Article
Medicine, General & Internal
Courtney D. Dinardo, Harry P. Erba, Sylvie D. Freeman, Andrew H. Wei
Summary: Progress in acute myeloid leukaemia treatment has seen significant improvements in scientific understanding, prognostication tools, risk assessments, and incorporation of measurable residual disease into risk assessments. Recent updates in classification and recommendations by organizations such as WHO, ICC, and European LeukemiaNet have provided enhanced guidance for prognostic stratification and treatment response assessment. There have also been advancements in treatment options, leading to improved outcomes for both newly diagnosed and relapsed patients.
Review
Oncology
Teerna Bhattacharyya, Jonathan Bond
Summary: This review article provides an overview of how genetic alterations in AML affect the structure and function of Polycomb Repressive Complexes (PRCs), particularly focusing on PRC2 core factors. The mutations and deletions in PRC2 factors are linked to other AML-associated genetic alterations and may inform potential treatment avenues. Understanding these genetic interactions and their implications for therapy is crucial in the study of AML.
Article
Hematology
Elena Esperanza-Cebollada, Soledad Gomez-Gonzalez, Sara Perez-Jaume, Nerea Vega-Garcia, Clara Vicente-Garces, Merce Richarte-Franques, Susana Rives, Albert Catala, Montserrat Torrebadell, Mireia Camos
Summary: We established a 24-miRNA signature that predicts the outcome of paediatric acute myeloid leukaemia (AML) by evaluating the role of 89 miRNAs in regulating stemness and combining them with genetics, measurable residual disease (MRD), and stemness-related scores. The 24-miRNA signature was significantly associated with leukaemic stemness scores and patient genetics, and when combined with classical prognostic factors and stemness-related scores, it had a higher predictive capacity for overall and event-free survival in paediatric AML patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Hematology
Sabine Kayser, Mark J. Levis
Summary: Research on the pathogenic mechanisms of AML has made remarkable advances in recent years, especially in the importance of cytogenetic and molecular aberrations. The development of new compounds targeting AML at a molecular level, based on increased understanding of AML pathogenesis facilitated by next-generation sequencing, has turned many hopeful predictions into therapeutic realities.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammed Awal Issah, Dansen Wu, Feng Zhang, Weili Zheng, Yanquan Liu, Rong Chen, Guilan Lai, Jianzhen Shen
Summary: This study investigated the expression profiling of m6A circRNAs in AML and found that circRNA m6A modification may contribute to circRNA regulation in AML.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Jorge Cortes, Carolina Pavlovsky, Susanne Saussele
Summary: Tyrosine-kinase inhibitors have significantly altered the natural course of chronic myeloid leukaemia, allowing some patients to approach a near-normal life expectancy. Successful treatment requires understanding the patient's treatment goals, monitoring optimal response hallmarks, timely interventions, recognition of adverse events, and management of comorbidities.
Review
Immunology
Lifei Liang, Xiaoqing Xu, Jiawei Li, Cheng Yang
Summary: This review summarizes and discusses the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment, revealing the impact of miRNAs and MDSCs on tumor immune escape and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jie Xu, Fan Song, Huijue Lyu, Mikoto Kobayashi, Baozhen Zhang, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Josiah Hiu-yuen Wong, Qixuan Wang, Qi Jin, Qiushi Jin, Yihao Fu, Hongbo Yang, Ross C. Hardison, Sinisa Dovat, Leonidas C. Platanias, Yarui Diao, Yue Yang, Tomoko Yamada, Aaron D. Viny, Ross L. Levine, David Claxton, James R. Broach, Hong Zheng, Feng Yue
Summary: This study uses Hi-C and whole-genome sequencing to analyze samples from AML patients and healthy donors, revealing recurrent and subtype-specific alterations in chromatin structure and loops. Functional validation and manipulation of DNA methylation further highlight the role of repressive loops and hijacked cis elements in AML.
Article
Multidisciplinary Sciences
Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed Salah Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Scott B. Ficarro, Denise Klatt, Christian Brendel, Alessandro Rambaldi, Jerome Ritz, Jarrod A. Marto, Danilo Pellin, Daniel E. Bauer, Scott A. Armstrong, Pietro Genovese
Summary: Epitope engineering of donor haematopoietic stem/progenitor cells endows haematopoietic lineages with selective resistance to CAR T cells or monoclonal antibodies, without affecting protein function or regulation, enabling the targeting of genes that are essential for leukaemia survival and reducing the risk of tumour immune escape.
Review
Hematology
Richard Dillon, Nicola Potter, Sylvie Freeman, Nigel Russell
Summary: Recent years have seen significant advances in the use of molecular diagnostic and monitoring techniques for patients with acute myeloid leukaemia (AML), coupled with the development of new therapeutic agents. This has led to potential improvements in treatment algorithms. The article highlights the importance of molecular monitoring in refining clinical decision-making and personalizing treatment for AML patients, with practical recommendations provided for cases where evidence is lacking or conflicting. Additionally, important technical considerations for clinicians to safely utilize these technologies are reviewed as they become more widely implemented.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Heather A. Ogana, Samantha Hurwitz, Nathan Wei, Eliana Lee, Kayla Morris, Karina Parikh, Yong-Mi Kim
Summary: Acute myeloid leukaemia (AML) has a poor prognosis and new therapeutic strategies are needed. The bone marrow (BM) microenvironment contains niches that interact with both normal haematopoietic stem cells and AML cells. Integrins, which are adhesion molecules in the BM microenvironment, play a central role in AML. AML cells express integrins that bind to ligands in the microenvironment, leading to adhesion, intracellular signalling, and drug resistance. Targeting integrins in AML to disrupt interactions with the microenvironment is being explored as a strategy to overcome drug resistance.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Friederike Pastore, Alessandro Pastore, Maja Rothenberg-Thurley, Klaus H. Metzeler, Bianka Ksienzyk, Stephanie Schneider, Stefan K. Bohlander, Jan Braess, Maria C. Sauerland, Dennis Goerlich, Wolfgang E. Berdel, Bernhard Woermann, Michael S. Von Bergwelt-Baildon, Wolfgang Hiddemann, Karsten Spiekermann
Summary: This study explored the molecular landscape of cytogenetically normal acute myeloid leukemia (CN-AML) with initial hyperleukocytosis and identified several recurrent mutations with prognostic relevance. Although these mutations were present, clinical risk factors remained the predictors for overall survival and relapse-free survival in hyperleukocytotic CN-AML.
Article
Oncology
Angela Gutierrez-Camino, Chantal Richer, Manon Ouimet, Claire Fuchs, Sylvie Langlois, Fida Khater, Maxime Caron, Patrick Beaulieu, Pascal St-Onge, Alain R. Bataille, Daniel Sinnett
Summary: This study conducted comprehensive genomic and transcriptomic analysis of FLT3 in 342 childhood ALL patients, and identified FLT3 mutations and their clinical implications. The study also discovered a novel FLT3 mutation and its impact on treatment response. Furthermore, FLT3 alterations were found to be associated with specific ALL subgroups.
BRITISH JOURNAL OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Xinrong Xiang, Rui Bao, Yu Wu, Youfu Luo
Summary: This article comprehensively reviews the role of mitochondrial proteases in acute myeloid leukemia (AML), highlighting their biological function, chemical modulators, and applicative prospects in AML.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Senol Dogan, Emrulla Spahiu, Anis Cilic
Summary: MicroRNAs (miRNAs) are short non-coding RNAs that play a role in post-transcriptional gene silencing and mRNA regulation. In this study, a structural analysis of 587 miRNAs that are differentially expressed in myeloid cancer was conducted. The study provides insights into the length distribution and nucleotide composition of miRNAs, as well as the identification of frequent motifs in the miRNA dataset. This research contributes to a better understanding of the implications of miRNAs in health and disease.
Article
Biochemistry & Molecular Biology
Valeria Bertagnolo, Silvia Grassilli, Stefano Volinia, Yasamin Al-Qassab, Federica Brugnoli, Federica Vezzali, Elisabetta Lambertini, Maria Palomba, Quirino Piubello, Enrico Orvieto, Cristina Natali, Maria Roberta Piva, Carlo Maria Croce, Silvano Capitani
MOLECULAR CARCINOGENESIS
(2019)
Article
Oncology
Matteo Fassan, Ri Cui, Pierluigi Gasparini, Claudia Mescoli, Vincenza Guzzardo, Caterina Vicentini, Giada Munari, Fotios Loupakis, Sara Lonardi, Chiara Braconi, Marco Scarpa, Edoardo D'Angelo, Salvatore Pucciarelli, Imerio Angriman, Marco Agostini, Renata D'Inca, Fabio Farinati, Roberta Gafa, Giovanni Lanza, Wendy L. Frankel, Carlo Maria Croce, Nicola Valeri, Massimo Rugge
TRANSLATIONAL ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Caterina Vicentini, Federica Calore, Giovanni Nigita, Paolo Fadda, Michele Simbolo, Nicola Sperandio, Claudio Luchini, Rita T. Lawlor, Carlo Maria Croce, Vincenzo Corbo, Matteo Fassan, Aldo Scarpa
BMC GASTROENTEROLOGY
(2020)
Letter
Oncology
Maria Rosaria Sapienza, Fabio Fuligni, Federica Melle, Valentina Tabanelli, Valentina Indio, Maria Antonella Laginestra, Giovanna Motta, Saveria Mazzara, Lorenzo Cerroni, Alessandro Pileri, Fabio Facchetti, Marco Paulli, Luciano Cascione, Alessandro Lagana, Emilio Berti, Manuela Ferracin, Claudio Agostinelli, Elena Sabattini, Carlo Maria Croce, Stefano Aldo Pileri
HEMATOLOGICAL ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Francesca Lovat, Pierluigi Gasparini, Giovanni Nigita, Karilyn Larkin, John C. Byrd, Mark D. Minden, Michael Andreeff, Bing Z. Carter, Carlo M. Croce
Summary: The study found that the loss of both miR-15/16 clusters may act as a potential oncogenic driver in the transition from chronic phase to blast crisis in CML patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Genetics & Heredity
Gerd A. Blobel, Douglas R. Higgs, Jennifer A. Mitchell, Dimple Notani, Richard A. Young
Summary: In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties.
NATURE REVIEWS GENETICS
(2021)
Letter
Multidisciplinary Sciences
Liguo Zhang, Alexsia Richards, M. Inmaculada Barrasa, Stephen H. Hughes, Richard A. Young, Rudolf Jaenisch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Maria Rosaria Sapienza, Giuseppe Benvenuto, Manuela Ferracin, Saveria Mazzara, Fabio Fuligni, Claudio Tripodo, Beatrice Belmonte, Daniele Fanoni, Federica Melle, Giovanna Motta, Valentina Tabanelli, Jessica Consiglio, Vincenzo Mazzara, Marcello Del Corvo, Stefano Fiori, Alessandro Pileri, Gaetano Ivan Dellino, Lorenzo Cerroni, Fabio Facchetti, Emilio Berti, Elena Sabattini, Marco Paulli, Carlo Maria Croce, Stefano A. Pileri
Summary: This study described neuronal features in blastic plasmacytoid dendritic cell neoplasm (BPDCN) for the first time, potentially changing our understanding of the disease and leading to new strategies for treatment. The identified neural metastatic inducers in BPDCN may offer therapeutic approaches for patients. The upregulation of neural genes in BPDCN is currently being investigated as therapeutic targets.
Letter
Multidisciplinary Sciences
Liguo Zhang, Alexsia Richards, M. Inmaculada Barrasa, Stephen H. Hughes, Richard A. Young, Rudolf Jaenisch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Felice Pepe, Laura Z. Rassenti, Yuri Pekarsky, Jadwiga Labanowska, Tatsuya Nakamura, Giovanni Nigita, Thomas J. Kipps, Veronica Balatti, Carlo M. Croce
Summary: Chronic lymphocytic leukemia (CLL) is a common adult leukemia characterized by chromosomal aberrations. This study found that some CLL patients have undetected microdeletions, which are closely associated with chromosomal alterations in cancer. These findings may have clinical relevance for successful stratification of patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Biographical-Item
Oncology
Gary S. Stein, Carlo M. Croce
Article
Oncology
Alessandro La Ferlita, Nipin Sp, Marina Goryunova, Giovanni Nigita, Raphael E. Pollock, Carlo M. Croce, Joal D. Beane
Summary: Soft-tissue sarcomas (STS), a rare and diverse group of tumors, have various subtypes characterized by differences in tumor biology and clinical outcomes. Small non-coding RNAs (sncRNAs), including miRNAs and tRNA-derived ncRNAs, play important roles in STS tumorigenesis and differentiation. However, the translation of these findings into clinical applications, such as biomarkers or therapeutic targets, remains challenging. This review summarizes the current understanding of sncRNAs in STS, with a focus on liposarcoma, and discusses their potential as novel biomarkers and therapeutic targets.
MOLECULAR CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Henry R. Kilgore, Peter G. Mikhael, Kalon J. Overholt, Ann Boija, Nancy M. Hannett, Catherine Van Dongen, Tong Ihn Lee, Young-Tae Chang, Regina Barzilay, Richard A. Young
Summary: This research reveals that different types of intracellular condensates have distinct chemical environments that affect molecular distribution. Machine learning approaches can predict the selective partitioning of molecules in condensates, providing insights for the development of small molecule therapeutics with optimal subcellular distribution and therapeutic benefits.
NATURE CHEMICAL BIOLOGY
(2023)
Meeting Abstract
Oncology
Lucia Casadei, Patricia Sarchet, Luciano Cascione, Giovanni Nigita, Fernanda Costas Casal de Faria, Carlo Maria Croce, Valerie Grignol, Raphael E. Pollock
Meeting Abstract
Oncology
Maria Rosaria Sapienza, Manuela Ferracin, Fabio Fuligni, Federica Melle, Giovanna Motta, Maria Antonella Laginestra, Maura Rossi, Luciano Cascione, Alessandro Lagana, Claudio Agostinelli, Elena Sabattini, Alessandro Pileri, Carlo Maria Croce, Stefano Aldo Pileri
