A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells

Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice

(2013) Xiao Yun Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Inhibition of HSP90 molecular chaperones: moving into the clinic

(2013) Rocio Garcia-Carbonero et al.   LANCET ONCOLOGY

Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones

(2012) Manja Zec et al.   Anti-Cancer Agents in Medicinal Chemistry

HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells

(2012) B. Newman et al.   CANCER RESEARCH

The essential role of PIM kinases in sarcoma growth and bone invasion

(2012) M. Narlik-Grassow et al.   CARCINOGENESIS

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy

(2012) Carmen Sanmartín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo

(2012) David B. Lovejoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Activity of Metal Complexes: Involvement of Redox Processes

(2011) Ute Jungwirth et al.   ANTIOXIDANTS & REDOX SIGNALING

SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells

(2011) Kai-Sheng Liu et al.   CANCER LETTERS

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway

(2011) Tatjana Srdić-Rajić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Copper complexes as therapeutic agents

(2011) Clare Duncan et al.   Metallomics

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18

(2010) Songhai Tian et al.   Autophagy

17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

(2010) Panagiotis K Karkoulis et al.   BMC CANCER

A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo

(2010) Chad N. Hancock et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide

(2010) Snežana Bjelogrlić et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

(2009) Jennifer K. McCleese et al.   INTERNATIONAL JOURNAL OF CANCER

Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death

(2008) Raphael Beck et al.   BIOCHEMICAL PHARMACOLOGY

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

(2008) Y. Okawa et al.   BLOOD

Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones

(2008) Nevenka Gligorijević et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY