Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK

Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy

(2014) A. Duckworth et al.   BLOOD

The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy

(2014) G. Packham et al.   HAEMATOLOGICA

Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

(2014) Chih-Hang Anthony Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Pathogenesis of Chronic Lymphocytic Leukemia

(2013) Suping Zhang et al.   Annual Review of Pathology-Mechanisms of Disease

Targeting B-cell anergy in chronic lymphocytic leukemia

(2013) B. Apollonio et al.   BLOOD

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

(2013) V. Coelho et al.   BLOOD

Identification of endoplasmic reticulum stress-inducing agents by antagonizing autophagy: a new potential strategy for identification of anti-cancer therapeutics in B-cell malignancies

(2013) Emilia Mahoney et al.   LEUKEMIA & LYMPHOMA

IgD cross-linking induces gene expression profiling changes and enhances apoptosis in chronic lymphocytic leukemia cells

(2013) Simona Tavolaro et al.   LEUKEMIA RESEARCH

Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma

(2013) L. Vincenz et al.   MOLECULAR CANCER THERAPEUTICS

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

(2013) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice

(2012) C. L. Kriss et al.   BLOOD

The B-cell receptor signaling pathway as a therapeutic target in CLL

(2012) J. A. Woyach et al.   BLOOD

DangER: protein ovERload. Targeting protein degradation to treat myeloma

(2012) L. I. Aronson et al.   HAEMATOLOGICA

Cellular origin and pathophysiology of chronic lymphocytic leukemia

(2012) Marc Seifert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Expression of the Endoplasmic Reticulum Stress Sensor BiP/GRP78 Predicts Response to Chemotherapy and Determines the Efficacy of Proteasome Inhibitors in Diffuse Large B-Cell Lymphoma

(2011) Ana Mozos et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia

(2011) A. Paterson et al.   BLOOD

Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells

(2011) S. Krysov et al.   BLOOD

B-cell receptor signaling in chronic lymphocytic leukemia

(2011) F. K. Stevenson et al.   BLOOD

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(2011) Carlo Calissano et al.   MOLECULAR MEDICINE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL

(2010) E. Rosati et al.   BLOOD

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia

(2010) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL

(2009) F. Forconi et al.   BLOOD

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

(2009) Chih-Chi Andrew Hu et al.   EMBO JOURNAL

Expression pattern of XBP1(S) in human B-cell lymphomas

(2009) L. Maestre et al.   HAEMATOLOGICA

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

(2009) Silvia Masciarelli et al.   MOLECULAR IMMUNOLOGY

T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability

(2008) Shinichi Takano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

(2008) C. Pepper et al.   BLOOD

Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

(2008) M. Muzio et al.   BLOOD