Article
Immunology
Qi Zhang, Jing Pan, Donghai Xiong, Junjun Zheng, Kristi N. McPherson, Sangbeom Lee, Mofei Huang, Yitian Xu, Shu-hsia Chen, Yian Wang, Lea Hildebrandt Ruiz, Ming You
Summary: Delivery of aerosolized microRNAs targeting PD-L1 can effectively prevent the development and progression of lung cancer. In this study, aerosolized miR-138-5p and miR-200c miRNA mimics were found to inhibit B(a)P-induced lung adenomas and NTCU-induced lung squamous cell carcinomas with no detectable side effects. These miRNAs were also shown to inhibit PD-L1 expression and promote the immune response against cancer cells by increasing CD4+ and CD8+ T cells while reducing PD-1 expression and T-regulatory cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Mei Zhou, Luyao Li, Biyun Chen, Shuya Pan, Wei Tu, Yaxuan Hou, Panpan Chen, Rodolfo Rochin Hernandez, Xue Zhou
Summary: In this study, we found that circ-SHPRH plays a crucial role in cadmium-induced carcinogenesis by regulating miR-224-5p to impact QKI expression, thereby inhibiting the transformation of BEAS-2B cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Gastroenterology & Hepatology
Jie Hong, Fangfang Guo, Shi-Yuan Lu, Chaoqin Shen, Dan Ma, Xinyu Zhang, Yile Xie, Tingting Yan, TaChung Yu, Tiantian Sun, Yun Qian, Ming Zhong, Jinxian Chen, Yanshen Peng, Cheng Wang, Xiang Zhou, Jianjun Liu, Qiang Liu, Xiong Ma, Ying-Xuan Chen, Haoyan Chen, Jing-Yuan Fang
Summary: The study revealed a positive correlation between Fusobacterium nucleatum and high glucose metabolism in patients with colorectal cancer (CRC), suggesting a potential role of gut microbiota in CRC development. Mechanistically, Fusobacterium nucleatum activated the lncRNA ENO1-IT1 pathway to regulate CRC cell glucose metabolism and biological functions. Targeting the ENO1 pathway may have therapeutic implications for CRC patients with elevated Fusobacterium nucleatum levels.
Article
Oncology
Raffaella Liccardo, Raffaele Sessa, Silvia Trombetti, Marina De Rosa, Paola Izzo, Michela Grosso, Francesca Duraturo
Summary: The dysregulation of MMR genes, especially MSH2, plays a crucial role in the pathogenesis of Lynch Syndrome, a hereditary colorectal cancer. MiRNA miR-137 has been identified to regulate MSH2 expression via its 3'UTR region, suggesting a potential mechanism for tumorigenesis in colon cells.
Article
Cell Biology
Jianbin Yin, Hua Zeng, Kai Fan, Haoyu Xie, Yan Shao, Yuheng Lu, Jinjian Zhu, Zihao Yao, Liangliang Liu, Hongbo Zhang, Bingsheng Luo, Xinjie Wang, Chun Zeng, Xiaochun Bai, Haiyan Zhang, Daozhang Cai
Summary: An imbalance in M1/M2 macrophage polarization plays a crucial role in the progression of osteoarthritis (OA). Pentraxin 3 (PTX3) is found to be highly expressed in OA M1-polarized macrophages and is involved in the occurrence and development of OA. PTX3 primarily affects OA through macrophages and the paracrine interaction between macrophages and chondrocytes produces a feedback loop that enhances synovitis and cartilage damage. This study identifies a functional pathway important to OA development and suggests that blocking this pathway and PTX3 may prevent and treat OA.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yuanyuan Shang, Zhe Zhu, Yuanyuan Zhang, Fang Ji, Lian Zhu, Mengcheng Liu, Yewei Deng, Guifen Lv, Dan Li, Zhuqing Zhou, Bing Lu, Chuan-gang Fu
Summary: Resistance to radiotherapy is a major challenge in the treatment of locally advanced rectal cancer. This study investigated the role of a specific microRNA, miR-7-5p, in regulating radioresistance and cancer stem cell (CSC) properties in colorectal cancer (CRC). The findings showed that low miR-7-5p expression was associated with poor prognosis in CRC patients and that overexpression of miR-7-5p could reverse radioresistance and attenuate CSC properties in radioresistant CRC cells. The study also demonstrated that miR-7-5p targeted the stemness-associated transcription factor KLF4 and that delivery of miR-7-5p mimics using magnetic nanoparticles inhibited tumor growth in a mouse model of radioresistant CRC. These findings suggest that miR-7-5p could be a potential target for overcoming resistance to radiotherapy in CRC patients.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Songhua Bei, Qingyu Xu, Fan Li, Chenqu Wu, Qi Sun, Li Feng
Summary: Colorectal cancer is a common and deadly cancer. Treatment often depends on the stage of the disease. Radiotherapy, combined with chemotherapy, is a common intervention, but resistance to radiotherapy poses a challenge. In this study, natural products were screened to identify small molecules that can selectively kill radio-resistant colon cancer cells. Brefeldin A was found to be effective in inducing death in radio-resistant cells through apoptosis and necrosis.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Genetics & Heredity
Fang Jia, Lixia Zhang, Zhengye Jiang, Guowei Tan, Zhanxiang Wang
Summary: This study constructed a ceRNA network related to glioblastoma using multiple databases, and identified FZD1 and KLF10 as potential regulators in glioblastoma.
