Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

Statins for the Prevention and Treatment of Infections

(2009) Imad M. Tleyjeh   ARCHIVES OF INTERNAL MEDICINE

GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation

(2009) Matthijs Kox et al.   BIOCHEMICAL PHARMACOLOGY

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE NOVEL SELECTIVE TOLL-LIKE RECEPTOR 4 SIGNAL TRANSDUCTION INHIBITOR TAK-242 PREVENTS ENDOTOXAEMIA IN CONSCIOUS GUINEA-PIGS

(2009) Masamune Kuno et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Lipopolysaccharide-Trap-Fc, a Multifunctional Agent To Battle Gram-Negative Bacteria

(2009) P. Gross et al.   INFECTION AND IMMUNITY

Effects of Lansoprazole on the Lipopolysaccharide-Stimulated Toll-Like Receptor 4 Signal Transduction Systems: A Study Using the 293hTLR4/MD2-CD14 Cells

(2009) Tadashi Ohara et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis

(2009) Leo Jeng et al.   Journal of Translational Medicine

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1β gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells

(2009) Ta-Liang Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

INHIBITION OF TOLL-LIKE RECEPTOR-4, NUCLEAR FACTOR-κB AND MITOGEN-ACTIVATED PROTEIN KINASE BY LIGNOCAINE MAY INVOLVE VOLTAGE-SENSITIVE SODIUM CHANNELS

(2008) Ping-Ying Lee et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Continuous pharmacodynamic activity of eritoran tetrasodium, a TLR4 antagonist, during intermittent intravenous infusion into normal volunteers

(2008) Daniel P. Rossignol et al.   Innate Immunity

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY

Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression

(2008) Conrad P. Hodgkinson et al.   Pharmacogenetics and Genomics

TLR SIGNALING PATHWAY IN PATIENTS WITH SEPSIS

(2008) Reinaldo Salomão et al.   SHOCK

Opioid-induced immunosuppression

(2008) Paola Sacerdote   Current Opinion in Supportive and Palliative Care

Role of Toll-like receptor responses for sepsis pathogenesis

(2007) Heike Weighardt et al.   IMMUNOBIOLOGY

Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure

(2007) Gábor Földes et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY