Article
Medicine, Research & Experimental
Zhangdi Xu, Bihui Pan, Yi Miao, Yue Li, Shuchao Qin, Jinhua Liang, Yilin Kong, Xinyu Zhang, Jing Tang, Yi Xia, Huayuan Zhu, Li Wang, Jianyong Li, Jiazhu Wu, Wei Xu
Summary: This study aimed to investigate the prognostic role of XPO1 and the therapeutic effect of Selinexor in chronic lymphocytic leukemia (CLL). The results showed that XPO1 was highly expressed in CLL patients and was associated with poor prognosis. Selinexor, an inhibitor of XPO1, induced apoptosis in CLL cells and had inhibitory effects on cell proliferation and cell cycle progression. Downregulation of NF-kappa B and FOXO pathways was observed in CLL cells treated with Selinexor.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Michele Fiore, Michele Mosconi, Francesco Boni, Alice Parodi, Annalisa Salis, Bruno Tasso, Eloise Mastrangelo, Enrico Millo, Federica Cossu
Summary: Inhibitor of Apoptosis Proteins (IAPs) are important targets for cancer therapy, but their activity regulation within the NF-kappa B pathway can cause chemoresistance. The molecule FC2 was found to modulate the NF-kappa B pathway in MDA-MB-231 adenocarcinoma cancer cells. FC2 combined with Smac-mimetics or TNF showed improved cytotoxic effects. The study also proposed 22 derivatives of FC2 with modified structures and evaluated their efficacy/potency in cells and binding affinity to the target proteins.
Article
Biochemistry & Molecular Biology
Joong-Seok Woo, Eun-Seon Yoo, Sung-Hyun Kim, Jae-Han Lee, So-Hee Han, Soo-Hyun Jung, Gi-Hwan Jung, Ji-Youn Jung
Summary: OA treatment leads to induction of apoptosis in melanoma cells through increased apoptotic bodies and decreased expression of antiapoptotic proteins such as Bcl-2.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Byeongho Jung, Gerardo Ferrer, Pui Yan Chiu, Rukhsana Aslam, Anita Ng, Florencia Palacios, Michael Wysota, Martina Cardillo, Jonathan E. Kolitz, Steven L. Allen, Jacqueline C. Barrientos, Kanti R. Rai, Nicholas Chiorazzi, Barbara Sherry
Summary: Chronic lymphocytic leukemia (CLL) patients with higher levels of IL-17A(+) and IL-17F(+) CD4(+) T cells and increased expression of miR155 in Th17 cells have better outcomes. CLL cells directly regulate miR155 levels in T cells, thereby affecting Th17 differentiation. CLL cells promote IL-17A(+) and IL-17F(+) T cell generation through an miR155-dependent mechanism. This mechanism is associated with clinical prognosis in CLL.
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Medicine, Research & Experimental
Mingkwan Na Takuathung, Saranyapin Potikanond, Siriwoot Sookkhee, Pitchaya Mungkornasawakul, Thanathorn Jearanaikulvanich, Kittinan Chinda, Nitwara Wikan, Wutigri Nimlamool
Summary: The study demonstrated that Kaempferia parviflora extract has significant anti-inflammatory and anti-psoriatic effects by suppressing key inflammatory markers and inhibiting NF-kappa B pathway activation and protein phosphorylation. The results suggest that KP extract has potential as a promising agent for treating inflammation and psoriasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Eiichi Kusagawa, Chiharu Okuda, Rikako Yamaguchi, Kaori Nakano, Yasunobu Miyake, Takao Kataoka
