The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis

A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenstrom macroglobulinemia

(2013) G. Yang et al.   BLOOD

MYD88 L265P mutation in Waldenstrom macroglobulinemia

(2013) S. Poulain et al.   BLOOD

Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms

(2013) M. Varettoni et al.   BLOOD

MYD88 L265P in Waldenstrom macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction

(2013) L. Xu et al.   BLOOD

Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstrom's macroglobulinemia

(2013) F. Nguyen-Khac et al.   HAEMATOLOGICA

ETV6 deletion is a common additional abnormality in patients with myelodysplastic syndromes or acute myeloid leukemia and monosomy 7

(2012) M. Wall et al.   HAEMATOLOGICA

Genome-wide Repression of NF-κB Target Genes by Transcription Factor MIBP1 and Its Modulation by O -Linked β- N -Acetylglucosamine ( O -GlcNAc) Transferase

(2012) Yuji Iwashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SWI/SNF-like BAF Complex Is Essential for Early B Cell Development

(2012) J. Choi et al.   JOURNAL OF IMMUNOLOGY

MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia

(2012) Steven P. Treon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

(2012) J. G. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

(2012) Esmé Waanders et al.   PLoS Genetics

Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma

(2011) Manuel Montesinos-Rongen et al.   ACTA NEUROPATHOLOGICA

Target genes of the largest human SWI/SNF complex subunit control cell growth

(2011) Hiroko Inoue et al.   BIOCHEMICAL JOURNAL

The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome

(2011) D. C. Dale et al.   BLOOD

CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia

(2011) H. Makishima et al.   BLOOD

Alteration of BIRC3 and multiple other NF- B pathway genes in splenic marginal zone lymphoma

(2011) D. Rossi et al.   BLOOD

Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses

(2011) K. Karube et al.   BLOOD

The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival

(2011) Antònia Obrador-Hevia et al.   BRITISH JOURNAL OF HAEMATOLOGY

ARID1A, a Factor That Promotes Formation of SWI/SNF-Mediated Chromatin Remodeling, Is a Tumor Suppressor in Gynecologic Cancers

(2011) B. Guan et al.   CANCER RESEARCH

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

(2011) Siân Jones et al.   HUMAN MUTATION

Ebf1orPax5haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

(2011) Lynn M. Heltemes-Harris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Analysis of the coding genome of diffuse large B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE GENETICS

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

(2011) Xingguang Liu et al.   NATURE IMMUNOLOGY

C-MYC rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive anaplastic large cell lymphoma: Identification of a novel fusion gene ALO17/C-MYC

(2010) Hiroshi Moritake et al.   AMERICAN JOURNAL OF HEMATOLOGY

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

(2010) J. C. van Galen et al.   BLOOD

Retinoblastoma Protein-Interacting Zinc Finger 1 (RIZ1) Regulates the Proliferation of Monocytic Leukemia Cells via Activation of p53

(2010) Noman Mohammod Abu Shadat et al.   CANCER INVESTIGATION

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells

(2010) Shelley B Hooks et al.   Molecular Cancer

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

How I treat Waldenstrom macroglobulinemia

(2009) S. P. Treon   BLOOD

A Genetic Screen Identifies Topoisomerase 1 as a Regulator of Senescence

(2009) N. Humbert et al.   CANCER RESEARCH

Identification of Copy Number Abnormalities and Inactivating Mutations in Two Negative Regulators of Nuclear Factor- B Signaling Pathways in Waldenstrom's Macroglobulinemia

(2009) E. Braggio et al.   CANCER RESEARCH

SDF1/CXCL12 (−801GA) polymorphism is a prognostic factor after treatment initiation in Waldenstrom macroglobulinemia

(2009) Stéphanie Poulain et al.   LEUKEMIA RESEARCH

SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia

(2008) H. T. Ngo et al.   BLOOD

Targeting NF- B in Waldenstrom macroglobulinemia

(2008) X. Leleu et al.   BLOOD

CXCR4 dimerization and  -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

(2008) B. Lagane et al.   BLOOD