Article
Immunology
Kang Huo, Jing Xu, Meng Wei, Kaige Ma, Jianyi Wang, Jianfeng Han
Summary: Solasonine exhibits neuroprotective effects on cerebral ischemia/reperfusion injury by reducing inflammatory responses, oxidative stress, and neuronal apoptosis, and improving neurological function and neuronal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tao Huang, Junping Yin, Song'e Ren, Xuling Zhang
Summary: The role of KLF4 in CI/R injury and the Nrf2/Trx1 pathway as a downstream pathway of KLF4 in protecting blood-brain barrier after CI/R were investigated. In vivo and in vitro models were established to evaluate the protective role of KLF4 on CI/R and the effect on blood-brain barrier permeability. The results showed that KLF4 exerted a neuroprotective effect through the upregulation of the Nrf2/Trx1 pathway.
Article
Immunology
Qiwen Yu, Sanyang Chen, Hongwei Tang, Xiaodan Zhang, Ruolin Tao, Zhiping Yan, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Summary: Veratric acid (VA) has protective effects against liver ischemia/reperfusion (I/R) injury by activating the Nrf2 signaling pathway, leading to increased expression of Nrf2, HO-1, and NQO-1 proteins, which helps alleviate oxidative stress and apoptosis, thus reducing liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao
Summary: Stroke is a major cause of death, with oxidative stress playing a key role. Celastrol has strong antioxidant properties, but its effect on oxidative reactions in cerebral ischemic-reperfusion injury (CIRI) is unclear. This study aimed to investigate the impact of celastrol on oxidative damage during CIRI and the underlying mechanisms. The findings revealed that celastrol reduced oxidative injury in CIRI by upregulating Nrf2. Celastrol directly bound to Nedd4, releasing Nrf2 in astrocytes, thus inhibiting Nrf2 degradation and reducing astrocytic ROS production. Celastrol also rescued neurons from damage and apoptosis by inhibiting oxidative stress and astrocyte activation.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Plant Sciences
Xiaoqi Zhao, Yutong Liu, Lei Wang, Chaolong Yan, Han Liu, Wenxin Zhang, Hongting Zhao, Chen Cheng, Zhipeng Chen, Tianze Xu, Kuanyu Li, Jing Cai, Tong Qiao
Summary: Oridonin exhibits a protective effect on hindlimb ischemia-reperfusion injury, possibly through Nrf2-mediated oxidative stress and NLRP3-mediated inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yun Wang, Zhe Chen, Jing Luo, Jing Zhang, A-ming Sang, Zhen-shun Cheng, Xin-yi Li
Summary: This study demonstrates that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Letter
Neurosciences
Shitao Lv, Haiyan Yang, Pengcheng Jing, Haiying Song
Summary: Alpha-tocopherol has shown antioxidant, anti-inflammatory, and anti-apoptotic abilities in rat brain tissue, mitigating nerve damage caused by cerebral ischemia-reperfusion injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Yahong Fu, Junxian Gao, Yanqing Li, Xi Yang, Yun Zhang
Summary: This study demonstrates the significant role of tripartite motif-containing protein 21 (TRIM21) in cerebral ischemia/reperfusion injury. Inhibition of TRIM21 can alleviate the damage to neurons caused by oxygen-glucose deprivation/reoxygenation (OGD/R). This protective effect may be achieved by regulating the Keap1/Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhimin Li, Xing Cao, Ligen Xiao, Ruijiao Zhou
Summary: The study demonstrated that ALO could alleviate cerebral ischemia/reperfusion injury in rats by activating the PI3K/AKT signaling pathway, reducing oxidative stress, inflammation, and cell apoptosis in a dose-dependent manner.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xueheng Xie, Fan Wang, Wenxiu Ge, Xiangbao Meng, Lijuan Fan, Wei Zhang, Zhen Wang, Meng Ding, Shengliang Gu, Xiaoyan Xing, Xiaobo Sun
Summary: Scu exhibits antioxidant, anti-inflammatory, and neuroprotective effects in CIRI through Nrf2 activation mediated by the PI3K/Akt pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Fei Zhu, Jianzhong Xiong, Fei Yi, Ermin Luo, Chun Huang, Runying Li
Summary: The aim of the study was to investigate the functions of the natural compound Albiflorin (AF) in cerebral ischemia-reperfusion (IR) injury. The researchers used in vitro and in vivo models to show that AF treatment reduced cell apoptosis, decreased inflammatory cytokine levels, and mitigated oxidative stress induced by IR injury. The study also demonstrated that AF activated the Nrf2/HO-1 pathway to alleviate cerebral IR injury.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qianqian Zhang, Min Yao, Jiajia Qi, Rui Song, Lei Wang, Jiacheng Li, Xian Zhou, Dennis Chang, Qi Huang, Lili Li, Ning Wang
Summary: The natural compound Puerarin (PUE) has a therapeutic effect on cerebral ischemia-reperfusion injury by inhibiting oxidative stress related to the PI3K/Akt/Nrf2 pathway. Experimental results showed that PUE could improve neurological deficits in rats and reduce oxidative stress levels.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Surgery
Tianzhu Tao, Bo Ye, Yuhai Xu, Yi Wang, Ying Zhu, Ye Tian