Summary: Cucurbitacin B down-regulates TNF-alpha-induced ICAM-1 expression and inhibits the inflammatory response in lung adenocarcinoma cells by modulating the TNF-R1 expression in the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bo Ke, Anna Li, Huan Fu, Chunfang Kong, Tingting Liu, Qingqing Zhu, Yue Zhang, Zixia Zhang, Chen Chen, Chenghao Jin
Summary: Recent studies have shown that overexpression of PARP-1 may represent an important risk factor in AML patients. The PARP-1 inhibitor Olaparib can enhance the chemosensitivity of leukemia cells to IDA by decreasing the DNA damage response and attenuating the NF-kappa B pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Pei-Wei Weng, Vijesh Kumar Yadav, Narpati Wesa Pikatan, Iat-Hang Fong, I-Hsin Lin, Chi-Tai Yeh, Wei-Hwa Lee
Summary: Our research demonstrated that in osteoarthritis, activated human chondrocytes (AC) show elevated expression of NF kappa B, TNF-alpha, IL-6, and miR-21 compared to healthy chondrocytes (HC). AC induced apoptosis in HC and inhibited the expression of chondrogenesis inducers. The study revealed the role of the NF kappa B/miR-21 axis in OA progression, and the therapeutic potential of SC75741 as an inhibitor of miR-21/NF kappa B-driven OA progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Yu Zhang, Zhuo-Chang Chen, Nan Li, Zhi-Hua Wang, Ya-Li Guo, Cui-Jie Tian, Dong-Jun Cheng, Xue-Yi Tang, Luo-Xian Zhang
Summary: Activated neutrophil-derived CRNDE is transferred to ASMCs through exosomes, activating the NF-kappa B pathway and promoting the proliferation and migration of ASMCs, which contributes to airway remodeling in asthma.
HUMAN MOLECULAR GENETICS
(2022)
Article
Gastroenterology & Hepatology
Yue Feng, Haibo Dong, Bo Sun, Yun Hu, Yang Yang, Yimin Jia, Longfei Jia, Xiang Zhong, Ruqian Zhao
Summary: The study revealed the close association between m(6)A methylation, METTL3/METTL14 upregulation, and TGF-beta 1 upregulation in NASH rat liver and LPS-activated KCs. NF-kappa B acts as a transcription factor to transactivate METTL3/METTL14 genes, leading to global RNA m(6)A hypermethylation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Cell Biology
Magdalena Kopytek, Michal Zabczyk, Piotr Mazur, Anetta Undas, Joanna Natorska
Summary: This study aimed to investigate the effect of LDL cholesterol on plasminogen activator inhibitor 1 (PAI-1) expression in aortic stenosis (AS). Results showed that PAI-1 expression in stenotic valves was correlated with lipid accumulation and AS severity, and co-expressed with nuclear factor-κB (NF-κB). In vitro experiments demonstrated that LDL stimulation increased PAI-1 levels and prolonged clot lysis time (CLT). Inhibition of PAI-1 activity or NF-κB pathway shortened CLT. These findings suggest that valvular PAI-1 overexpression driven by lipid accumulation contributes to hypofibrinolysis and AS severity in severe AS patients.
Article
Biochemistry & Molecular Biology
Min Jeong Kim, Dae Won Kim, Ju Gyeong Kim, Youngjae Shin, Sung Keun Jung, Young-Jun Kim
Summary: Pink pepper demonstrates higher antioxidant effects and contains richer phenolic substances, showing significant effects in suppressing inflammation and oxidative stress.