BMC MEDICAL GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Tian Tian
Summary: In this study, the effects of a new Ag(I)curcuminoid-Gboxin analog complex were investigated using the MCF-7 breast carcinoma cell line. The results showed that Ag(I)FLLL49-GbA could up-regulate the expression of caspase-3, P53, and Bax in MCF-7 cells after 48 hours of treatment. However, it was puzzling because MCF-7 cells do not naturally express caspase-3. Appropriate modifications are suggested to strengthen the findings of this study.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Peng Liao, Wu-hua Huang, Li Cao, Tao Wang, Li-ming Chen
Summary: FOXP2 plays a key role in colorectal cancer (CRC) cell pyroptosis, promoting the activation of caspase-1. Low expression of FOXP2 is associated with poorer prognosis in CRC patients.
Article
Biochemistry & Molecular Biology
Shiori Mori, Rina Fujiwara-Tani, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Kei Goto, Chie Nakashima, Yukiko Nishiguchi, Isao Kawahara, Yi Luo, Hiroki Kuniyasu
Summary: The study shows that enhancing the anti-tumor effect of BCM by suppressing its degradation can suppress the development and progression of colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Marketa Prochazkova, Michael Killinger, Lubomir Prokes, Karel Kleparnik
Summary: Accurate determination of protein levels and changes within individual cells is crucial for understanding physiological events, and single-cell analysis using sensitive instrumentation and methodology is essential for quantifying cellular heterogeneity. The developed method allows for quantifying caspases in individual cells and has potential for investigating non-apoptotic functions of these proteins.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Ryutaro Yasudome, Naohiko Seki, Shunichi Asai, Yusuke Goto, Yoshiaki Kita, Yuto Hozaka, Masumi Wada, Kan Tanabe, Tetsuya Idichi, Shinichiro Mori, Takao Ohtsuka
Summary: In this study, we identified a miRNA, miR-139-3p, that plays a tumor-suppressive role in colorectal cancer (CRC) by inhibiting cancer cell malignant transformation and AKT phosphorylation. Through in silico analysis and gene expression assays, we identified 29 potential targets regulated by miR-139-3p in CRC cells. We also discovered aberrant expression of Keratin 80 (KRT80) in CRC clinical specimens and found that reducing KRT80 expression suppressed CRC cell malignant transformation and AKT phosphorylation. Additionally, the expression of hexokinase-2 (HK2) was reduced in cells with decreased KRT80 or miR-139-3p expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Devin N. Fachko, Yan Chen, Rebecca L. Skalsky
Summary: It has been found that EBV miR-BHRF1-3 can suppress lytic replication by directly inhibiting Zta expression. Moreover, nucleotide variants that impact the function of miR-BHRF1-3 have been identified, which may contribute to specific EBV pathologies.
JOURNAL OF VIROLOGY
(2022)
Article
Cell Biology
Jianjun Zhu, Chunle Zhang, Zhengjie Wang, Lihong Shi, Li Li, Hao Wu, Ming Liu
Summary: miR-138-5p is downregulated in colorectal carcinoma (CRC) and associated with poor prognosis. It suppresses CRC growth and promotes cell death by targeting MCU and promoting mitochondrial biogenesis. Downregulated miR-138-5p strengthens mitochondrial biogenesis and contributes to CRC cell growth.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Jennifer Vazzano, Jewel Tomlinson, Peter P. Stanich, Rachel Pearlman, Matthew F. Kalady, Wei Chen, Heather Hampel, Wendy L. Frankel
Summary: This study examined the utilization of universal tumor screening (UTS) on colorectal cancer (CRC) patients and evaluated the impact of genetic counseling and testing on surgical decisions. The results showed that UTS performed on biopsies provided valuable information for genetic counseling and testing, leading to informed surgical decisions.
Article
Oncology
Andromachi Kotsafti, Matteo Fassan, Francesco Cavallin, Valentina Angerilli, Luca Saadeh, Matteo Cagol, Rita Alfieri, Pierluigi Pilati, Carlo Castoro, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa
Summary: This study found that immune marker expression, oncogene status, and intra- and peritumoral immune infiltrating cells are associated with lymph node metastasis in patients with esophageal adenocarcinoma. These results suggest that immune surveillance failure is the key driver of lymph node metastasis.
Article
Surgery
Vittoria Matilde Piva, Maria Caterina De Grandis, Irene Sole Zuin, Valentina Angerilli, Floriana Nappo, Rita Alfieri, Selma Ahcene Djaballah, Sabina Murgioni, Francesca Bergamo, Matteo Fassan, Michele Valmasoni, Sara Lonardi
Summary: This review summarizes the current evidence on the use of liquid biopsy in gastroesophageal cancer, focusing on the detection of ctDNA in the postoperative setting and its potential role as a guide for treatment decision.
UPDATES IN SURGERY
(2023)
Article
Oncology
Giulia Orsi, Alessandro Cavaliere, Giampaolo Tortora, Sara Lonardi, Marina Macchini, Mariacristina Di Marco, Guido Giordano, Enrico Vasile, Mario Scartozzi, Silvia Bozzarelli, Silvia Noventa, Maria Grazia Rodriquenz, Anna Maria Militello, Ilario Giovanni Rapposelli, Ingrid Garajova, Stefania De Lorenzo, Barbara Merelli, Alessandro Bittoni, Lisa Salvatore, Letizia Procaccio, Chiara Paratore, Andrea Spallanzani, Umberto Peretti, Monica Niger, Elisa Giommoni, Ilaria Bernardini, Emiliano Tamburini, Katia Bernardino, Laura Forti, Maria Maddalena Valente, Stefano Cascinu, Michele Milella, Michele Reni
Summary: This study demonstrates the beneficial role of platinum agents in PDAC patients with gBRCA1-2pv, both in second-line treatment and as part of early 3- and 4-drug platinum-based chemotherapy combinations, providing improved survival outcomes.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Julien Taieb, Sara Lonardi, Jayesh Desai, Gunnar Folprecht, Claire Gallois, Eduardo Polo Marques, Sadya Khan, Claire Castagne, Harpreet Wasan
Summary: The combination of encorafenib and cetuximab is well tolerated in most patients with metastatic colorectal cancer, with the majority of adverse events being mild-to-moderate in severity, occurring early in treatment, and resolving rapidly, except for rare cases of nephrotoxicity.
CLINICAL COLORECTAL CANCER
(2023)
Article
Gastroenterology & Hepatology
Simona Deidda, Gaya Spolverato, Giulia Capelli, Riccardo Quoc Bao, Lorenzo Bettoni, Filippo Crimi, Luigi Zorcolo, Salvatore Pucciarelli, Angelo Restivo
Summary: This study retrospectively reviewed the clinical restaging of rectal cancer after neoadjuvant therapy, and found limitations in accurately detecting the complete pathological response to treatment. Current clinical assessments need to be revised to account for indications for rectal preservation after neoadjuvant chemoradiotherapy.
DISEASES OF THE COLON & RECTUM
(2023)
Correction
Multidisciplinary Sciences
Ludmil B. Alexandrov, Jaegil Kim, Nicholas J. Haradhvala, Mi Ni Huang, Alvin Wei Tian Ng, Yang Wu, Arnoud Boot, Kyle R. Covington, Dmitry A. Gordenin, Erik N. Bergstrom, S. M. Ashiqul Islam, Nuria Lopez-Bigas, Leszek J. Klimczak, John R. McPherson, Sandro Morganella, Radhakrishnan Sabarinathan, David A. Wheeler, Ville Mustonen, Gad Getz, Steven G. Rozen, Michael R. Stratton
Correction
Multidisciplinary Sciences
Claudia Calabrese, Natalie R. Davidson, Deniz Demircioglu, Nuno A. Fonseca, Yao He, Andre Kahles, Kjong-Van Lehmann, Fenglin Liu, Yuichi Shiraishi, Cameron M. Soulette, Lara Urban, Liliana Greger, Siliang Li, Dongbing Liu, Marc D. Perry, Qian Xiang, Fan Zhang, Junjun Zhang, Peter Bailey, Serap Erkek, Katherine A. Hoadley, Yong Hou, Matthew R. Huska, Helena Kilpinen, Jan O. Korbel, Maximillian G. Marin, Julia Markowski, Tannistha Nandi, Qiang Pan-Hammarstrom, Chandra Sekhar Pedamallu, Reiner Siebert, Stefan G. Stark, Hong Su, Patrick Tan, Sebastian M. Waszak, Christina Yung, Shida Zhu, Philip Awadalla, Chad J. Creighton, Matthew Meyerson, B. F. Francis Ouellette, Kui Wu, Huanming Yang, Alvis Brazma, Angela N. Brooks, Jonathan Goeke, Gunnar Raetsch, Roland F. Schwarz, Oliver Stegle, Zemin Zhang
Correction
Multidisciplinary Sciences
Yilong Li, Nicola D. Roberts, Jeremiah A. Wala, Ofer Shapira, Steven E. Schumacher, Kiran Kumar, Ekta Khurana, Sebastian Waszak, Jan O. Korbel, James E. Haber, Marcin Imielinski, Joachim Weischenfeldt, Rameen Beroukhim, Peter J. Campbell
Article
Oncology
Vincenzo Nasca, Francesco Barretta, Francesca Corti, Sara Lonardi, Monica Niger, Maria Elena Elez, Marwan Fakih, Priya Jayachandran, Aakash Tushar Shah, Massimiliano Salati, Elisabetta Fenocchio, Lisa Salvatore, Chiara Cremolini, Javier Ros, Margherita Ambrosini, Giacomo Mazzoli, Rossana Intini, Michael J. Overman, Rosalba Miceli, Filippo Pietrantonio
Summary: In this study of 331 patients with metastatic colorectal cancer treated with immune checkpoint inhibitors, it was found that certain immune-related adverse events (irAEs) could affect patient survival, with some having a protective effect and others having a harmful effect. The study proposed a simple model to evaluate the impact of irAEs on treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Letter
Cell Biology
Andrea Remo, Federica Grillo, Alessandro Vanoli, Paola Parente, Luca Mastracci, Valentina Angerilli, Emanuele Damiano Urso, Francesca Bergamo, Matteo Fassan
Article
Oncology
Floriana Nappo, Lorenzo Fornaro, Luca Pompella, Silvia Catanese, Daniele Lavacchi, Andrea Spallanzani, Alessandro Cappetta, Marco Puzzoni, Sabina Murgioni, Giulia Barsotti, Giuseppe Tirino, Antonio Pellino, Caterina Vivaldi, Antonia Strippoli, Giuseppe Aprile, Samantha Di Donato, Elena Mazza, Michele Prisciandaro, Lorenzo Antonuzzo, Vittorina Zagonel, Stefano Cascinu, Ferdinando De Vita, Sara Lonardi
Summary: This retrospective study on 265 patients treated with FLOT regimen showed that high microsatellite instability (MSI-H) and mismatch repair deficient (dMMR) have a positive prognostic role and better outcome in locally advanced gastric cancer (GC) patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pathology
Federica Zannier, Valentina Angerilli, Gaya Spolverato, Stefano Brignola, Daniele Sandona, Mariangela Balistreri, Marianna Sabbadin, Sara Lonardi, Francesca Bergamo, Claudia Mescoli, Marco Scarpa, Quoc Riccardo Bao, Angelo Paolo Dei Tos, Salvatore Pucciarelli, Emanuele L. D. Urso, Matteo Fassan
Summary: This study aimed to compare the pathological and clinical characteristics of MMR-deficient (MMRd) tumors and MMR proficient (MMRp) cases, with a particular focus on the relationship between these molecular subgroups and lymph node ratio (LNR). The study found significant differences between MMRd and MMRp tumors in terms of sex, age, size, growth pattern, inflammatory infiltrate, perineural invasion, stage, grade, and LNR. In conclusion, MMRd tumors are a distinct molecular subtype of colorectal cancer characterized by a significantly lower LNR, further supporting the prognostic impact of MMRd status in early-stage CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Surgery
Imerio Angriman, Silvia Degasperi, Claudia Mescoli, Carmelo Lacognata, Claudia Armellin, Antonino Caruso, Federico Scognamiglio, Matteo Fassan, Renata D'Inca, Edoardo Savarino, Fabiana Zingone, Gaya Spolverato, Salvatore Pucciarelli, Romeo Bardini, Cesare Ruffolo, Marco Scarpa
Summary: This retrospective study analyzed the intestinal and systemic inflammation after surgery in Crohn's disease patients with strictures where the diseased bowel was left behind. The results showed that the intestinal inflammatory activity decreased even with the preservation of the diseased bowel, but the presence of the diseased bowel increased the risk of reoperation.
Article
Pathology
Denise Gamble, Wendy L. Frankel, Martha M. Yearsley, Wei Chen
Summary: Endoscopic biopsies of the ampulla of Vater are challenging due to sampling limitations and the complexity of local anatomy. A retrospective review of 318 biopsy specimens from 252 patients found that a significant proportion of cases were diagnosed as adenoma or adenocarcinoma. Follow-up specimens showed discordant results in 38.9% of cases, with major discrepancies observed in 22.9% of cases.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)
