Article
Chemistry, Multidisciplinary
Young Hun Chung, Jooneon Park, Hui Cai, Nicole F. Steinmetz
Summary: This study investigates a novel targeted immunotherapy approach using S100A9 as a target, by systemically administering CPMV targeting S100A9 to prevent and treat metastatic diseases from melanoma and breast cancer to the lungs.
Article
Oncology
Ioannis A. Vathiotis, Tyler MacNeil, Jon Zugazagoitia, Konstantinos N. Syrigos, Thazin Nwe Aung, Aaron M. Gruver, Peter Vaillancourt, Ina Hughes, Steve Hinton, Kyla Driscoll, David L. Rimm
Summary: The study revealed that the CD200/CD200R immune checkpoint is widely expressed in lung cancer patients and may serve as a potential target for immune therapy. Both CD200 and CD200R are abundantly expressed in NSCLC patients, with moderate correlation with PD-L1. This finding provides a basis for targeting the CD200/CD200R pathway for treating NSCLC patients.
Review
Oncology
Deborah Choe, Dongwon Choi
Summary: Immune checkpoint molecules function to control and regulate immune response pathways to prevent excessive immune activity from damaging healthy tissues. Targeting these molecules in cancer patients can enhance immune function and restore the natural defense mechanisms against tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Jing Liu, Xixi Ai, Horacio Cabral, Jinlu Liu, Yuan Huang, Peng Mi
Summary: The development of hypoxia-activatable polymeric micelles for tumor-targeted therapy is effective for eradicating advanced breast cancer by triggering synergistic cytotoxicity and immunogenic cell death. These micelles efficiently deliver drugs and photosensitizers to cancer cells, and have the potential to significantly suppress tumor recurrence and metastasis.
Article
Oncology
Tyler MacNeil, Ioannis A. Vathiotis, Saba Shafi, Thazin Nwe Aung, Jon Zugazagoitia, Aaron M. Gruver, Kyla Driscoll, David L. Rimm
Summary: Pancreatic cancer, characterized by a cold tumor microenvironment and limited immunogenicity, presents challenges for immunotherapy. CD8 and FAP show independent predictive value for progression-free and overall survival in PDAC patients. CD200 exhibits heterogeneous expression in PDAC patients, while CD8 and FAP have potential clinical utility.
Article
Immunology
Qin Zhou, Jiawei Xu, Yan Xu, Shaokun Sun, Jian Chen
Summary: The study found that low ICAM1 expression may be related to immune escape, leading to poor treatment response and a worse prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jiafeng Zou, Rui Sun, Muye He, You Chen, Yi Cheng, Chuanhe Xia, Ying Ma, Shulei Zheng, Xiuzhi Fu, Zeting Yuan, Minbo Lan, Kaiyan Lou, Xianjun Chen, Feng Gao
Summary: This study developed an innovative bioactivating drug delivery system that sequentially releases drugs to inhibit platelet activity and treat breast cancer metastasis. In vitro investigations showed that the system effectively suppresses platelet activity, enhances tumor aggregation, and successfully restrains tumor growth and metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Medicinal
Muhammad Luqman Nordin, Ahmad Khusairi Azemi, Abu Hassan Nordin, Walid Nabgan, Pei Yuen Ng, Khatijah Yusoff, Nadiah Abu, Kue Peng Lim, Zainul Amiruddin Zakaria, Noraznawati Ismail, Fazren Azmi
Summary: Breast cancer is the second-leading cancer globally, and immunotherapy via vaccine has gained attention for its specific and targeted immune cell activity against the disease. Peptide-based vaccines, despite their vulnerabilities, can be customized and improved with carriers to induce a specific immune response. Nanotechnology advancements allow the incorporation of other components into peptide-based vaccines, modulating the immune response against breast cancer.
Review
Biochemistry & Molecular Biology
Bojan Stojanovic, Nevena Gajovic, Milena Jurisevic, Milica Dimitrijevic Stojanovic, Marina Jovanovic, Ivan Jovanovic, Bojana S. Stojanovic, Bojan Milosevic
Summary: IL-33 plays a critical role in breast cancer biology, influencing cancer progression and immune response, and may serve as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Yining Zhang, Kevin R. Hughes, Ravi M. Raghani, Jeffrey Ma, Sophia Orbach, Jacqueline S. Jeruss, Lonnie D. Shea
Summary: The study showed that cargo-free PLG nanoparticles can enhance the efficacy of anti-PD-1 immunotherapy by diverting circulating immune cells, reducing immune suppression in the tumor microenvironment. When combined with anti-PD-1 antibody, these nanoparticles significantly slowed tumor growth and provided a survival benefit.
Article
Cell Biology
Gatha Thacker, Samantha Henry, Ajeya Nandi, Rahul Debnath, Snahlata Singh, Anupma Nayak, Barbara Susnik, Melinda M. Boone, Qing Zhang, Susan B. Kesmodel, Sanjeev Gumber, Gokul M. Das, Taku Kambayashi, Camila O. Dos Santos, Rumela Chakrabarti
Summary: Using single-cell RNA sequencing and functional analysis, a unique population of Socs3(high)CD11b(-)CD27(-) immature NK cells was identified in triple-negative breast cancer (TNBC) samples. These NK cells activated cancer stem cells through Wnt signaling, promoting tumor progression. Depletion of NK cells or inhibition of Wnt ligand secretion from NK cells reduced tumor progression. Furthermore, depletion of NK cells or inhibition of their function enhanced the response to anti-PD-L1 antibody or chemotherapy in TNBC mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Xiaoxiao Chen, Jiamei Feng, Weili Chen, Shijun Shao, Li Chen, Hua Wan
Summary: Breast cancer metastasis is a complex process, and breast cancer-derived small extracellular vesicles (sEVs) play a crucial role in the formation of pre-metastatic niches. sEVs contribute to tumor invasion through various mechanisms and can also be used as biomarkers and antimetastatic therapies for breast cancer.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Chemistry, Multidisciplinary
Yamei Liu, Lu Zhang, Rui Chang, Xuehai Yan
Summary: Peptide-based supramolecular PIT nanoagents have been shown to enhance the effect of photoimmunotherapy by utilizing multiple pathways and collaborative strategies to amplify the immune response.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Qingxin Mu, Guanyou Lin, Mike Jeon, Hui Wang, Fei-Chien Chang, Richard A. Revia, John Yu, Miqin Zhang
Summary: This study presents a multifunctional nanoparticle formulation targeting TNBC cells and dendritic cells, inducing tumor apoptosis through multiple mechanisms and significantly inhibiting tumor growth and metastasis while extending survival in a drug-resistant mouse model of TNBC. The promising platform may substantially improve therapeutic efficacy for treating metastatic TNBC.
Review
Oncology
Caroline Boman, Ioannis Zerdes, Kira Martensson, Jonas Bergh, Theodoros Foukakis, Antonios Valachis, Alexios Matikas
Summary: The study found significant discordance in PD-L1 expression between primary and metastatic breast cancer, especially when PD-L1 status is assessed at metastatic sites. Pooled analysis of PD-L1 positivity rates in tumor cells and immune cells showed higher positivity in primary tumors compared to metastasis. Therefore, appropriate tissue sampling is crucial when selecting patients for immunotherapy.
CANCER TREATMENT REVIEWS
(2021)
Article
Oncology
Sayra Dilmac, Nuray Erin, Necdet Demir, Gamze Tanriover
PATHOLOGY & ONCOLOGY RESEARCH
(2018)
Article
Medicine, Research & Experimental
Nuray Erin, Sema Turker, Ozlem Elpek, Bulent Yildirim
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Article
Oncology
Nuray Erin, Nur Ogan, Azmi Yerlikaya
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Correction
Oncology
Nuray Erin, Nur Ogan, Azmi Yerlikaya
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Medicine, Research & Experimental
Esra Nizam, Nuray Erin
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Otorhinolaryngology
Hulya Eyigor, Mete Eyigor, Bekir Erol, Omer Tarik Selcuk, Levent Renda, Mustafa Deniz Yilmaz, Ustun Osma, Cansu Demirkiran, Meral Gultekin, Nuray Erin
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2020)
Article
Pharmacology & Pharmacy
Sule Kale, Aylin F. Korcum, Ertugrul Dundar, Nuray Erin
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Article
Oncology
Nuray Erin, Sayra Dilmac, Anna Curry, Ozlem Duymus, Gamze Tanriover, Aaron Prodeus, Jean Gariepy, Reginald M. Gorczynski
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Review
Oncology
Nuray Erin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Oncology
Esra Nizam, Sadi Koksoy, Nuray Erin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Review
Pharmacology & Pharmacy
Nuray Erin, Jelena Grahovac, Anamaria Brozovic, Thomas Efferth
DRUG RESISTANCE UPDATES
(2020)
Article
Clinical Neurology
Mehmet Akif Kaya, Nuray Erin, Oznur Bozkurt, Nilgun Erkek, Ozgur Duman, Senay Haspolat
Summary: The study found that HMGB1 levels were significantly elevated in the cerebrospinal fluid of children with febrile seizures, while changes in sTLR4 levels were not statistically significant. This suggests that the HMGB1 network may play a role in the occurrence of febrile seizures in children.
Article
Biochemistry & Molecular Biology
Nuray Erin, Esra Tavsan, Ozlem Akdeniz, Vera M. S. Isca, Patricia Rijo
Summary: Activation of CXCR2 by chemokines promotes breast cancer aggressiveness and chemoresistance, but CXCR2 antagonists are being tested in clinical trials. Inhibition of CXCR2 may lead to increased secretion of MIP-2 and KC, which can be prevented by PKC activators. Different PKC activators have varying effects on chemokine secretion and cell proliferation, with PKC delta and PKC epsilon activators showing the most effectiveness in preventing chemoresistance.
Review
Oncology
Christiana M. Neophytou, Ioannis P. Trougakos, Nuray Erin, Panagiotis Papageorgis
Summary: This review discusses the deregulation of apoptotic pathways as a key factor leading to multidrug resistance (MDR) in cancer cells, along with the impact of the tumor microenvironment on apoptosis in MDR tumors. Therapeutic approaches targeting Bcl-2 family members, IAPs, and AKT, as well as the potential of epigenetic modifications in reversing MDR, are highlighted as important strategies against drug resistance.
Article
Surgery
Osman Tolga Harorli, Mukerrem Hatipoglu, Nuray Erin
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2019)