Article
Biochemistry & Molecular Biology
Britta Marko, Paulina Heurich, Patrick Thon, Frieda Zimmer, Lars Bergmann, Hartmuth Nowak, Katharina Rump, Bjorn Koos, Michael Adamzik, Matthias Unterberg, Tim Rahmel
Summary: The NF-kappa B1 promoter polymorphism (-94ins/delATTG) is functionally important and plays a significant role in inflammation and sepsis. This study found that individuals with the deletion allele of this polymorphism exhibited lower nuclear activity of subunit p50, leading to aggravated inflammation and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Oncology
Vaibhav Sahai, Kent A. Griffith, Bruce Shih-Li Lin, Heloisa P. Soares, Sreenivasa R. Chandana, Oxana V. Crysler, Thomas Enzler, Mark Zalupski
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jaffer A. Ajani, Thomas A. D'Amico, David J. Bentrem, Joseph Chao, David Cooke, Carlos Corvera, Prajnan Das, Peter C. Enzinger, Thomas Enzler, Paul Fanta, Farhood Farjah, Hans Gerdes, Michael K. Gibson, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Rajesh N. Keswani, Sunnie Kim, Lawrence R. Kleinberg, Samuel J. Klempner, Jill Lacy, Quan P. Ly, Kristina A. Matkowskyj, Michael McNamara, Mary F. Mulcahy, Darryl Outlaw, Haeseong Park, Kyle A. Perry, Jose Pimiento, George A. Poultsides, Scott Reznik, Robert E. Roses, Vivian E. Strong, Stacey Su, Hanlin L. Wang, Georgia Wiesner, Christopher G. Willett, Danny Yakoub, Harry Yoon, Nicole McMillian, Lenora A. Pluchino
Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, with over 95% being adenocarcinomas. It is often diagnosed at an advanced stage, leading to a poor prognosis. However, systemic therapy can alleviate symptoms, improve survival, and enhance quality of life. The implementation of biomarker testing has significantly impacted clinical practice and patient care. Targeted therapies have shown encouraging results in clinical trials. Palliative management is recommended for patients with unresectable or metastatic cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Yijiang Shi, Fumou Sun, Yan Cheng, Brent Holmes, Binod Dhakal, Joseph F. Gera, Siegfried Janz, Alan Lichtenstein
Summary: This study investigates the role of A1-dependent myc IRES translation in multiple myeloma and finds a positive feedback loop between A1 and c-myc. The J007 inhibitor, which disrupts the interaction between A1 and the myc IRES, decreases myc translation and expression, and inhibits tumor growth. These findings highlight the critical importance of A1-dependent myc IRES translation in multiple myeloma.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Rongfang Wei, Xing Cui, Jie Min, Zigen Lin, Yanyan Zhou, Mengjie Guo, Xiaojuan An, Hao Liu, Siegfried Janz, Chunyan Gu, Hongbo Wang, Ye Yang
Summary: This study found that NAT10 is significantly upregulated in multiple myeloma (MM) patients and is closely associated with poor prognosis. Enforced expression of NAT10 promotes MM growth, while its knockdown reverses these effects. Further investigation revealed CEP170 as an important downstream target of NAT10. These findings suggest that NAT10 may serve as a promising therapeutic target in MM.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Oncology
Jing Dong, Zhuping Garacci, Christopher Staffi Buradagunta, Anita D'Souza, Meera Mohan, Ashley Cunningham, Siegfried Janz, Binod Dhakal, Aaron P. Thrift, Parameswaran Hari
Summary: This study assessed the survival differences between non-Hispanic black (NHB) and non-Hispanic white (NHW) patients with multiple myeloma (MM), and found that equitable access to effective treatment modalities is crucial in improving the survival of NHB patients.
BLOOD CANCER JOURNAL
(2022)
Letter
Oncology
Christopher Staffi Buradagunta, Zhuping Garacci, Anita D'Souza, Binod Dhakal, Sumana Devata, Siegfried Janz, Aaron P. Thrift, Parameswaran Hari, Melinda Stolley, Jing Dong
BLOOD CANCER JOURNAL
(2022)
Article
Oncology
Robyn D. Gartrell, Thomas Enzler, Pan S. Kim, Benjamin T. Fullerton, Ladan Fazlollahi, Andrew X. Chen, Hanna E. Minns, Subha Perni, Stuart P. Weisberg, Emanuelle M. Rizk, Samuel Wang, Eun Jeong Oh, Xinzheng Guo, Codruta Chiuzan, Gulam A. Manji, Susan E. Bates, John Chabot, Beth Schrope, Michael Kluger, Jean Emond, Raul Rabadan, Donna Farber, Helen E. Remotti, David P. Horowitz, Yvonne M. Saenger
Summary: Despite complete surgical resection and intense systemic therapies, patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis. Immunotherapies have almost uniformly failed in the treatment of PDAC. This study found that while chemoradiation therapy (CRT) can achieve high T cell densities in PDAC compared to melanoma, the phenotype and spatial organization of T cells may limit the benefit of T cell infiltration in this immunotherapy-resistant tumor.
