarez-Curto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity

(2010) F. D. Christopoulou et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

(2010) Lin Pei et al.   NATURE MEDICINE

A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain

(2010) Xiao Hong Yu et al.   PAIN

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

(2010) J. A. Hern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor heteromerization and drug discovery

(2010) Raphael Rozenfeld et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Class A GPCR heterodimers: evidence from binding studies

(2010) Nigel J.M. Birdsall   TRENDS IN PHARMACOLOGICAL SCIENCES

Modelling the interdependence between the stoichiometry of receptor oligomerization and ligand binding for a coexisting dimer/tetramer receptor system

(2009) X Rovira et al.   BRITISH JOURNAL OF PHARMACOLOGY

G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

(2009) Graeme Milligan   BRITISH JOURNAL OF PHARMACOLOGY

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors

(2009) Graeme Milligan   CURRENT OPINION IN PHARMACOLOGY

Opioid-receptor-heteromer-specific trafficking and pharmacology

(2009) Richard M van Rijn et al.   CURRENT OPINION IN PHARMACOLOGY

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

(2009) Juan José Fung et al.   EMBO JOURNAL

The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1

(2009) Nicola J. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine A2AReceptor-Antagonist/Dopamine D2Receptor-Agonist Bivalent Ligands as Pharmacological Tools to Detect A2A-D2Receptor Heteromers

(2009) Aroa Soriano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Induced Regulation and Localization of Cannabinoid CB1 and Dopamine D2L Receptor Heterodimers

(2009) J. A. Przybyla et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABABreceptors

(2009) J.-P. Pin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?

(2009) Marta Filizola   LIFE SCIENCES

Ligand- and Heterodimer-Directed Signaling of the CB1 Cannabinoid Receptor

(2009) B. D. Hudson et al.   MOLECULAR PHARMACOLOGY

Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein G o1 by the Ghrelin Receptor

(2009) K. A. Bennett et al.   MOLECULAR PHARMACOLOGY

Determination of supramolecular structure and spatial distribution of protein complexes in living cells

(2009) Valerica Raicu et al.   Nature Photonics

Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the μ-opioid receptor

(2009) H. Schröder et al.   NEUROPHARMACOLOGY

GPCR homomers and heteromers: A better choice as targets for drug development than GPCR monomers?

(2009) Vicent Casadó et al.   PHARMACOLOGY & THERAPEUTICS

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

(2009) Ahmed Hasbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways

(2009) Xavier Rovira et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Physiological relevance of GPCR oligomerization and its impact on drug discovery

(2008) Rosemarie Panetta et al.   DRUG DISCOVERY TODAY

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Constitutive Activity of the Cannabinoid CB1 Receptor Regulates the Function of Co-expressed Mu Opioid Receptors

(2008) Meritxell Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB1 Receptor: Electrophysiological and FRET Assay Analysis

(2008) Minoru Hojo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

(2008) Damien Maurel et al.   NATURE METHODS

Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis

(2008) Daniel Marcellino et al.   NEUROPHARMACOLOGY

G protein-coupled receptor dimers: Functional consequences, disease states and drug targets

(2008) Matthew B. Dalrymple et al.   PHARMACOLOGY & THERAPEUTICS

Hetero-oligomerization of the P2Y11receptor with the P2Y1receptor controls the internalization and ligand selectivity of the P2Y11receptor

(2007) Denise Ecke et al.   BIOCHEMICAL JOURNAL

A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization

(2007) G Milligan   BRITISH JOURNAL OF PHARMACOLOGY

μ opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis

(2006) Carl Rios et al.   BRITISH JOURNAL OF PHARMACOLOGY