Summary: In this study, the protective effects of beta-patchoulene (beta-PAE) on hepatic ischemia-reperfusion (I/R) injury were investigated. The results demonstrated that beta-PAE could alleviate tissue damage and inflammation induced by hepatic I/R injury, and it exerted its effects by modulating the balance between Nrf2/HO-1 and NF-kappa B pathways.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Behavioral Sciences
Zhe Xue, Kai Zhao, Zhenghui Sun, Chen Wu, Bowen Yu, Dongsheng Kong, Bainan Xu
Summary: Isorhapontigenin (ISO) has shown significant antioxidant effects in reducing oxidative damage induced by cerebral ischemia/reperfusion injury. Its neuroprotective mechanism may be related to the activation of the PKC epsilon/Nrf2/HO-1 signaling pathway.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Chun Chu, Xiang Gao, Xiang Li, Xiaoying Zhang, Ruixin Ma, Ying Jia, Dahong Li, Dongkai Wang, Fanxing Xu
BIOMOLECULES & THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Xiaoying Zhang, Jinyu Wang, Guowei Gong, Ruixin Ma, Fanxing Xu, Tingxu Yan, Bo Wu, Ying Jia
BIOMOLECULES & THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Jinyu Wang, Xiaoying Zhang, Luxin Zhang, Tingxu Yan, Bo Wu, Fanxing Xu, Ying Jia
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Plant Sciences
Mengjie Xu, Jinyu Wang, Xiaoying Zhang, Tingxu Yan, Bo Wu, Kaishun Bi, Ying Jia
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Fanxing Xu, Xiaoying Zhang, Jinyu Wang, Xu Li, Bosai He, Feng Xiao, Tingxu Yan, Bo Wu, Ying Jia, Zhenzhong Wang
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2020)
Article
Chemistry, Medicinal
Wei-Lin Xiong, Yu Sun, Tian-Cheng Ma, Xiao-Ying Zhang, Jin-Yu Wang, Yi-Yang Du, Bo Wu, Ting-Xu Yan, Ying Jia
Summary: A pair of differential epimers with opposite C-7 configurations and their unique glycoside structures were isolated and identified from the succulent stem of Cistanche tubulosa. The inhibitory effects of these compounds on lipopolysaccharide-induced nitric oxide production in mouse microglial cells were tested.
Article
Plant Sciences
Wenjuan Liu, Xiaoying Zhang, Tiancheng Ma, Jinyu Wang, Xinyan Lv, Bo Wu, Tingxu Yan, Ying Jia
Summary: The pharmacological mechanisms of Wei-Tong-Xin (WTX) in treating gastric ulcers (GU) were explored using network pharmacology and in vivo experiments. The study revealed that WTX may regulate the PI3K/AKT signaling pathway and related gene targets to affect the inflammatory response and apoptosis process, making it an effective drug candidate for modern GU treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaoying Zhang, Wenjuan Liu, Shuanglin Zhang, Jinyu Wang, Xihan Yang, Ruixuan Wang, Tingxu Yan, Bo Wu, Yiyang Du, Ying Jia
Summary: This study first reported the chemical profile of Wei-Tong-Xin (WTX) and revealed that WTX inhibited the occurrence of gastric antral inflammation and improved functional dyspepsia (FD) symptoms induced by chemotherapy drug cisplatin (CIS) by remodeling the gut microbiota structure and adjusting the levels of metabolites.
Article
Chemistry, Analytical
Xinyan Lv, Qinghua Xu, Zhiqin Zhang, Jinyu Wang, Meiqi Wan, Xiaoying Zhang, Bo Wu, Tingxu Yan, Ying Jia
Summary: Using high-performance liquid chromatography-quadrupole-time of flight/mass spectrometry and network pharmacology, this study identified the active components and mechanism-based biomarkers of Geng-Nian-Shu in treating perimenopausal syndrome. The PhosphoInositide-3 Kinase/Akt pathway was found to be the main regulatory pathway for Geng-Nian-Shu treatment. Potential biomarkers associated with Geng-Nian-Shu treatment of ovariectomy-induced perimenopausal syndrome were identified using correlation analysis with plasma estrogen levels.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Food Science & Technology
Tiancheng Ma, Yu Sun, Junpeng Lin, Jinyu Wang, Xiaoying Zhang, Tingxu Yan, Ying Jia
Summary: In this study, 21 compounds were obtained from the flower buds of Hemerocallis citrina, including three novel compounds. Compounds 1, 2, 3, 4, 5, 7, and 13 showed significant inhibition of NO in LPS-induced BV2 cells. Molecular docking analysis indicated that compound 1 may have anti-neuroinflammatory effects through the MAPK signaling pathway. Pharmacological experiments confirmed that compound 1 effectively inhibited the generation of NO and inflammatory cytokines by inhibiting the activation of MAPK and NF-kappa B pathway. This research provides a basis for further exploring and utilizing the anti-neuroinflammatory effects of Hemerocallis citrina.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Pharmacology & Pharmacy
Meiqi Wan, Jun Dai, Anna Gan, Jinyu Wang, Fei Lin, Xiaoying Zhang, Xinyan Lv, Bo Wu, Tingxu Yan, Ying Jia
Summary: This study predicted the mechanism of Dehydrocostus lactone (DHE) in treating gastric cancer (GC) through network pharmacology and verified the prediction through in vitro experiments. The results showed that DHE inhibited the growth and metastasis of GC cells and suppressed key signaling pathways related to apoptosis and epithelial-mesenchymal transition. These findings suggest that DHE is a potential natural chemotherapeutic drug for GC treatment.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengjie Xu, Xiaoying Zhang, Fangyi Ren, Tingxu Yan, Bo Wu, Kaishun Bi, Wenchuan Bi, Ying Jia