Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

(2012) Youridies Vattakuzhi et al.   ARTHRITIS AND RHEUMATISM

Oral apremilast in the treatment of active psoriatic arthritis: Results of a multicenter, randomized, double-blind, placebo-controlled study

(2012) Georg Schett et al.   ARTHRITIS AND RHEUMATISM

Selective PDE inhibitors as novel treatments for respiratory diseases

(2012) Clive P Page et al.   CURRENT OPINION IN PHARMACOLOGY

Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein byStreptococcus pneumoniaeby Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway

(2012) Jiyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial

(2012) Kim Papp et al.   LANCET

The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1

(2012) Riku Korhonen et al.   MOLECULAR IMMUNOLOGY

Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane

(2011) A. Crilly et al.   ANNALS OF THE RHEUMATIC DISEASES

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

(2011) Thérèse Keravis et al.   BRITISH JOURNAL OF PHARMACOLOGY

MAPK Phosphatase-1 (MKP-1) Expression Is Up-Regulated by hCG/cAMP and Modulates Steroidogenesis in MA-10 Leydig Cells

(2011) Laura Brion et al.   ENDOCRINOLOGY

Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates

(2011) Gonghua Huang et al.   IMMUNITY

ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity

(2011) Miki Kobayashi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In Vivo Characterization of GSK256066, a High-Affinity Inhaled Phosphodiesterase 4 Inhibitor

(2011) A. T. Nials et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Attenuation of the acute inflammatory response by dual specificity phosphatase 1 by inhibition of p38 MAP kinase

(2011) Riku Korhonen et al.   MOLECULAR IMMUNOLOGY

Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs

(2010) Riina Nieminen et al.   ARTHRITIS AND RHEUMATISM

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

(2010) Alexander Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids

(2010) F. Li et al.   EUROPEAN RESPIRATORY JOURNAL

Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss

(2010) H Yu et al.   GENE THERAPY

Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma

(2010) S.-L. Catherine Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mitogen-Activated Protein Kinase Phosphatase-1 Negatively Regulates the Expression of Interleukin-6, Interleukin-8, and Cyclooxygenase-2 in A549 Human Lung Epithelial Cells

(2010) T. Turpeinen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids

(2010) Lauren E. Shipp et al.   PLoS One

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

(2010) Fiona E McCann et al.   ARTHRITIS RESEARCH & THERAPY

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis

(2009) PH Schafer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacology of a Novel, Orally Active PDE4 Inhibitor

(2009) Sunanda G. Dastidar et al.   PHARMACOLOGY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

PDE4 inhibitors: current status

(2008) D Spina   BRITISH JOURNAL OF PHARMACOLOGY

Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis

(2008) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Calcineurin inhibitors down-regulate iNOS expression by destabilising mRNA

(2008) Mari Hämäläinen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

(2008) T. Boutros et al.   PHARMACOLOGICAL REVIEWS