Article
Medicine, Research & Experimental
Shan Dongjie, R. Samuel Rajendran, Qing Xia, Gaimei She, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: The neuroprotective effects of Tongtian Oral Liquid (TTKFY) were evaluated in an animal model of Parkinson's disease. The results showed that TTKFY protected dopaminergic neurons, improved behavioral function, increased antioxidant activities, and regulated gene expression. This suggests that TTKFY has potential in preventing and treating Parkinson's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Sai Teja Meka, Sree Lalitha Bojja, Gautam Kumar, Sumit Raosaheb Birangal, Mallikarjuna Rao
Summary: Parkinson's Disease (PD) is a rapidly growing neurological disorder with high disability and mortality rates. Current treatments focus on symptomatic relief but there is a need for disease-modifying therapies. Recent research has identified histone deacetylase inhibitors (HDACi) as potential drug targets for neurodegenerative diseases like PD. A study found that a novel pan-HDACi showed neuroprotective effects in a PD rat model by reducing oxidative stress and inflammation, and restoring dopamine levels in the striatum.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sandro Huenchuguala, Juan Segura-Aguilar
Summary: Iron plays a fundamental role in various aspects of human life, but an imbalance in iron levels can lead to certain pathologies. Maintaining iron homeostasis is crucial in preventing these pathologies. While there is evidence suggesting iron's involvement in the degenerative process of Parkinson's disease, clinical studies have not shown positive effects of iron chelators in treating the disease.
Review
Neurosciences
Francisco Nieto-Escamez, Esteban Obrero-Gaitan, Irene Cortes-Perez
Summary: Non-motor symptoms in Parkinson's disease (PD) include ocular, visuoperceptive, and visuospatial impairments. Ocular impairments affect vision and eye movement, while visuoperceptive impairments involve difficulties perceiving visual stimuli accurately and visuospatial impairments affect spatial relationships and judgement. PD patients also face attention and perceptual disturbances with visual stimuli. The neurobiological bases of visual-related disorders in PD are complex and not fully understood, with changes in cortical and subcortical regions and alterations in dopamine, acetylcholine, and serotonin systems potentially involved.
Article
Biochemistry & Molecular Biology
Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Seo
Summary: The anti-diabetic drug vildagliptin has been found to have protective effects against motor dysfunction caused by Parkinson's disease (PD), potentially through the regulation of PI3k/Akt, ERK, and JNK signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luca Magistrelli, Marco Ferrari, Alessia Furgiuele, Anna Vera Milner, Elena Contaldi, Cristoforo Comi, Marco Cosentino, Franca Marino
Summary: Parkinson's disease is a neurodegenerative disorder caused by loss of dopaminergic neurons. Treatment relies on dopaminergic replacement, but genetic factors can influence the clinical progression and drug response in patients. Understanding the genetic variability of dopaminergic receptors may provide insights into the development of personalized therapies for PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sandra Duperrier, Analia Bortolozzi, Veronique Sgambato
Summary: Parkinson's disease (PD) is characterized by cell loss in the substantia nigra and the presence of alpha-synuclein-containing neuronal Lewy bodies. This study investigated the expression levels of alpha-, beta-, and gamma-synucleins in brainstem regions involved in PD physiopathology. The results showed increased expression of these synucleins in the PD model macaques, which correlated with cell loss and motor score.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Manuj Ahuja, Navneet Ammal Kaidery, Otis C. Attucks, Erin McDade, Dmitry M. Hushpulian, Arsen Gaisin, Irina Gaisina, Young Hoon Ahn, Sergey Nikulin, Andrey Poloznikov, Irina Gazaryan, Masayuki Yamamoto, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Research suggests that genetic deletion or pharmacologic inhibition of Bach1 could be a promising therapeutic approach for Parkinson's disease, offering neuroprotection and reducing oxidative damage and neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Alexander Kim, Ekaterina Pavlova, Anna Kolacheva, Vsevolod Bogdanov, Liliya Dilmukhametova, Viktor Blokhin, Lev Valuev, Ivan Valuev, Marina Gorshkova, Michael Ugrumov
Summary: The fight against neurodegenerative diseases, including Parkinson's disease (PD), is a global challenge. This study aims to develop an early diagnosis of PD using an intranasal provocative test on animal models.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Behavioral Sciences
M. F. L. Ruitenberg, N. C. van Wouwe, S. A. Wylie, E. L. Abrahamse
Summary: Dopamine plays a specific role in action control in Parkinson's disease patients, with the expression of medication effects depending on patient characteristics and the experimental tasks used. Future research should employ multi-method approaches and within-subject comparisons to investigate the effects of dopamine on different action control components and underlying striatal pathways.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Clinical Neurology
Ryan Wang, Ludy C. Shih
Summary: The purpose of this review is to evaluate recent studies on the treatment of motor and non-motor symptoms in Parkinson's disease (PD) and their impact. New formulations of levodopa provide better control of motor fluctuations and reduce dyskinesia. On demand apomorphine is an effective and tolerable tool for treating motor off-periods. Promising preliminary data suggest new agents for non-motor symptoms like constipation and sleep disorders. Expiratory muscle strength training may effectively alleviate oropharyngeal dysphagia associated with PD. Using shorter pulse width and directional deep brain stimulation leads can enhance therapeutic outcomes in PD.
CURRENT OPINION IN NEUROLOGY
(2023)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Geriatrics & Gerontology
Maria G. Grammatikopoulou, Georgios Tousinas, Chrysanthi Balodimou, Dimitrios A. Anastasilakis, Konstantinos Gkiouras, Efthimios Dardiotis, Athanasios E. Evangeliou, Dimitrios P. Bogdanos, Dimitrios G. Goulis
Summary: The efficacy of ketogenic therapy in Parkinson's disease remains inconclusive, with heterogeneous results from human RCTs and more promising results from animal studies. Further research is needed to evaluate the effect of ketogenic therapy in PD.
Article
Plant Sciences
Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen
Summary: In this study, a natural compound called morin was found to promote mitophagy and have therapeutic effects on a Parkinson's disease mouse model. Morin acts by activating the AMPK-ULK1 pathway and promoting nuclear translocation of the mitophagy regulator TFEB. This research lays the foundation for the potential use of morin as a clinical drug for Parkinson's disease treatment.
Review
Cell Biology
P. A. Dionisio, J. D. Amaral, C. M. P. Rodrigues
Summary: Parkinson's disease is the second most common neurodegenerative disease globally, typically associated with dopaminergic damage. The main physiological characteristics that make the nigrostriatal circuit more susceptible to mitochondrial dysfunction and oxidative stress are related to several cell death mechanisms, including apoptosis, necrosis, and ferroptosis.
AGEING RESEARCH REVIEWS
(2021)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.