Article
Plant Sciences
Bin Li, Baoke Zhang, Zhenyu Li, Shasha Li, Jun Li, Aiwu Wang, Jinling Hou, Jiping Xu, Rui Zhang
Summary: The study aimed to investigate the potential of ginkgolide C (GC), an active ingredient in Ginkgo biloba leaves, to attenuate cerebral ischemia/reperfusion injury (CI/RI) and its anti-inflammatory effect through suppression of the CD40/NF-kappa B pathway. The results showed that GC reduced neurological scores, cerebral infarct rate, and brain edema, while improving microvessel ultrastructure and blood-brain barrier integrity. GC also inhibited the release of inflammatory mediators and enhanced cell viability. These effects were mediated through the suppression of the CD40/NF-kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Yuming Zhang, Zhen Zhang, Jun Wang, Xiajing Zhang, Jing Zhao, Ning Bai, Annamalai Vijayalakshmi, Qifan Huo
Summary: Scutellarin protects rats from cerebral ischemic injury by inhibiting the inflammatory process through the nuclear factor kappa-B p65 and p38 mitogen-activated protein kinase signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Immunology
Kang Huo, Jing Xu, Meng Wei, Kaige Ma, Jianyi Wang, Jianfeng Han
Summary: Solasonine exhibits neuroprotective effects on cerebral ischemia/reperfusion injury by reducing inflammatory responses, oxidative stress, and neuronal apoptosis, and improving neurological function and neuronal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Yang Yang, Fenglong Zhao, Zhe Yuan, Chuanqiang Wang, Ke Chen, Wenliang Xiao
Summary: miR-218-5p regulates the MEF2C/NF-kappa B axis to alleviate oxidative stress and inflammation in myocardial ischemia-reperfusion injury, reducing myocardial cell damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhimin Li, Xing Cao, Ligen Xiao, Ruijiao Zhou
Summary: The study demonstrated that ALO could alleviate cerebral ischemia/reperfusion injury in rats by activating the PI3K/AKT signaling pathway, reducing oxidative stress, inflammation, and cell apoptosis in a dose-dependent manner.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Medicinal
Xiaobo Dong, Lei Wang, Guangrong Song, Xu Cai, Wenxin Wang, Jiaqi Chen, Gesheng Wang
Summary: The study demonstrates that physcion protects neuronal cells against I/R injury by inhibiting the TLR4/NF-kB pathway, reducing inflammatory response and oxidative stress, and decreasing apoptosis, suggesting a promising therapeutic candidate for ischemic stroke.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Plant Sciences
Hai-Dong Chen, Ming-Zhao Jiang, Ying-Ying Zhao, Xin Li, Hai Lan, Wan-Qi Yang, Yong Lai
Summary: This study discussed the protective effect of Erigeron breviscapus extract (breviscapine) on cerebral ischemia and its possible mechanism by targeting intestinal flora, brain inflammatory pathway, and intestinal CYP3A4. The results indicated that breviscapine could protect rats from cerebral ischemia-reperfusion injury by regulating intestinal flora, inhibiting brain TLR4/MyD88/NF-.B inflammatory pathway, and intestinal CYP3A4 expression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoli Min, Linping Zhao, Ying Shi, Jian Wang, Hongling Lv, Xiaoxiao Song, Qunyuan Zhao, Qing Zhao, Rui Jing, Jiayi Hu
Summary: This study investigates the role of Gomisin J in cerebral ischemia-reperfusion injury and finds that it has anti-apoptotic, antioxidant, and anti-inflammatory effects, reducing the severity of the injury.
Article
Neurosciences
Bingyu Li, Wei Wang, Yanan Li, Su Wang, Hengjuan Liu, Zhongyuan Xia, Wenwei Gao, Bo Zhao
Summary: Activation of NCOA4-mediated ferritinophagy exacerbates early-stage CIRI and plays a crucial role in the progression of oxidative stress, autophagy, and apoptosis. The cGAS-STING pathway is implicated in regulating NCOA4-mediated ferritinophagy, and its inhibition ameliorates CIRI, attenuated by NCOA4 overexpression.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Summary: Berberine exerts neuroprotective effects against ischemic stroke by inhibiting neuronal apoptosis induced by CIRI through downregulating the CNPY2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Fuyuan Li, Qianqian Mao, Jinyu Wang, Xiaoying Zhang, Xinyan Lv, Bo Wu, Tingxu Yan, Ying Jia
Summary: This study investigates the protective mechanism of Salidroside (SAL) on cerebral ischemia reperfusion injury (CIRI) through regulating the Nrf2/Trx1 axis. Results showed that SAL effectively alleviates infarction rate, improves histopathological changes, and reduces apoptosis and oxidative stress in CIRI rats and PC12 cells. It also inhibits ASK1/MAPK and activates Nrf2/Trx1 signaling pathway.
METABOLIC BRAIN DISEASE
(2022)
Article
Immunology
Yahong Fu, Junxian Gao, Yanqing Li, Xi Yang, Yun Zhang
Summary: This study demonstrates the significant role of tripartite motif-containing protein 21 (TRIM21) in cerebral ischemia/reperfusion injury. Inhibition of TRIM21 can alleviate the damage to neurons caused by oxygen-glucose deprivation/reoxygenation (OGD/R). This protective effect may be achieved by regulating the Keap1/Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.