Article
Biochemistry & Molecular Biology
Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Parameswaran Hari, Siegfried Janz
Summary: FOXM1 plays a crucial role in myeloma metabolism by regulating glycolysis and oxidative phosphorylation pathways. Inhibiting FOXM1 can effectively suppress myeloma growth, offering potential new approaches for therapy and prevention.
Letter
Biophysics
Anita D'Souza, Ruta Brazauskas, Bi Qing Teng, Grant Yun, Hannah Uttley, Jing Dong, Michael B. Dwinell, Marcelo C. Pasquini, Sergio Giralt, Heather Landau, Edward Stadtmauer, Amrita Krishnan, Siegfried Janz
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Samer Al Hadidi, Aniko Szabo, Jean Esselmann, Lindsay Hammons, Munawwar Hussain, Yetunde Ogunsesan, Nishanth Thalambedu, Fatima Khan, Jaskirat Sethi, Abhishek Janardan, Sabarinath Venniyil Radhakrishnan, Sharmilan Thanendrarajan, Carolina Schinke, Binod Dhakal, Siegfried Janz, Saurabh Chhabra, Anita D'Souza, Maurizio Zangari, Frits van Rhee, Meera Mohan
BONE MARROW TRANSPLANTATION
(2023)
Letter
Hematology
Ariel Kleman, Arun Singavi, Lauren Pommert, Angela J. Mathison, Parameswaran Hari, Binod Dhakal, Meera Mohan, Siegfried Janz, Jennifer M. Knight, Mithun Shah, Carolina Schinke, Robert Burns, George Francis Steinhardt, Sridhar Rao, Karen Carlson
Letter
Biophysics
Meera Mohan, Siegfried Janz, Ruta Brazauskas, Michael B. Dwinell, Bi Qing Teng, Grant Yun, Jing Dong, Marcelo C. Pasquini, Sergio Giralt, Heather Landau, Edward Stadtmauer, Amrita Krishnan, Anita D'Souza
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Arathi Mohan, Kent A. Grif, Fulei Wuchu, David B. Zhen, Chandan Kumar-Sinha, Oxana Crysler, David Hsiehchen, Thomas Enzler, Dominique Dippman, Valerie Gunchick, Abhinav Achreja, Olamide Animasahun, Srinadh Choppara, Minal Nenwani, Arul M. Chinnaiyan, Deepak Nagrath, Mark M. Zalupski, Vaibhav Sahai
Summary: This study investigated the effect of the novel inhibitor, Devimistat, in patients with advanced biliary tract cancer. The results showed that Devimistat in combination with Gemcitabine and Cisplatin had a synergistic effect on cells and significantly decreased oxygen consumption rate. In the clinical trial, the combination therapy of Devimistat with Gemcitabine and Cisplatin demonstrated good safety and efficacy.
CLINICAL CANCER RESEARCH
(2023)
Letter
Biophysics
Meera Mohan, Anai Kothari, Nathaniel Verhagen, Aditya Shreenivas, Sabarinath Venniyil Radhakrishnan, Binod Dhakal, Carlos Figueroa-Castro, Saurabh Chhabra, Siegfried Janz, Marcello Pasquini, Mehdi Hamadani, Aniko Szabo, Anita D'Souza
BONE MARROW TRANSPLANTATION
(2023)
Letter
Oncology
Fumou Sun, Yan Cheng, Jun Ying, David Mery, Samer Al Hadidi, Visanu Wanchai, Eric R. Siegel, Hongwei Xu, Dongzheng Gai, Timothy Cody Ashby, Clyde Bailey, Jin-Ran Chen, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Siegfried Janz, Bart Barlogie, Frits Van Rhee, Guido Tricot, John D. Shaughnessy Jr, Fenghuang Zhan
Summary: Researchers used gene expression profiling to stratify the risk of MGUS and developed an optimized signature based on large samples and long-term follow-up. This signature accurately predicted MGUS progression and provided guidance for the management of MGUS patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)